Hafezparast Lab

Based at the University of Sussex, we are working on understanding motor neurone diseases to help improve diagnosis and lead to new treatments.

[Hafezparast Lab @HafezparastLab]

Delighted to share our latest paper 'Severe dynein dysfunction in cholinergic neurons exacerbates ALS-like phenotypes in a new mouse model'. Read at https://t.co/MpNL958zJA
Funded by MND Association @mndassoc

[Sussex RNA Network @SussexRNA]

🚀 Exciting new publication from the Hafezparast Lab! @ProfHafezparast
📄They explore how an ALS-associated TDP-43 mutation affects microglia-derived miRNAs after LPS stimulation.

Read the full paper here:

https://t.co/tUqh35dyTT

#ALS #SussexRNA #RNA #Neuroscience

[Hafezparast Lab @HafezparastLab]

Delighted to share our latest @DMM_Journal paper 'The ALS-associated TDP-43M337V mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner'. Read at https://t.co/lrIC8SoJN8

[MND Research @PremiumXRemark]

#ResearcherSpotlight💡

PhD student Sarah Gornall is investigating whether small changes in a combination of several genes can lead to the development of #MND #ALS. 🧬

Learning more about genetics in MND could lead to new potential therapies.

Read more: https://t.co/ABXWQ2mhEt

[Hafezparast Lab @HafezparastLab]

Are you interested in discovering non-coding RNA biomarkers for early diagnosis of motor neuron disease? If yes, apply for a postdoc with us on a @LifeArc funded project @SussexNeuro @SussexLifeSci
https://t.co/7k1az2rgUE

[SussexNeuro @SussexNeuro]

Our Sussex Neuroscience 4-year PhD Programme is open for applications! Deadline Feb 19th, for Sept 2024 entry. Brilliant community of students and supervisors, and a choice of >50 labs for rotations- come and join us by the sea! https://t.co/KH6R7yR5Tt

[Katrin Deinhardt @KatrinDeinhardt]

We have a fully funded @SoCoBioDtp studentship advertised, together with my wonderful colleagues @TheWangLab and @HafezparastLab. If interested, you can find out more here:
https://t.co/TukNWHPhKV
Deadline: 8th January 2024

[Hafezparast Lab @HafezparastLab]

Just a reminder that you have one week left to apply for this position in our group! Why not come join us on the South Coast to investigate biomarkers for MND?

[Hafezparast Lab @HafezparastLab]

How would you like to come to @SussexLifeSci @SussexNeuro and work on a @mndresearch-funded project looking at identifying ncRNA biomarkers in MND using a clinical trial cohort? If that interests you, then come apply for a postdoc with us for two years!
https://t.co/upWVhPHRhW

[Hafezparast Lab @HafezparastLab]

How would you like to come to @SussexLifeSci @SussexNeuro and work on a @mndresearch-funded project looking at identifying ncRNA biomarkers in MND using a clinical trial cohort? If that interests you, then come apply for a postdoc with us for two years!
https://t.co/upWVhPHRhW

[Hafezparast Lab @HafezparastLab]

After seven years of incredible research into MND, Dr Greig Joilin is starting a new path as a lecturer. It has been an absolute pleasure to have him in my team & witness his exceptional talents & dedication to make a difference. Thank you Greig and all the very best for future!

[Hafezparast Lab @HafezparastLab]

She interestingly found that mutant dynein with normal human TDP-43 showed no mislocalisation of the protein, but did show aggregation of TDP-43 in the spinal motor neurons, along with p62 upregulation. These findings provide new insights between dynein and TDP-43.

[Hafezparast Lab @HafezparastLab]

Proud to share our latest @tandfonline paper “Aberrant Dynein Function Promotes TDP-43 Aggregation and Upregulation of p62 in Male Mice Harboring Transgenic Human TDP-43.” Investigates axonal transport in #ALS. Read it at https://t.co/IQ12MNSufa

[Hafezparast Lab @HafezparastLab]

In work done by @EleniVChristof as part of her PhD, she investigated whether mice with mutations in both TDP-43 and dynein would cause TDP-43 cytoplasmic mislocalisation and protein aggregation, which although is a key ALS pathology, is not observed in most TDP-43 mouse models.

[Majid Hafezparast @ProfHafezparast]

A great pleasure to supervise our fantastic Sussex Neuroscience PhD student Eleni Christoforidou @EleniVChristof and to celebrate her graduation with her. Many congratualtions Eleni @SussexNeuro @SussexLifeSci

[SussexNeuro @SussexNeuro]

Great opportunity to join our Neuroscience faculty (Research and Education Lectureship) at the University of Sussex: Deadline extended to August 15. https://t.co/WStSTjqreP

[MND Research @PremiumXRemark]

Last night at the #ENCALS2023 poster session, the team caught up with a number of @mndassoc funded researchers!

Amazing to see so many of our #MND #ALS researchers presenting their work and making new connections! 👩‍🔬👨‍🔬

Here are just a few we caught on camera 📷

[My Name'5 Doddie Foundation @MNDoddie5]

We've been catching up with @DrGreigJoilin & @hellychayts at ENCALS about their projects that were supported by the Foundation 🔬

Thank you both for your continued work in MND research and helping us to make our vision a reality.

[Hafezparast Lab @HafezparastLab]

And so our time at #ENCALS2023 comes to an end. A great few days of networking, sharing our work, learning about the exciting work being done everywhere else, and enjoying the sunshine and hospitality in Barcelona!

[Hafezparast Lab @HafezparastLab]

So please come along, see what we found and have a chat with us - we'll try to be there while trying to catch a look at all the other exciting posters at #ENCALS2023!

[Hafezparast Lab @HafezparastLab]

We are at #ENCALS2023 and ready to share some of the work that we have been doing over the last couple of years with three posters over the next two evenings!

[Hafezparast Lab @HafezparastLab]

And lastly, we have @DrGreigJoilin who is presenting his @MNDoddie5 and @mndresearch funded work looking to find prognostic and progression non-coding RNA biomarkers using a longitudinal results and has some promising results.