hetzer

anti-extremist

[nature @Nature]

A scientist in training seeks help in finding a new adviser without damaging existing working relationships

https://t.co/WpkUauVHRF

[UCLA Neuroscience Theme @UCLANeuroTheme]

What if you could explore an entire brain at nearly the scale of individual cells? Researchers including UCLA neuroanatomist Hong-Wei Dong created a 3D mouse brain atlas with 1-μm resolution, mapping 916 brain structures in remarkable detail. The atlas could help researchers more precisely locate cells and connections throughout the brain. More 👇 https://t.co/rDVc66iXC4. #UCLA #Neuroscience #BrainMapping #Neuroanatomy

[nature @Nature]

Nature research paper: Identification of broadly tumour-reactive γδ TCRs from multiple myeloma

https://t.co/ABauYNnRbE

[nature @Nature]

Nature research paper: Electrically controllable superconducting memory effect in UTe2

https://t.co/3FXbtqpwAL

[☠️Herr Von Kaiser V☠️ @KaiserAtlantean]

A Dutch boy fights off a feral pack of camel jockeys like a true Aryan warrior.

[El Errante @elerrantenomad]

wtf Houthis are doing here?

What’s the context ?

[Magahalla @Magahalla]

“Bring the KKK back!”

[Magahalla @Magahalla]

“Bring the KKK back!”

[Nature Metabolism @NatMetabolism]

mRNA methylation safeguards pancreatic α-cell identity against cellular plasticity https://t.co/7dEicyYIds

[nature @Nature]

Nature research paper: A thermodynamically favoured molecular computer

https://t.co/URXt6RHnii

[עטרה @cherutLmoledet]

"Ancient men conquered cities put them to the sword and fire"

Real men still do

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

基底細胞様乳癌は核異型を示すが、高頻度で観察されるコピー数異常をマウス体内で再現するCRISPR-KOALAスクリーニング（3750遺伝子が標的）によって90以上の新規癌関連遺伝子を同定したという論文。WNT, HIPPO, MAPKなど多様な信号系の活性化が確認されたとか。Nature。
https://t.co/8DLKNFjOzJ

[Nature Chemical Biology @nchembio]

Allenes and alkynes can be biosynthesized via oxidative C(sp2)-demethylation of a prenyl group by fungal cytochrome P450s, expanding the catalytic repertoire of P450 enzymes

https://t.co/42k6Vh0TpA

[🤺JUDENWAFFEN EMPEROR 🌞 @medbazongas]

Shabbat Shalom from the Zog Panzer Corps

[Liberator @Elden_to]

"Islam gave more rights to women 1400 years ago than Christian women had 100 years ago"

[Peter Du @peterdu_]

CRISPR screens are great at telling you what a gene is doing inside your cells. But what if you're interested in what's happening to its neighbors?

Today, I'm excited to share match-seq, a new method that deciphers cell-cell interactions using barcoded RNA transfer.
1/9

[AutoAdmit @autoadmitdotcom]

they out here eating gaza strip on a bun

[drug hunter @drughunter_com]

Weekend reading from the archive. Open access.
Bioisosteres for Drug Hunters: Part I - Background, Carboxylic Acids, and Amides

Bioisosteric replacement is a powerful strategy in medicinal chemistry, enabling the optimization of key molecular properties such as potency, selectivity, solubility, membrane permeability, and metabolic stability, while mitigating off-target toxicity. 

By mimicking the size, shape, and electronic properties of original functional groups, bioisosteres can enhance drug-like characteristics and contribute to novel intellectual property in drug discovery. 

In this first installment of our bioisosteres series, we delve into the critical role of carboxylic acid and amide bioisosteres—two of the most extensively studied functional groups in drug design. 
Through real-world insights and case studies, we examine how these substitutions influence drug properties, improve oral bioavailability, and reduce potential liabilities, ultimately shaping the success of modern therapeutics.

Read the full article now: https://t.co/tdACtr7oqe