Guy Oldrieve

Postdoctoral researcher at The University of Edinburgh

[Keith Matthews @KeithRMatthews]

New paper to assist all looking at VSG expression diversity-another excellent effort from @GuyOldrieve

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression https://t.co/U6FSy3IZQI

[Biological Sciences | University of Edinburgh @SBSatEd]

Great to see this new work published from @GuyOldrieve and @KeithRMatthews @edin_eid showing how the parasites that cause sleeping sickness can spread beyond their native Africa as a result of mutations to key genes

https://t.co/21pKoh67dQ

[Keith Matthews @KeithRMatthews]

Mechanisms of life cycle simplification in African trypanosomes https://t.co/CQliraspup

A huge effort from @GuyOldrieve exploring how monomorphic trypanosomes can escape dependence on tsetse for their transmission and what it tells us about mechanisms of stumpy formation.

[Edinburgh Infectious Diseases @edin_EID]

Delighted to hear from both our Ker Memoral Prize winners @GuyOldrieve and Andy Gibson. Really well deserved winners!

Congrats to both and read more about their work here: https://t.co/tS6XJD2oq2

#EIDSymp24

[McCulloch Lab Group @McCulloch_Group]

Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6

https://t.co/3EpybzkLkj

[Keith Matthews @KeithRMatthews]

Another one through the gate. Congratulations Guy on your graduation! ⁦@SBSatEd⁩ ⁦@wt_hpgh⁩

[Keith Matthews @KeithRMatthews]

Can you store your trypanosome scRNA samples by freezing and still preserve their transcriptome? Yes you can! And you can map their cell cycle while you're at it.
https://t.co/3sSOR0LYam
@emmabriggs6 👏👏
@SBSatEd

[Symposium on African Livestock Trypanosomiasis, Tz @SALTTz_2023]

And that leads us nicely to a group photo (the first of many, we're sure) of the #SALTTz attendees in the glorious Arusha sunshine!

[Edinburgh Infectious Diseases @edin_EID]

Really good to have all the ⁦@wt_hpgh⁩ PhD students together at the programme retreat in Crieff over the last couple of days😊

[Guy Oldrieve @GuyOldrieve]

@sturalph @BiologyOpen @KeithRMatthews Agreed! We made sure to caveat our suggestion by highlighting alternative causes of AT bias. We like the codonmuse suggestion re nutrient availability, especially as they highlight the same pattern in highly divergent groups (such tryps and mollicutes)

[Guy Oldrieve @GuyOldrieve]

Our paper is out in @BiologyOpen. Comparing closely related non-pathogenic trypanosomes, we highlight differential investment in cell-surface genes and predict this is associated with the life histories of their hosts and vectors https://t.co/8La9JWIZ7b @KeithRMatthews

[Guy Oldrieve @GuyOldrieve]

@sturalph @BiologyOpen @KeithRMatthews and propose that the reduction in the selection cost of T. theileri and T. melophagium may be related to their non-pathogenic nature

[Guy Oldrieve @GuyOldrieve]

@sturalph @BiologyOpen @KeithRMatthews Phytomonas has limited access to nitrogen as it infects nitrogen deficient plants and has been highlighted as an example where diet can cause selection to reduce the species genome nucleotide cost, through a reduction in GC content

[Guy Oldrieve @GuyOldrieve]

@sturalph @BiologyOpen @KeithRMatthews Here are links to their GitHub (https://t.co/8P2y92FfZY) and their papers https://t.co/V0qShkru3n & https://t.co/AVRAHT5FrR

[Guy Oldrieve @GuyOldrieve]

@sturalph @BiologyOpen @KeithRMatthews CodonMuSe defines biosynthetic costs as “the number and type of atoms contained within the codon or the number of high-energy phosphate bonds required for their assembly”

[The Company of Biologists @Co_Biologists]

Thanks to Guy Oldrieve @GuyOldrieve for sharing his experience of fee-free #openaccess publishing in @BiologyOpen via our #ReadAndPublish agreement with @EdinburghUni

Read Guy's paper at https://t.co/v1b42FFBVn

Is your institution also participating? https://t.co/WpJcxTt3x8

[Keith Matthews @KeithRMatthews]

A tough task in lockdown to cover this enormous topic but Eleanor Silvester & @Frank_Venter rose to the challenge.
Parasite co-infection: an ecological, molecular and experimental perspective | Proceedings of the Royal Society B: Biological Sciences https://t.co/W6i50mSq94