Grayson Tilstra

PhD Candidate at @UofT @bme_uoft | Chemist 🧪 | Developing lipid nanoparticles for RNA delivery @ofklab | Co-founder @AzaneTx

[Biomedical Engineering @ University of Toronto @bme_uoft]

Researchers at the UofT shed new light on a crucial challenge in the field of nucleic acid drug delivery: how to make lipid nanoparticles (LNPs) break down more quickly in the body: https://t.co/IHGSA9nlQN

[Grayson Tilstra @GraysonTilstra]

And if you want the quick dopamine rush from the results, check out this thread from my fantastic collaborator @juliencsenecal!

[Grayson Tilstra @GraysonTilstra]

Excited to share our recent work, out now as a preprint! LNP-based vaccines cause a lot of inflammation. We describe a strategy to dampen this inflammation through ionizable lipid chemistry while maintaining vaccine efficacy. https://t.co/vyt4r2ylpU

[Grayson Tilstra @GraysonTilstra]

@Trav_Douglas11 Typical

[Janice Pang @JanicePang_]

Thank you @bme_uoft for the feature of our journey with @Varsity_Blues Women's Curling and PhD research!

It was only coming to @UofT that I was able to realize my dream of pursuing both my athletics and academic goals. Grateful for the lessons of perseverance and hardwork.

[Grayson Tilstra @GraysonTilstra]

Check out the bio of my fellow @OFKLab member and chemist @mia_oproescu!🧪

[Biomedical Engineering @ University of Toronto @bme_uoft]

Meet Ana-Maria, a PhD student in Dr. Omar Khan’s lab. Ana-Maria’s journey seamlessly weaves together her love for art, her dedication to advancing scientific frontiers, and her commitment to breaking barriers in the medical field: https://t.co/RCXhLXk40Q

[shana alexander @shanalexander4]

Excited to share our manuscript on @biorxivpreprint where we adapted origamiFISH (DNA origami detection in cells and tissues via fluorescent in situ hybridization, FISH) from confocal imaging to flow cytometry, origamiFISH-Flow! https://t.co/LA3hOnqs9I

[Grayson Tilstra @GraysonTilstra]

First day of the @mrnaconference with @juliencsenecal! It was a long trip to Berlin but we're excited to be representing the @OFKLab with two posters this year.

[Wendy Xueyi Wang @Awedness]

Excited to share our new method for label-free imaging of DNA origami nanodevices in @NatureNano. We hope origamiFISH will be a resource to the community, and help in future expansions of the DNA nanotech toolbox. @leochou0814 @Trav_Douglas11 @LabMegatron https://t.co/Vu2lfs47Yw

[Grayson Tilstra @GraysonTilstra]

Congratulations to Alanna and all of the collaborators on this paper! Exciting to finally see it out in the world.

[OFK Lab @OFKLab]

What happens when you merge ionizable lipid design with supramolecular chemistry? Great RNA nanoparticles with thermostability! Read about our supramolecular ionizable lipid in the latest paper from Alanna M. Manning and the #OFKLabBlueCoats https://t.co/UrRsTeOGTY @AdvSciNews

[Grayson Tilstra @GraysonTilstra]

@DavidRWilson @leochou0814 I was also surprised that they didn't compare their results to the Li et al. paper. This new study also uses a weird cationic LNP formulation (DOTAP, no phospholipid, 60% monoolein) so I would be interested to see the encapsulation results with a benchmark formulation.

[Grayson Tilstra @GraysonTilstra]

@BowenLi_Lab The use of an Ugi reaction for a combinatorial screen is quite clever! Excited to see where you go with these ideas.

[Grayson Tilstra @GraysonTilstra]

It's everyone's favourite reporter protein, Firefly Luciferase! 💡

Done with the new update to #molecularnodes from @bradyajohnston. Having direct access to protein secondary structure in Blender makes for striking renders.

#sciart #b3d #Blender3D

[Grayson Tilstra @GraysonTilstra]

Congratulations to Myoxa from @GartonLab! Proud of our fellow @bme_uoft entrepreneurs in their first pitch🎉.

[Medicine by Design @MbD_CCRM]

Congrats to our Building a Biotech Venture Pitch Competition winners on receiving 25k and 10k in research funding!
1st place - Myoxa Therapeutics (@GartonLab)
2nd place - Specific Dx (@Joseph_Ferenbok lab)

Congrats to all 6 teams on a successful pitch👏🏽

[Grayson Tilstra @GraysonTilstra]

I made this short idle animation of a lipid nanoparticle encapsulating mRNA! I recently got into using Blender (with lots of help from @bradyajohnston @CgFigures for tutorials and plugins) and its been fun. #molecularnodes is not just for proteins 😁. #b3d #sciart

[Grayson Tilstra @GraysonTilstra]

@juliencsenecal @UofTEPIC @OFKLab Awesome, congrats! 🎉

[Grayson Tilstra @GraysonTilstra]

@juliencsenecal and I getting ready to present in the NanoBio Journal Club.

[Wilson Poon @wilsonpoon]

🚨#Nano colleagues! Here's our April NanoBio Journal Club meeting!🚨

🗓️ Wed Apr 26, 4:30pm US Eastern
🗣️ @GraysonTilstra & @juliencsenecal (@bme_uoft, University of Toronto)
📑 https://t.co/9u2RHQK09k
🛰️ https://t.co/zgKh7iO10I

Open to everyone, please register via link above!

[Grayson Tilstra @GraysonTilstra]

@BowenLi_Lab @kochinstitute @MIT @NatureBiotech @UMassChan Congrats Bowen!