Gong Chen

C-H bonds, peptides, carbohydrates

[Gong Chen @GongChenLab]

We turned a triazole ring into a molecular mousetrap—snapping up amino groups for bioconjugation! 🧠💥
Super reactive, highly selective, and thiol-tolerant.
Great teamwork with Huadong Xu (Changzhou University)!

[J. Am. Chem. Soc. @J_A_C_S]

Snap-Trapping Strategy for Amine-Specific Bioconjugation with Pyridotriazole Carbaldehydes | Journal of the American Chemical Society https://t.co/ZA9sYhmLv8

[Gong Chen @GongChenLab]

We’ve been dreaming of this type of conjugation chemistry for years—and finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CS₂. Minimalist chemistry is the new gold. ✨

[Angewandte Chemie @angew_chem]

@gongchenlab have been hunting for ways to crosslink two different amines for conjugation: turns out that just a drop of CS₂ in air delivers great results! Read on in their Research Article: • https://t.co/u8OqVKjDCC

[Gong Chen @GongChenLab]

A huge thank you to our amazing guest editors, Masayuki Inoue, Lara Malins @Malins_lab, and Hans Renata @hanzyduzit, for organizing this OL special issue on radical-mediated reactions! Special thanks to Steve Ritter and Matt Saucier for your invaluable support.

[J Org Chem/Org Lett @JOC_OL]

Special Issue alert! 🚨 This one is truly •radical•
https://t.co/1brknWrgqF

This VSI highlights the state of the art in radical reaction development and the strategic incorporation of radical reactions in the construction and modification of important molecules.

[Gong Chen @GongChenLab]

Interested in sulfonium ylide chemistry? Don’t miss Biao Xiong's latest Organic Letters paper @JOC_OL on a sleek Cu-catalyzed [3+2] route to 5-CF3-pyrroles, starting from CF3-imidoyl sulfonium ylides and terminal alkynes.

[ChemistryViews @ChemistryViews]

Copper-Mediated Cyclization Gives 5-Trifluoromethylpyrroles:
Practical approach uses CF3-imidoyl sulfoxonium ylides and terminal alkynes
https://t.co/JnuRfcKsNt

[Gong Chen @GongChenLab]

HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.

[Angewandte Chemie @angew_chem]

Peptide Stapling by Crosslinking Two Amines with alpha-Ketoaldehydes through Diverse Modified Glyoxal-Lysine Dimer Linkers (Gong Chen and co-workers) @NKU1919 https://t.co/rTEzAWEw9F

[Gong Chen @GongChenLab]

We are grateful for the swift publication of this work in @NatureSynthesis and the outstanding editorial assistance received!

[Gong Chen @GongChenLab]

N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.

[Gong Chen @GongChenLab]

N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.

[Nature Synthesis @NatureSynthesis]

Now online:

Article by @MJKoh87 @GongChenLab and co-workers @NKU1919 @ChemNUS

N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles

https://t.co/93Xl4Pwm1P ($)

[Gong Chen @GongChenLab]

@GoisLab Thanks, Pedro!

[Gong Chen @GongChenLab]

Two simple reagents, HCHO and hexafluoroisopropanol (HFIP), unleash new chemical magic! HCHO effectively “sucks” the alpha C-H bond from common alkyl amines in HFIP solvent, enabling hydride liberation without metals or light. It works for complex systems, too.

[Top Science @isciverse]

Formaldehyde-Mediated Hydride Liberation of Alkylamines for Intermolecular Reactions in Hexafluoroisopropanol

@J_A_C_S #Chemistry #Chemed #Science

https://t.co/EIjQf9WmvF

[Gong Chen @GongChenLab]

@MoranLabChem Thanks!! More magic with HFIP is coming soon :)

[Gong Chen @GongChenLab]

@NitscheLab thank you for the very kind support of our meeting, look forward to seeing you again in Brisbane in a couple of months🤝

[Gong Chen @GongChenLab]

@NgaiLab congratulations 🎊

[Gong Chen @GongChenLab]

I am deeply humbled and honored to be part of the editor team of Organic Letters. I very much look forward to serving the journal and our organic community☺️

[J Org Chem/Org Lett @JOC_OL]

We are thrilled to announce that Prof. Gong Chen of Nankai University will be joining #OrgLett as an Associate Editor on December 1. Known for his work on metal-catalyzed C-H functionalization and on peptides and oligosaccharides, Gong may soon be handling your manuscript!

[Gong Chen @GongChenLab]

@alexanderln91 @libo019796991 Thanks Alexander!

[Gong Chen @GongChenLab]

@BookerMan_PSU Thanks Squire! Sure, I would love to!

[Gong Chen @GongChenLab]

Our lucky streak continued! Formaldehyde can glue amine and guanidine together like a charm :) Thank Xiaosong Xue at Nankai and SIOC for the computational collaboration! https://t.co/T7mGFvZMFN

[Gong Chen @GongChenLab]

@junwu54104779 Thanks so much!

[Gong Chen @GongChenLab]

@TomNGrossmann @J_A_C_S Thanks a lot Tom!

[Gong Chen @GongChenLab]

@samuccen Much appreciated 😊

[Gong Chen @GongChenLab]

@MonikaRaj_lab Congratulations Monika!