Rune Busk Damgaard

Associate Professor, Section for Medical Biotechnology, Technical University of Denmark. Studies ubiquitin signalling in inflammation, metabolism, and disease.

[Rune Busk Damgaard @rbdamgaard]

More evidence that LUBAC has functions beyond immune signalling. Our recent study shows that LUBAC and OTULIN regulate metabolic signalling: specifically they govern AMPK signalling to control metabolic adaption, autophagy, and cell death during energetic stress. This suggests that the metabolic symptoms observed in patients with LUBAC deficiency and ORAS, including glycogen storage disease, lipodystrophy, and liver disease, may be caused directly my metabolic dysregulation rather than being secondary to the systemic inflammation.

https://t.co/r3BLoOR2Nu

[Pontus Rendahl @pontus_rendahl]

Good points

https://t.co/oAQYT8Z638

[Pontus Rendahl @pontus_rendahl]

AI will be the end of universities! MOOCs will be the end of universities! YouTube will be the end! Libraries! The printing press!

And each time life continues almost as before. Universities provide peer interaction, evaluation, coordination and commitment. That’s the value.

[Fengjun(FJ) Zhang, PhD @fengjun_zhang]

@arjunrajlab I am trying to build a framework that can use all the these published atlases
Despite of so many cell atlases being published, the reusablility is really poor
Tons of animals and money just being flooded away without reaching a proper researcher 😢

[Arjun Raj @arjunrajlab]

Can someone start a journal called “Cell Atlases” so that the rest of the journals can go back to publishing interesting things?

[Rune Busk Damgaard @rbdamgaard]

@omDSB Tak for svar 👍

[Rune Busk Damgaard @rbdamgaard]

Hej @omDSB. Hvorfor kan man ikke købe returbilletter ud jeres nye “købsflow”? Hvorfor skal jeg købe to individuelle billetter og betale af to omgange? Jeg kan heller ikke vælge sæde? Men blot at jeg gerne vil have et…?Det er en seriøs downgrade af jeres billetbutik og service.

[Christoffer Zieler @ZielerChris]

Medmindre opgaven er at bruge AI, giver det ingen mening at bede gymnasieelever skrive hjemmeopgaver. Utroligt, det ikke er lavet om for flere år siden. Sæt dem til at skrive opgaver i hånden henne på gym uden adgang til AI og bedøm dét.

[Lasse Vrist @lassevrist]

Nå, de unge snyder i gymnasiet. Tænk en gang! Men AI fylder så meget, at lærerne ikke stoler på det, de læser. Hvorfor så overhovedet bruge tid på at lære fra sig? Og endnu vigtigere, hvad er det eleverne bruger tiden på, når de AI-generer deres opgaver. Artikel om det (m. link):

[Sholto David @addictedtoigno1]

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact ThermoFisher has systematically manipulated antibody validation data. Short Thread... 🧵

[Michael Lin, MD PhD 🧬 @michaelzlin]

It seems quite the fad these days, even among scientists, to assert how well AI can perform "science". Or maybe that's just what X amplifies.

In any case these obligatory genuflections to AI just accept the definition of science as being mundane literature reading, run-of-the-mill associative hypothesis testing, and brute-force data gathering and model fitting.

They don't differentiate competent but iterative work from the truly out of the ordinary and creative. Both are important, but only one is emulated by AI.

[Lior Pachter @lpachter]

I sure hope AI gets a high paying job because it's going to need $12,850 for each of the thousands of papers a month it's going to be publishing in Nature.

Also a concern is whether it will have enough left over every month to pay the mortgage for the data center where it lives.

[Sholto David @addictedtoigno1]

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.

[Neil Renic @NC_Renic]

Still think we’re understating the impact of AI on university degrees. A growing numbers of students don’t just lack the inclination to read but the *capacity*. Literally unable to read and absorb difficult sentences for an extended period. Same goes for writing.

[Matthew Berman @MatthewBerman]

i'd watch a whole season of this

[Jonathan Birch @birchlse]

UK universities are miraculous. A case in point is the University of Sheffield, which has a total endowment of £59m (about 21x Princeton's per-student endowment) and 6 Nobel prizes. We're losing one of the most cost-effective research juggernauts on Earth.

[Connor Ewing @ConnorMEwing]

A modest proposal: If you submit a manuscript with a made-up citation—not a bungled or misspelled reference—you receive a 5-year ban on having your work reviewed at that journal.

[Salim S. Hayek, MD @salimhayek]

One of my NIH grant reviews came back last year with comments clearly LLM-generated. The PMIDs cited against the proposal were hallucinated. The papers did not exist. The score still counted toward the funding decision.

[Jonas Herby @JonasHerby]

"Mens Alternativets forperson i København, Birgitte Kehler Holst, var på ferie i Chile i december og januar. ."

Og det var Chile. Svømmere hun mon derned, siden hun tillader sig at være så hellig på de ældres bekostning?

https://t.co/IJHzwKcqcs

[Dr. María D. Mayán @MariaDMayan]

ERC is at a turning point, and not in the right direction.

Excellent science needs support, not barriers @ERC_Research

Read & sign 👇

https://t.co/Ho8bKVVfXX

[Neil Stone @DrNeilStone]

Without Xrays there are no broken bones