Gokcumen Lab

Investigating the evolutionary history of genetic variations to explain biological diversity and disease in modern and ancient human populations.

[The Naked Scientists @NakedScientists]

News podcast: @Markusmicrobius (@KingstonUni) on the #hantavirus outbreak; Omer Gokcumen (@UBuffalo) on gene selection in indigenous Andeans; Marcus Michaelangeli (@Griffith_Uni) on salmon on cocaine; and Amy Williams (@UF) on new molecules on Mars

https://t.co/0d7qWr1vW1

[Gokcumen Lab @GokcumenLab]

Our preprint, "Read mismapping from segmental duplications drives spurious trans associations," is out!
We argue that RNA & DNA read mismapping can lead to false signals in QTLs, Hi-C, GWAS, and gene co-expression.
And there is a way to identify them!
https://t.co/fUFZNW0UrU

[Petar Pajic @PetarPajic93]

NEW PAPER in GBE! Saliva is key for digestion, teeth, immunity & oral health, but how did saliva proteins evolve? We show that SCPP genes expressed in salivary glands evolved rapidly via duplications, losses, & regulatory shifts, esp. in primates, with signs of positive selection

[Stefan Ruhl @Ruhl_Lab]

What have 🦷🦷 #TEETH 🦷🦷, 🥛🥛 #MILK 🥛🥛, and💧💧 #SALIVA 💧💧to do with each other? Ask @PetarPajic93 , Luane Landau, and @GokcumenLab ❗️

https://t.co/LvlbsORqkv

[Gokcumen Lab @GokcumenLab]

✨ one of the proudest achievements of my lab. Oldie but Goldie. we delineated the sex- and diet-dependent effects of an ancient deletion (>Neanderthal–human divergence) in the 3rd, highly conserved exon GHR (GHRd3). https://t.co/AMFKyV1ytw
#BioRenderForGrants #ScienceAdvances

[Gokcumen Lab @GokcumenLab]

Great write-up by Technology Networks on our recent work on switch-like gene expression in humans. It is short, clear, and just a 4-min read. If transcriptomic variation interests you, please give it a look!

Paper: https://t.co/ED4KHs2ze7
Write-up: https://t.co/kny0ib7Gsw

[Arts and Sciences | University at Buffalo @UBCAS]

#UBuffalo researchers found nearly 500 human genes that act like light switches—either fully on or off! 💡🧬

Led by Omer Gokcumen, Alber Aqil & Naoki Masuda, the study uncovered genetic patterns linked to fertility, COVID-19, cancer & more.

Read more:
https://t.co/7MedV89CYo

[Gokcumen Lab @GokcumenLab]

Our lab's latest paper, "Switch-like gene expression modulates disease risk," led by our PhD student @AlberAqil, was published in Nature Communications. A collaboration with Naoki Masuda.

Paper: https://t.co/ED4KHs2ze7

Press release: https://t.co/YRrhvbgXTV

[Alber Aqil @AlberAqil]

Our new study, "Switch-like gene expression modulates disease risk," is now out in Nature Communications: https://t.co/HW1DzEfR19
@GokcumenLab @UBBiology @UBCAS @UBuffalo

I am summarizing our key findings in this thread (1/8)