Gustafson Group @ Stony Brook

Asymmetric Synthesis and Chemical Biology

[Gustafson Group @ Stony Brook @GustafsonLab]

The S-Atropisomer* had no KIT activity, but displayed intriguing selectivity towards LYN kinase, an emerging target for the treatment of cancer, autoimmune diseases and inflammatory conditions, that currently lacks highly selective inhibitors.

[Gustafson Group @ Stony Brook @GustafsonLab]

Another day another preprint on ChemRxiv!
“Leveraging Atropisomerism to Obtain a Mutant-Selective c-KIT Inhibitor in Gastrointestinal Stromal Tumors”
A story of privileged heterocycles, atropisomerism and kinase selectivity.
https://t.co/tlSyYPLCQT

[Gustafson Group @ Stony Brook @GustafsonLab]

The R-atropisomer* maintained potency against cellular models of GIST (IC50 < 10 nM) while displaying improved target selectivity, including towards key oncogenic c-KIT mutants. *Cahn-Ingold-Prelog priorities cause the analogs to have opposite stereochemical descriptors.*

[Gustafson Group @ Stony Brook @GustafsonLab]

This led us to introduce a peri Fluoro group as a H-bonding handle to ‘lock’ that axis into the trans conformation. This seemingly simple modification led to a dramatic increase in HER selectivity, particularly towards HER4, a kinase with emerging implications in ovarian cancer.

[Gustafson Group @ Stony Brook @GustafsonLab]

Excited to share our new ChemRxiv preprint:
“Leveraging Conformational Control of Neratinib’s C–N Axes to Enhance HER4 Selectivity in Ovarian Cancer”
congrats to the tam @StonyBrookChem and @SDSUChemBiochem
Read here: https://t.co/0gyoBcOgUc

[Gustafson Group @ Stony Brook @GustafsonLab]

The ‘conformational mapping’ of diarylamine crystal structures suggested that the pan-HER kinase inhibitor neratinib adopts two planar conformations around a C–N axes (similar to cis and trans alkenes). HER family kinases generally preferred the ‘trans’ conformation

[Gustafson Group @ Stony Brook @GustafsonLab]

The final version of this manuscript is up at @ACSCatalysis
https://t.co/RGUESD8DI9

[Gustafson Group @ Stony Brook @GustafsonLab]

I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. https://t.co/0QbvvTBSmn...

[Jeff Lipshultz @jeflip]

Our department (@StonyBrookChem) is looking for a PRODiG+ fellow – the appointment is two years, followed by conversion to a tenure-track assistant professor at the conclusion of the fellowship. A unique opportunity!
https://t.co/eQwXVBmTdc

[Gustafson Group @ Stony Brook @GustafsonLab]

Reposting. One more week until the deadline!

[Gustafson Group @ Stony Brook @GustafsonLab]

The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! https://t.co/rdDzReWL0s

[NaOH Bartfield, PhD 🧪 @NaOHBartfield]

Doctor Gavin Rustin we salute you

[Gustafson Group @ Stony Brook @GustafsonLab]

Check out our latests work in collaboration with @Taylorlab_Chem ! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected the rapid trifluoromethylation of diverse aromatics, including several APIs.
https://t.co/lS1020lIrA

[Gustafson Group @ Stony Brook @GustafsonLab]

The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! https://t.co/rdDzReWL0s

[Organic Syntheses @OrgSynth]

Professor Jeff Gustafson (Stony Brook University, @GustafsonLab) (https://t.co/SN8258wn9u) presented the Organic Syntheses Lecture at Notre Dame on September 24th, 2025.

[Jeff Lipshultz @jeflip]

Come join us at @StonyBrookChem! We are looking for an Assoc/Full Prof in Materials or Polymer Chemistry, supported by the SUNY Empire Innovation Program. Deadline Oct 16. Reach out if you have any questions! https://t.co/DdEFvGdmUg #facultychemjobs

[Gustafson Group @ Stony Brook @GustafsonLab]

Just got back from another excellent Heterocyclic Compounds GRC and am excited to have been elected Vice-Chair. I look forward to putting together an exciting program in 2027! Happy to hear any cool ideas for session topics.

[Byron Purse @ByronPurse]

Call for Abstracts: An oral symposium on Synthetically Modified Nucleosides and Nucleic Acids on October 26, 2025 at the @CaliforniaACS Western Regional Meeting in San Jose! Apply, share widely, and DM or email me with questions. https://t.co/8wWLXFooVl

[Jeff Lipshultz @jeflip]

This week marked the Third SBU-BNL Photochemistry Supergroup, with a great poster session and 10 speakers from @StonyBrookChem and MSCE, @BrookhavenLab, @QC_News, @HofstraU, and @AdelphiU! Thanks to @SBUResearch for supporting this event!

[Gustafson Group @ Stony Brook @GustafsonLab]

here is the correct link: https://t.co/qmTyD25h5J

[Gustafson Group @ Stony Brook @GustafsonLab]

I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. https://t.co/0QbvvTBSmn...

[Gustafson Group @ Stony Brook @GustafsonLab]

This work was led by Ryan zanolini and Mariam Basilaia. It also involved a fun collaboration with @YuezhiMao that shed light on how stereochemistry was induced (spoiler alert: Dynamic Kinetic Resolution of the indole).