Marija Krasiļņikova

Parasitologist | McCulloch Lab @ University of Glasgow

[Jeziel D. Damasceno @jezielbqi]

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.

https://t.co/CNKlADxFBn

Big thanks to Mike Boemo

[Carlos Robello @carlos_robello]

32 T2T!!!
Happy to share our preprint showing the molecular karyotype of #Trypanosomacruzi
@GonzaloGreif @fdiazviraque #MariaLChiribao @CarlosSanz22

@PacBio HiFi
https://t.co/k1huOmWnpJ

[Marija Krasiļņikova @scotomorph]

More recent work from the McCulloch lab! Check out Jeziel's @jezielbqi recent paper on R-loops, DNA replication and genomic stability in Leishmania major https://t.co/8ROyEJ4zEM in @NatureComms @McCulloch_Group @MarquesCata @rmc9z @emmabriggs6

[Marija Krasiļņikova @scotomorph]

@jezielbqi @McCulloch_Group @emmabriggs6 @MarquesCata Woop woop!

[Jeziel D. Damasceno @jezielbqi]

Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published!

https://t.co/gxjTlp7r8B

@McCulloch_Group @emmabriggs6 @scotomorph @MarquesCata

[McCulloch Lab Group @McCulloch_Group]

We're pleased to share a new paper @UofGSii @WCIPGLASGOW led by @scotomorph @MarquesCata where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome. Well done Marija!
https://t.co/6npgzQdG1s

[Marija Krasiļņikova @scotomorph]

@JoanaRCF @rmc9z @MarquesCata @emmabriggs6 Thank you 🖤

[Marija Krasiļņikova @scotomorph]

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! https://t.co/FEoM8PUm23 thanks to @rmc9z @MarquesCata @emmabriggs6 Dario, Kathryn, Graham and Craig! 🥳

[Trends in Parasitology @TrendsParasitol]

Drs Stephen Larcombe @jane_munday & @rmc9z highlight @MonicaMugnier & colleagues’ @Nature article on tissue spaces as #reservoirs of #AntigenicDiversity for #Trypanosoma #brucei. @SBSatEd @WCIPGLASGOW @UofGSii @JohnsHopkinsMMI @JohnsHopkinsSPH #Trypanosome
https://t.co/Rn7TMNkxMn

[Marija Krasiļņikova @scotomorph]

@jezielbqi @McCulloch_Group @gabriellamak @MarquesCata @WCIPGLASGOW Spoiler alert in the title, heh

[Joana Faria @JoanaRCF]

Are you interested in genome maintenance, organisation and replication?
We have a BBSRC-funded PhD position to use multi ‘omics’ approaches to tackle this problem! ⁦@McCulloch_Group⁩ ⁦@UniOfYork⁩ ⁦@YBRI_UoY⁩ https://t.co/k0FO8KuoL6

[Jeziel D. Damasceno @jezielbqi]

Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At @McCulloch_Group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇

[Marija Krasiļņikova @scotomorph]

How does Leishmania major replicate its genome? A sneaky Sneak Peek at a recent manuscript from our lab @McCulloch_Group (led by Jeziel @jezielbqi) currently under review:

https://t.co/sk5OZmzpcN

[Marija Krasiļņikova @scotomorph]

@OlympiaMHardy Woop woop!

[McCulloch Lab Group @McCulloch_Group]

Very happy to share new work @UofGSii @WCIPGLASGOW led by @jezielbqi describing very abundant, previously undetected DNA replication activity in Leshmania using DNAscent, a technique developed by @CNieduszynski Great work, Jeziel.
https://t.co/vPjJf5cXSj

[McCulloch Lab Group @McCulloch_Group]

Funded PhD available with us, @martllewellyn and James Cotton @UofGSii @UofGSBOHVM @WCIPGLASGOW to study genome replication and (in)stability across diverse kinetoplastids. Applications (via FindaPhD) taken from Nov 1st - Jan 12th. Enquiries welcome.
https://t.co/Cow8ywjqD5

[Marija Krasiļņikova @scotomorph]

Is 915 jupyter notebook cells an indication that it's time to move on to analysing some other data?

[McCulloch Lab Group @McCulloch_Group]

Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6

https://t.co/3EpybzkLkj

[McCulloch Lab Group @McCulloch_Group]

We’re pleased to share a new study led by @jezielbqi describing how R-loops and RNase H1 dictate chromosome size-dependent DNA replication timing and genome stability in Leishmania @emmabriggs6 @scotomorph @MarquesCata
https://t.co/2ak36oRL6z

[Marija Krasiļņikova @scotomorph]

And this one's doing cartwheels

[Marija Krasiļņikova @scotomorph]

This trypanosome chromosome looks like it's having a great time, no?