We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. https://t.co/8rPe1G87CZ🧵👇 🔗
We are looking for a highly motivated and curious PhD candidate with a strong interest in biology, computational methods, and theory 🧫 📊 🤓
Join us to work on ecological and evolutionary processes in bacteria and beyond!
Apply by March 26th! 🏃♀️ 🏃♂️
https://t.co/VguvjbJH4m
1/ I'm a bioinformatian who uses Claude (and code) every day. Most people use it like a search engine. Anthropic quietly published a page that shows you what you're actually missing.
Our paper on variational synthesis is out now in Nature Biotechnology. Manufacturing-aware generative models — AI architectures that know how to physically build their own designs — enabling synthesis of DNA encoding ~10^16 AI-designed proteins at a cost that would be roughly a quadrillion dollars using conventional methods.
1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.
Today marks a meaningful milestone -- I am starting as a lab investigator @CompOncMSK and thoracic oncologist @MSK_DeptOfMed, focused on improving treatment through a deep understanding of cancer evolution. I'll soon be looking for fellow travelers on this mission. Stay tuned!
Excited that this is out in @PNASNews !
https://t.co/G7CuvCXAY7
In a sentence, we show that different mutational processes can have different long-term impacts on eco-evolutionary systems. 1/n
Part 2 of our combined efforts with @SohrabShah and @VStrongMD to understand immune evasion in gastric cancer describes the work in this preprint, led by @GreedyApple and Emily Stroobant in a brilliant collaboration: https://t.co/JH2nTgc80T
Congratulations to my Cambridge colleague Shankar Balasubramanian, his colleagues David Klenerman and Pascal Mayer on the award of a Canada Gairdner International award for their invention of short read massively parallel DNA sequencing. https://t.co/lUH5C2sawU