Michael Angelo

Pathology and computational biology through engineering and applied physics

[Michael Angelo @MikeAngeloLab]

Registration for the 3rd Annual Spatial Biology Summit is now open! Don't miss out! Hope to see you in September.

[Michael Angelo @MikeAngeloLab]

Glad to see this one out! Thank you @parkerici and all our collaborators for supporting this work.

[Hadeesha Piyadasa @HadeeshaP]

Thrilled to share that our paper is out in @Cancer_Cell: We apply spatial proteomics, transcriptomics, and glycomics to define tumor antigens, TME organization, and predictors of grade and survival.

https://t.co/6CNTb1A6V9

[Michael Angelo @MikeAngeloLab]

I love this paper.

[Niko McCarty. @NikoMcCarty]

What limits a cell's size?

One factor (and I'll explore others in an upcoming essay) is its surface area-to-volume ratio. A semi-spherical cell's internal volume grows proportionally to the cube of its radius, and its surface area grows proportionally to the square of that radius. A cell’s volume thus grows much more swiftly than its surface area.

This ratio has serious consequences for cellular survival, though. The cell’s membrane funnels nutrients into the cell and secretes waste. So if the interior grows too large relative to the cell membrane, the cell’s metabolic processes slow to a crawl.

A new study reveals that some mammalian cells have evolved a mechanism to keep their surface area-to-volume ratio CONSTANT even as the cell grows. They do this by folding their plasma membranes hundreds of times to increase *effective* surface area, thus helping them maintain high levels of nutrient uptake.

There are other ways to get around this limit, too. Case in point: a giant bacterium called Thiomargarita magnifica can exceed one centimeter in diameter, so large that it is visible by the naked eye. It does so by filling between 65-80 percent of its internal volume with an empty vacuole. In other words, it pushes most of its “working” molecules to the cell periphery, thus shortening diffusion distances.

All this, and much more, in a forthcoming essay for @AsimovPress.

[Michael Angelo @MikeAngeloLab]

Also! In collaboration with @parkerici, we have created a web portal to make all this data as accessible as possible. You can run your own queries or download the dataset in its entirety: https://t.co/CuV3vc1Slg

[Hadeesha Piyadasa @HadeeshaP]

🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have shown limited response to immunotherapy and targeted treatments compared to other malignancies. #GliomaResearch #NeuroOncology #CancerImmunotherapy https://t.co/pE7ocTqgbj

[Michael Angelo @MikeAngeloLab]

Preprint of our multicenter study of human gliomas is out! Big thank you to @parkerici @CancerResearch @ACGTFoundation for supporting this work.

[Hadeesha Piyadasa @HadeeshaP]

🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have shown limited response to immunotherapy and targeted treatments compared to other malignancies. #GliomaResearch #NeuroOncology #CancerImmunotherapy https://t.co/pE7ocTqgbj

[Michael Angelo @MikeAngeloLab]

Wonder how many of my scientist friends still on here manage to ignore my alien posts. Read the article! We are supposed to be curious!

https://t.co/Fp6ugVSVox

[Michael Angelo @MikeAngeloLab]

“None of the government leadership I spoke to — who have access to very sensitive classified information — were debating whether this is real. None of them.”

Just sayin’

https://t.co/ANtSSYyDWn

[Michael Angelo @MikeAngeloLab]

You just spoke to my soul! If @DOGE actually wants to improve the NIH they should listen to this

[Jason Abaluck @Jabaluck]

RE: reforming NIH funding, my view is -- keep total $ the same or increase it, but:
a) Do fast review (<1 month) based on 2 page applications & email exchanges for clarifying questions
b) Give $ directly to investigators with broad discretion aside from "don't pocket it"

[Michael Angelo @MikeAngeloLab]

Wow.

[NIH @NIH]

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.

[Michael Angelo @MikeAngeloLab]

@JosCRios @BillyKryzak

[Michael Angelo @MikeAngeloLab]

Check out another great one from @NoahGreenwald where we look at spatial predictors of response to anti-PD1 in TNBC!

