Haematopoiesis and Immunity Lab

Haematopoiesis and Immunity Lab, Translational and Clinical Research Institute

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

It has been great working with @ImogenFranklin6, @sarahjpickett, Oliver Russell, @MitoResearch on this project showing that T cell differentiation drives the negative selection of pathogen mtDNA variants in mitochondrial disease! https://t.co/zEXMeF9KTJ

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

We are very happy to have been involved in this worldwide, genome-wide study of Erdheim Chester Disease. Demonstrating that germline genetic variants can impact on the development of ECD and suggesting new pathways with a potential pathogenic role. https://t.co/6aabbHiSdI

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

And Callum with host versus graft DP-mismatching: those resident T cells may be at the root of GVHD tissue tropism . . . https://t.co/BBfNFQHpPT

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Paul's latest paper on lineage-switch in Langerhans cell histiocytosis: https://t.co/5ms5PxbSPr

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Congratulations to Dr Callum Wright on the publication of this paper! 🎉🎉

"Host versus graft HLA-DP1 mismatching promotes graft versus host disease"

https://t.co/VG4E8Ardbm

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

The origins of LCH revealed: https://t.co/2pDnojA7Xj

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Many thanks to @EgleKvedaraite for getting us involved in this great study!

[Egle Kvedaraite @EgleKvedaraite]

Myeloid lineages talk to each other and it’s anything but small talk

We found their Notch dependent cross-talk promote Langerhans Cell Histiocytosis pathology
Now out in @SciImmunology @FGinhoux 🧵https://t.co/e3m4nrNJ7X

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Congrats Egle, Florent and Paul @HI_Lab_NCL and all the team for a key insight into histiocytosis and DC at Science Immunology https://t.co/DYKmwbxJIl

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology https://t.co/AZ5HE5cZAx

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

60% of Langerhans Cell Histiocytosis patients have the BRAFV600E mutation; found in myeloid cells. We show that the remaining patients also carry mutations in myeloid cells, suggesting that treatment strategies may be similar regardless of mutation. https://t.co/0orjwam1yQ

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Histiocytosis patients can be treated with targeted inhibitors but long-term side effects are unknown and relapses can occur after treatment withdrawal. We show mutated cells switch over time, potentially indicating when it is safe to withdraw treatment. https://t.co/EallnyAjzL

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Great new paper in collaboration with @sbomken discussing the epigenetic regulation of lineage switching leukaemia and getting the cover image! https://t.co/Zn3XV3kfe1

[Urszula Cytlak @UCytlak]

#BSI22
Lovely plenary session by @vhbigley, a beautiful story of IRF8 -dependent DC haematopoiesis in the innate inborn immunodeficiencies

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Me and the boys

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Take a look at our newly published review #immunodeficiency #dendriticcells https://t.co/kzZRmVwhkd

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Beautiful morning for our away day in Cullercoates @NCLDoveMarine

[Paul Milne @DrPaulMilne]

Our new blood test in #Newcastle could offer a quicker, cheaper, painless way to detect #Leukemia #bloodcancer #aml. Currently we’re in the top 5% of altmetrics while under review! Please RT. https://t.co/8BLs50ZjHx

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

See a preview of our latest paper defining human dendritic cell development - Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans https://t.co/kswn8CpjHt

[Matthew Collin @MatthewCollin]

Read our paper here describing a simple blood test to follow treatment response #bloodcancer #leukemia Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia https://t.co/BM6sWoeZL8 thank you @CRUK @BrightRedOrg for funding

[Haematopoiesis and Immunity Lab @HI_Lab_NCL]

Read our latest paper on a simple prognostic blood test for monitoring AML - Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia https://t.co/AHQvFUKerx