It has been great working with @ImogenFranklin6, @sarahjpickett, Oliver Russell, @MitoResearch on this project showing that T cell differentiation drives the negative selection of pathogen mtDNA variants in mitochondrial disease! https://t.co/zEXMeF9KTJ
We are very happy to have been involved in this worldwide, genome-wide study of Erdheim Chester Disease. Demonstrating that germline genetic variants can impact on the development of ECD and suggesting new pathways with a potential pathogenic role. https://t.co/6aabbHiSdI
Congratulations to Dr Callum Wright on the publication of this paper! 🎉🎉
"Host versus graft HLA-DP1 mismatching promotes graft versus host disease"
https://t.co/VG4E8Ardbm
Myeloid lineages talk to each other and it’s anything but small talk
We found their Notch dependent cross-talk promote Langerhans Cell Histiocytosis pathology
Now out in @SciImmunology@FGinhoux 🧵https://t.co/e3m4nrNJ7X
60% of Langerhans Cell Histiocytosis patients have the BRAFV600E mutation; found in myeloid cells. We show that the remaining patients also carry mutations in myeloid cells, suggesting that treatment strategies may be similar regardless of mutation. https://t.co/0orjwam1yQ
Histiocytosis patients can be treated with targeted inhibitors but long-term side effects are unknown and relapses can occur after treatment withdrawal. We show mutated cells switch over time, potentially indicating when it is safe to withdraw treatment. https://t.co/EallnyAjzL
Great new paper in collaboration with @sbomken discussing the epigenetic regulation of lineage switching leukaemia and getting the cover image! https://t.co/Zn3XV3kfe1
Our new blood test in #Newcastle could offer a quicker, cheaper, painless way to detect #Leukemia#bloodcancer#aml. Currently we’re in the top 5% of altmetrics while under review! Please RT. https://t.co/8BLs50ZjHx
See a preview of our latest paper defining human dendritic cell development - Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans https://t.co/kswn8CpjHt
Read our paper here describing a simple blood test to follow treatment response #bloodcancer#leukemia Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia https://t.co/BM6sWoeZL8 thank you @CRUK@BrightRedOrg for funding
Read our latest paper on a simple prognostic blood test for monitoring AML - Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia https://t.co/AHQvFUKerx