[Noah F. Greenwald @NoahGreenwald]

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) https://t.co/5bajDEQ2rP

[Michael Angelo @MikeAngeloLab]

@GarryPNolan @sama totally agree with this and that it will be genuintely useful, but "curing diseases at an unprecedented rate" is something different all together.

[Michael Angelo @MikeAngeloLab]

I take it @sama has never done a western blot before. Bottleneck isn't new ideas its testing them.

[vittorio @IterIntellectus]

sam altman: “we will see diseases get cured at an unprecedented rate … what this will do to cure the diseases at a rapid rapid rate”

immortality is not too far ahead. we live in the most incredible of times

[Michael Angelo @MikeAngeloLab]

Critical mass of high ranking people in USGOVT are all saying the same thing: UFOs are real and we've been studying them in secret for decades. The scientific community needs to engage and get up to speed https://t.co/VyrtIawLO0

[Michael Angelo @MikeAngeloLab]

More ex-military coming forward saying govt is hiding long running UFO research program
https://t.co/sb0TyXw4vh

[Michael Angelo @MikeAngeloLab]

Jolene has done amazing work here. QUICHE is a dramatic improvement over cell neighborhood algos we've used in the past, gets immediately to a common question we ask often: how does spatial structure between two patient groups differ?

[Jolene Ranek @JoleneRanek]

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) https://t.co/wVcOrwL6A1

[Michael Angelo @MikeAngeloLab]

@GarryPNolan @disclosureorg @NJGov It is interesting. But FYI Reddit entry says this occurred in the countryside of England, not NJ.

[Garry P. Nolan @GarryPNolan]

I am deeply honored to be named by the Stanford Medicine Alumni Association this year for the “Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences.”

As a Stanford graduate student in the 1980s, I took a remarkable class in plasmid and phage replication from Dr. Kornberg. I marveled at his incisive manner of teaching complex concepts in science. I learned fundamentals of retroviral gene transfer from postdoctoral fellows and technical staff in Dr. Berg’s laboratory. I was in constant awe of Dr. Berg’s statesmanship on the world stage as a spokesman for science.

Arthur Kornberg, M.D. and Paul Berg, Ph.D. were luminaries long before I was a graduate student. Professor Kornberg won the Nobel in Physiology or Medicine for isolating DNA polymerase and demonstrating how it could replicate DNA in a test tube. Professor Berg won the Nobel in Chemistry by showing the first inter-species DNA hybrid of bacterial and eukaryotic viral DNA and replicating it in bacteria. Professor Berg was instrumental in pointing out the dilemmas around recombinant DNA at the foundational Asilomar Conference in 1975, a critical meeting focusing on the ethical uses of rec-DNA technology.

Dr. Kornberg’s and Dr. Berg’s efforts deeply touched biomedical sciences and helped patients worldwide. They symbolized science's dual role in fundamental discovery and service to humanity.

[Michael Angelo @MikeAngeloLab]

NPR: Second congressional hearing where former US military and intelligence officials give sworn testimony that the govt has been running a secret UFO crash retrevial program for decades
https://t.co/i5O7uS25K3

[Michael Angelo @MikeAngeloLab]

Great new Stanford PI doing cutting edge spatial biology! Congrats Guolan on your new lab!

[Guolan Lu @GuolanLu]

Please RT. I am currently hiring graduate students and postdoc fellows. Details can be found here: https://t.co/eU2Xk0g07u My lab is dedicated to developing and integrating imaging, AI, and spatial omics technologies to uncover mechanisms driving disease initiation, progression, and therapeutic response, with the ultimate goal of advancing next-generation theragnostics to cure diseases. We are excited to be equipped with cutting-edge spatial omics technologies, including Xenium spatial transcriptomics @10xGenomics and Phenocycler-fusion @AkoyaBio .

[Michael Angelo @MikeAngeloLab]

It’s finally here!! See everyone tomorrow!

[Candace Liu @CandaceCLiu]

We are only TWO WEEKS away from the start of the Spatial Biology Summit! It's not too late to register! We are still accepting poster abstracts until the end of this week. More info here: https://t.co/87TUbReg4L

@MikeAngeloLab @Bendall_Lab