Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
https://t.co/CNKlADxFBn
Big thanks to Mike Boemo
Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published!
https://t.co/gxjTlp7r8B
@McCulloch_Group@emmabriggs6@scotomorph@MarquesCata
We're pleased to share a new paper @UofGSii@WCIPGLASGOW led by @scotomorph@MarquesCata where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome. Well done Marija!
https://t.co/6npgzQdG1s
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! https://t.co/FEoM8PUm23 thanks to @rmc9z@MarquesCata@emmabriggs6 Dario, Kathryn, Graham and Craig! 🥳
Are you interested in genome maintenance, organisation and replication?
We have a BBSRC-funded PhD position to use multi ‘omics’ approaches to tackle this problem! @McCulloch_Group @UniOfYork @YBRI_UoY https://t.co/k0FO8KuoL6
Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At @McCulloch_Group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇
How does Leishmania major replicate its genome? A sneaky Sneak Peek at a recent manuscript from our lab @McCulloch_Group (led by Jeziel @jezielbqi) currently under review:
https://t.co/sk5OZmzpcN
Very happy to share new work @UofGSii@WCIPGLASGOW led by @jezielbqi describing very abundant, previously undetected DNA replication activity in Leshmania using DNAscent, a technique developed by @CNieduszynski Great work, Jeziel.
https://t.co/vPjJf5cXSj
Funded PhD available with us, @martllewellyn and James Cotton @UofGSii@UofGSBOHVM@WCIPGLASGOW to study genome replication and (in)stability across diverse kinetoplastids. Applications (via FindaPhD) taken from Nov 1st - Jan 12th. Enquiries welcome.
https://t.co/Cow8ywjqD5
Our new study led by @scotomorph@MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81@emmabriggs6
https://t.co/3EpybzkLkj
We’re pleased to share a new study led by @jezielbqi describing how R-loops and RNase H1 dictate chromosome size-dependent DNA replication timing and genome stability in Leishmania @emmabriggs6@scotomorph@MarquesCata
https://t.co/2ak36oRL6z