Hadeesha Piyadasa

Postdoc @Bendall_Lab @MikeAngeloLab @Stanford

[Hadeesha Piyadasa @HadeeshaP]

Thrilled to share that our paper is out in @Cancer_Cell: We apply spatial proteomics, transcriptomics, and glycomics to define tumor antigens, TME organization, and predictors of grade and survival.

https://t.co/6CNTb1A6V9

[Arc Institute @arcinstitute]

Most spatial CRISPR screens require trade-offs in throughput or readout depth. A new preprint from @alexnevue, @Inna_Averbukh, @Davidlarastiaso & team introduces PerturbSpace: spatially resolved, multimodal, whole-transcriptome on standard single-cell workflows.

[Hadeesha Piyadasa @HadeeshaP]

For a deeper dive into how we built this and what we found, check out the preprint post below 👇

https://t.co/IUQlLWqVc1

[Hadeesha Piyadasa @HadeeshaP]

🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have shown limited response to immunotherapy and targeted treatments compared to other malignancies. #GliomaResearch #NeuroOncology #CancerImmunotherapy https://t.co/pE7ocTqgbj

[Hadeesha Piyadasa @HadeeshaP]

Thrilled to share that our paper is out in @Cancer_Cell: We apply spatial proteomics, transcriptomics, and glycomics to define tumor antigens, TME organization, and predictors of grade and survival.

https://t.co/6CNTb1A6V9

[Noah F. Greenwald @NoahGreenwald]

Thrilled to share that Nimbus, our method to robustly identify cell positivity in multiplexed imaging data, is out @naturemethods! If you've struggled with cell clustering/phenotyping in imaging data, please give it a try. https://t.co/PjmBqAVrtv

[Hadeesha Piyadasa @HadeeshaP]

(8/8) All this work would not have been possible without all the amazing people at @Bendall_Lab and @MikeAngeloLab and our collaborators. Mikaela Ribi, Ke Leow @JoleneRanek @Inna_Averbukh @meeladamouzgar @CandaceCLiu @NoahGreenwald Erin McCaffrey @rashmikumar559 Albert Tsai @MarcBosse5 @OkadaLabUCSF1 @OldridgeDerek

[Hadeesha Piyadasa @HadeeshaP]

🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have shown limited response to immunotherapy and targeted treatments compared to other malignancies. #GliomaResearch #NeuroOncology #CancerImmunotherapy https://t.co/pE7ocTqgbj

[Hadeesha Piyadasa @HadeeshaP]

(7/8) Open source spatial multi-omics of human gliomas: We have made everything in this study freely available through the BRUCE data portal–a user-friendly web resource for quantitative analysis and
visual data exploration of all extracted features and multiparameter imaging data - https://t.co/4v4WCKgbEO. For more details, check out the preprint - https://t.co/pE7ocTqgbj

[Jolene Ranek @JoleneRanek]

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) https://t.co/wVcOrwL6A1

[Noah F. Greenwald @NoahGreenwald]

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) https://t.co/5bajDEQ2rP

[Patricia Favaro @favaropb]

I am thrilled to share my preprint with @Bendall_Lab that includes a new and comprehensive phenotypic atlas of human hematopoietic progenitor cells. Check out how we reconcile the diversity of human HSPCs in the tweetorial below. https://t.co/QuvYb9b2eQ

[Michael Angelo @MikeAngeloLab]

Save the Date! Please join us in August for our 2nd Annual Spatial Biology Workshop! @_hubmap @ncihtan #spatialbiology @WellcomeLeap

[Hadeesha Piyadasa @HadeeshaP]

@BryJCannon 🤣 one too many times

[Michael Angelo @MikeAngeloLab]

Our new @_hubmap study examining how the maternal fetal interface is established in human pregnancy is out! Big effort led by @Inna_Averbukh, @ErinSoon_ , @ShirleyGreenba1. So proud of the beautiful study they completed!

https://t.co/glIB02VHid

[Dunja Mrdjen @Dunja_Mrdjen]

Thrilled to share the preprint from my postdoc work in the @Bendall_Lab with @MikeAngeloLab and Thomas Montine at @StanfordMed looking at human microglia in situ in #aging and #Alzheimers disease by multiplexed proteomic imaging! https://t.co/L5OFsN9zAy

[SpaceX @SpaceX]

Watch Starship’s first integrated flight test → https://t.co/bJFjLCiTbK https://t.co/14MZeMTApK