Thrilled to witness two giants, @NogalesLab and @mpgpresident, being honored at the @ShawPrize ceremony for their outstanding contributions to the transcription field!
The +1 nucleosome can slide upstream to induce an inactive conformation of TFIIH and reduce transcription activity. Congratulations to @JAbrilGarrido@c_dienemann@HaiboWang36@lidschreiber
https://t.co/qFQCkrSXeb
Let's see how a promoter-proximal +1 nucleosome impairs transcription initiation, Julio has a nice answer. Congratulations and well deserved! @JAbrilGarrido 🎉🎉🎉. Special thanks to Patrick @CramerLab for his great support on this project.
A promoter-proximal +1 nucleosome meets the human RNA polymerase II pre-initiation complex (PIC), and it does so in various ways! Happy to finally see the bulk of my PhD thesis at @mpi_nat @CramerLab out online in @MolecularCell. A sneak peek below (1/n)
https://t.co/cK7v26Lg74
High-resolution structure of yeast Pol II PIC-Mediator complex reveals ~half of the C-terminal domain (#CTD). Great effort by @S_Schilb@HaiboWang36@c_dienemann
https://t.co/LLyz46ehkq
Saying good-bye to @HaiboWang36 and wishing him all the best as a PI at @ZJU_China. Remembering his wonderful work on chromatin-associated factors:
https://t.co/q6HbhPcA6v
https://t.co/L6ylxm92zV
https://t.co/74gE4xiVZr
Transcription-coupled DNA repair: After a long journey, we can now see how CSA, CSB, UVSSA and CRL4 remodel the transcribing Pol II complex for ubiquitination and DNA repair. Masterpiece by @KokicGoran.
https://t.co/G2UgJwR5rd
Unexpected finding that TBP can recognise nucleosomal TATA box and function like a pioneer factor. It will be exciting to see people who are interested in TBP's function figuring out the in vivo relevance in the future.