The Nogales Lab

The Nogales Lab at UC Berkeley. #CryoEM #Transcription #Microtubules #ChromatinModification #Telomerase Twitter account managed by lab members.

[The Nogales Lab @NogalesLab]

Thrilled to share our latest work, led by @aryandtaheri and @jpeukes! Using #cryoEM and #cryoET, we reveal how KIF21B’s distal tail engages multiple tubulin dimers along a protofilament, enabling persistent microtubule attachment and crosslinking.

https://t.co/nNpNWpE3Ei

[The Nogales Lab @NogalesLab]

https://t.co/elXTn2UakO

[The Nogales Lab @NogalesLab]

Thrilled to share our collab with @GraceHibshman and the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.

[The Nogales Lab @NogalesLab]

#microtubules #cryoEM #tubulincode #cellbiology #neuroscience #zebrafish #structuralbiology #biorxiv
11/n

[The Nogales Lab @NogalesLab]

🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by @Juanmabertoldi1 and Julie Dang spanning atoms to organisms. 1/n

[The Nogales Lab @NogalesLab]

Full text here: https://t.co/MJKKR9Ouyz

@Juanmabertoldi1, Julie Dang, Mert Golcuk, Eva Lanska, @lopesdanilo11, Veronique Henriot, Jingyi Luo, @RuiZhangWUSTL, @JeffTiLab, @CarstenJanke, Zdenek Lansky, @PittGurLab, @filodelbene, @NogalesLab 10/n

[The Nogales Lab @NogalesLab]

Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science https://t.co/H0qOFKGkCd

I am truly honored to receive this prize and incredibly grateful to have worked with so many talented lab members over the years.🙏👩‍🎓🧑‍💼

[The Nogales Lab @NogalesLab]

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study!

https://t.co/PvkIsebXbM

[The Nogales Lab @NogalesLab]

@berkeleyMCB

[The Nogales Lab @NogalesLab]

Congrats to Ana Galic and Kevin Li, who just graduated with honors in MCB, and to the brand new Dr. Trinity Cookis @trincookis 👨‍🎓👩‍🎓👩‍🎓🤩. Very best wishes for your next endeavors 💝.

[The Nogales Lab @NogalesLab]

Congrats to my @berkeleyMCB colleague @AndyMartinLab who just received the Dorothy Crowfoot Hodgkin Award of the @ProteinSociety. Andy's studies have made the proteasome one of the best understood molecular machines in biology. Well deserved!! 🥳🥳

[The Nogales Lab @NogalesLab]

Another fabulous PEW meeting, this year at Palm Springs. So lovely to share time with both exlab members @vignesh_k757 and @kellogg_liz and @UCBerkeley colleagues. LatinAmericanFellows, please send me photos by email! Science was simply wonderful!! 🧬🥇