Lea Haarup Gregersen

Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC, @BIMSB_MDC and @TheCrick

[Lea Haarup Gregersen @GregersenLab]

❗️5 days left to apply for a PhD position in our group👇

[Lea Haarup Gregersen @GregersenLab]

🧬 Passionate about transcription?

🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen

Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩‍🔬👨‍🔬 https://t.co/1IHWCoqOJa

Apply by Apr 10, 2026
https://t.co/SLfqWL8Zq7

[Lea Haarup Gregersen @GregersenLab]

🧬 Passionate about transcription?

🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen

Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩‍🔬👨‍🔬 https://t.co/1IHWCoqOJa

Apply by Apr 10, 2026
https://t.co/SLfqWL8Zq7

[Lea Haarup Gregersen @GregersenLab]

Thank you to collaborators Gertrud Hjortø, Tom Miller, @JZylicz and support from colleagues at @UCPH_health

[Lea Haarup Gregersen @GregersenLab]

What is the function of the RNAPII-interacting SCAF proteins?

In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬🧠

Loss of SCAF1 → shorter mRNA transcripts

https://t.co/0BsnwNelAU

[Lea Haarup Gregersen @GregersenLab]

Thank you to everyone involved and support from colleagues at Center for Gene Expression (CGEN), @UCPH_health!

[Lea Haarup Gregersen @GregersenLab]

What happens to transcription upon oxidative DNA damage? 🧬💥

RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦

👀 How? Find out in our new preprint👇
https://t.co/YBTELBmiho

[Lea Haarup Gregersen @GregersenLab]

Key takeaways:
🔍Oxidative damage causes shutdown of transcription, without RNAPII degradation
🔍Stalled RNAPII resumes transcription from within the gene body
🔍PARylation controls early elongation restart
🔍BER and SSBR repair enable RNAPII recovery in the gene body

[Lea Haarup Gregersen @GregersenLab]

This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response:

• Promoter regions: PARylation governs early RNAPII release
• Gene body: DNA damage and repair drive RNAPII stalling

[Lea Haarup Gregersen @GregersenLab]

Huge thanks to our amazing team and members with CGEN for fruitful discussions 🙌

[Lea Haarup Gregersen @GregersenLab]

Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure RNAPII elongation rates across 3,000+ genes 🧬https://t.co/wMFxLSARli
Fantastic work led by @liu_haiyue
More details below! 👇
#Genomics #Transcription #RNAPII #ElongationRates

[Lea Haarup Gregersen @GregersenLab]

What did we find? ✅ Elongation rates vary between genes ✅…and within genes ✅ Histone marks & elongation factors correlate with rate subclasses

[Lea Haarup Gregersen @GregersenLab]

The computational pipeline independently applies to existing DRB/TTchem-seq datasets - so you can improve the number of genes with single gene elongation rates from existing data, simply by using the new computational pipeline

[Lea Haarup Gregersen @GregersenLab]

Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework 📈 leading to a ~7 fold increased individual gene elongation rates measurements!

[Lea Haarup Gregersen @GregersenLab]

❗️One more week to apply for a PhD position in our group! Come join our team of transcription enthusiasts in Copenhagen👩‍🔬👨‍🔬

[Lea Haarup Gregersen @GregersenLab]

We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs
@uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (https://t.co/1IHWCoqOJa) Great city and amazing research environment. Deadline March 6 https://t.co/AzMgQXUwLI

[Lea Haarup Gregersen @GregersenLab]

Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @uni_copenhagen. Want to join our team to work on transcriptional regulation? More information at: https://t.co/bY0PpSkXhJ Deadline March 18. Apply here: https://t.co/8CA9EuJc4p

[Lea Haarup Gregersen @GregersenLab]

We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs
@uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (https://t.co/1IHWCoqOJa) Great city and amazing research environment. Deadline March 6 https://t.co/AzMgQXUwLI

[Thomas Miller @TCR_Miller]

Looking for a #postdoc or #PhD in eukaryotic #DNA replication and #CryoEM? We are recruiting! The positions are fully-funded by the @novonordiskfond and come with access to cutting-edge facilities and fantastic colleagues in #Copenhagen. See links below for more information.

[Lea Haarup Gregersen @GregersenLab]

Happy to be back among old colleagues and friends in Berlin mixed in with amazing science 🧫

[MDC-BIMSB @BIMSB_MDC]

Proud to showcase a selection of our alumni during session 2 of the Berlin Summer Meeting 2023: Pinar Önal, @baris_tursun @TursunLab, Elena Torlai Triglia, Lea Haarup Gregersen @GregersenLab & @M_Munschauer
#mdcBIMSB2023
@MDC_Berlin

[Lea Haarup Gregersen @GregersenLab]

Great opportunity for a postdoc in Copenhagen 👇👇

[Kathleen Stewart-Morgan @stewmorganlab]

We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply.

Deadline: 17 September
Apply here: https://t.co/nygCrG02s5

Please retweet!

[Lea Haarup Gregersen @GregersenLab]

Great opportunity for a PhD position 👇👇

[Rune Busk Damgaard @rbdamgaard]

📢 PhD scholarship in Copenhagen 🇩🇰

Do you want to...
🧬 study how ubiquitination regulates cellular metabolism in disease states?
👩‍🔬 join an international and ambitious team?

✅Then apply here before 11 Sep to join my team: https://t.co/71snneabST