Karol Grela

Chemistry. Catalysis. Fun.
#TakDlaCPK #TakDlaRozwoju (Private opinions)

[Visegrád 24 @visegrad24]

Poland and Lithuania celebrate the 3rd of May 1791 Constitution, the most advanced document of state law at the time.

Even though the Commonwealth was defeated and partitioned by imperial powers, the principles of equality of th Constitution are still valid today.

🇵🇱🇱🇹

[Karol Grela @GrelaGroup]

https://t.co/04OKX6ivam

[Karol Grela @GrelaGroup]

Hard to disagree… ☺

[Filip Styczyński @FilipStyczynski]

Today is the 3 May Constitution Day in Poland.

It was the first constitution in Europe.

[Karol Grela @GrelaGroup]

Koniecznie do przeczytania. https://t.co/HM5LhkdG8M

[Karol Grela @GrelaGroup]

We are delighted to see that this concept is being used and cited by others. ♥

[Karol Grela @GrelaGroup]

We believe that the beauty of olefin metathesis lies in its remarkable flexibility and versatility.

In 2018 we explored the chain clipping/ring contraction with unprotected dienes. To probe the above strategy, we chose to start with precursors of macrocyclic musks. To shift alkenes, we opted to use Grotjahn’s “alkene zipper” catalyst (Ru(Cp), a purchasable complex that has been shown to promote a that has been shown to promote E-selective isomerization.

https://t.co/DsFGhk1pbd

[Karol Grela @GrelaGroup]

cf. Chemistry – A European Journal, 2018, 24, 10403-10408.
Sequential Alkene Isomerization and Ring-Closing Metathesis in Production of Macrocyclic Musks from Biomass
Adrian Sytniczuk, Dr. Gwénaël Forcher, Prof. Douglas B. Grotjahn, Prof. Karol Grela
(First published: 21 June 2018)

https://t.co/rhi1PScClg

[Hoveyda Lab @HoveydaLab]

We are very excited to present our recent work, which just appeared in @ScienceMagazine (Ahead of Print) on a deconstructive synthesis strategy for efficient, programmable and stereocontrolled preparation of precisely modified macrocyclic skeletal analogs.
https://t.co/hMmPvtwG0x

[Polska Akademia Nauk @PAN_akademia]

Święta to chwila zatrzymania, oddechu i nowej energii.

Radosnych Świąt Wielkanocnych życzy Polska Akademia Nauk.

[Karol Grela @GrelaGroup]

Analytical Challenges in Detecting New Psychoactive Substances in Anti‐Doping: A Proof‐of‐Concept Involving Pentedrone Metabolite - Kwiatkowska - 2026 - Drug Testing and Analysis - Wiley Online Library https://t.co/snCnD6kxFK

[Shuai Chen 陈帅 @chenshu72058810]

The long-standing challenge of converting alkenes directly to alkynes—classically a harsh two-step halogenation/elimination—is solved by Ning Jiao & team! 🔗https://t.co/vOhwavTfUC #OrganicChemistry #OrganicSynthesis #Alkyne #Nature #Chemistry

[Karol Grela @GrelaGroup]

Sytniczuk A, Peta B, Grela K. “Is cyclic (alkyl)(amino)carbene a new N-heterocyclic carbene? A ligand story in ruthenium-catalyzed olefin metathesis”, Trends in Chemistry, 2026; 8, 189-202
[DOI: https://t.co/fYt4q9c6e7 ]

→ Direct link (free access before April 22, 2026):
https://t.co/lL8a8h1Rhy

[Karol Grela @GrelaGroup]

Is cyclic (alkyl)(amino)carbene a new N-heterocyclic carbene?

“The development pathway of any catalyst family can be—through a somewhat stretched comparison—likened to the evolution of a family of aircraft. When analyzing the silhouettes and designs of major fighter aircraft from 1938 to 1942, significant similarities are readily apparent. All of them—whether the Spitfire with its mathematically elegant elliptical wings or the more angular designs of Professor Messerschmitt—were, with only a few exceptions, low-wing monoplanes with retractable landing gear and inline engines driving a propeller…”

Read more about our view on the development of NHC and CAAC ruthenium olefin metathesis catalysts in our Opinion in Trends in Chemistry (link in a comment). #reviews #chemistry

(Airplanes artwork © @GlobalPower123 FB profile)

[Olefin_Metathesis @Olef_Metathesis]

A Convenient, Safe, and Atom-Economical Route to a Large Portfolio of Grubbs-Type Catalysts for Olefin Metathesis via Four-Coordinate Ruthenium Alkylidynes (@angew_chem) https://t.co/mY8myP5uz5

[Karol Grela @GrelaGroup]

Sometimes one picture is worth a thousand words.

First artwork made by @RafalKusy for “Renaissance in Alkyne Semihydrogenation: Mechanism, Selectivity, Functional Group Tolerance, and Applications in Organic Synthesis” (https://t.co/92YY4dIYMM)

Second one “Imperial Lifecycles: Arcs of Reign and Demise Among Roman Emperors” borrowed from: https://t.co/pjWXn1cbzC

[24th International Conference on Organic Synthesis @24ICOS]

📢 Good news 📢

⏳ The deadline for submitting abstracts for oral presentations has been extended to March 31.

Don’t miss your chance!

🔗https://t.co/3wA3HgDZuH

[Karol Grela @GrelaGroup]

🛩️Our Opinion piece “Is cyclic (alkyl)(amino)carbene a new N-heterocyclic carbene? A ligand story in ruthenium-catalyzed olefin metathesis” is now in press in Trends in Chemistry! @TrendsChemistry
Congratulations to all co-authors!
We raise some questions and look forward to your comments. 🤗 https://t.co/lL8a8h1Rhy

[Karol Grela @GrelaGroup]

@ForumAkad @MarcinKulasek @MNiSW_GOV__PL Panie Ministrze, miło nam, ale sprzęt badawczy nam się sypie, nie ma pieniędzy na części zamienne, na serwis, na techników.

[Karol Grela @GrelaGroup]

Dedicated & smart candidates – we want YOU! ♥

New positions in @GrelaGroup's NCN OPUS Grant.

Pushing olefin metathesis frontiers from https://t.co/LTW3J97KKG & https://t.co/EZyO4q9iiD state-of-the-art into new architectures & applications.

Apply now: https://t.co/53esVy1C44