Shih-Chieh (Jeff) Ti

Assistant Professor @ University of Hong Kong, School of Biomedical Sciences

[Shih-Chieh (Jeff) Ti @JeffTiLab]

A new research article from the TI Lab.
https://t.co/WrF7WICzh6

In this article, we reveal the molecular mechanism by which a specific tubulin isotype renders cancer cells resistant to paclitaxel, a WHO-listed essential medicine for cancer treatment.

[Chul KWON @schul_kwon]

Excited to share our latest work on high-resolution comparative RNA knockdown profiles of shRNA, CasRx, and PspCas13b systems! https://t.co/cAI3xsMQqt

[Alushin_Lab @Alushin_Lab]

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature

https://t.co/gzEziWL8aB

[Alushin_Lab @Alushin_Lab]

Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.

https://t.co/7GoQA85Nhz

[Suyang Zhang @Zhang_Suyang]

Two weeks left to apply for a PhD with us at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry

https://t.co/Ud5RRaw5Px

[Shih-Chieh (Jeff) Ti @JeffTiLab]

@Turfee Thanks!🙏

[Shih-Chieh (Jeff) Ti @JeffTiLab]

https://t.co/bTd7QeyQlG

The latest research article from the Ti Lab is finally out today in Nature Physics.

[Shih-Chieh (Jeff) Ti @JeffTiLab]

@GoryachevAndrew 🙏 thanks

[Shih-Chieh (Jeff) Ti @JeffTiLab]

which then determine the accessibility of the lumen to an luminal enzyme. This study opens new avenues to understanding the roles of microtubule building blocks in diverse biologically relevant mechano-environments.

[Shih-Chieh (Jeff) Ti @JeffTiLab]

regulate the accessibility of the confined microtubule lumen remain elusive.
In this paper, by employing optical tweezers, cryo-EM, computer modeling, and single-molecule fluorescence microscopy, we found that tubulin isotypes can regulate how microtubules respond to forces,

[Shekhar lab @sshekhr]

🎉🎉We’re on the cover of @NaturePhysics!!

Here is the original paper https://t.co/OXExuoqGFt

[NatureStructMolBiol @NatureSMB]

New online! The mechanochemical cycle of reactive full-length human dynein 1 https://t.co/Qa8FEAximv

[Shih-Chieh (Jeff) Ti @JeffTiLab]

@schul_kwon @emboreports Congratulations! 🎉

[Chul KWON @schul_kwon]

Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems | EMBO reports https://t.co/5s2KPR2S88 Our paper is out in @emboreports! 1/n

[DivIDE conference @DivIDE_2025]

We are delighted to announce that the 3rd DivIDE Conference will take place from 22–25 September 2025 with a fantastic lineup of speakers.

Registration opens soon - stay tuned and help us spread the word!

We are looking forward to meet many of you in Barcelona! ☀️

[Alushin_Lab @Alushin_Lab]

Excited that the peer-reviewed version of our fascin structure paper is now out in @NatureSMB. Thanks very much to the referees for their constructive feedback. https://t.co/awfbPda6TN

[Shih-Chieh (Jeff) Ti @JeffTiLab]

With help from @RuiZhangWUSTL we have successfully adopted Rui's protocol to achieve high-resolution cryo-EM 3D reconstruction of undecorated microtubules polymerized from recombinant tubulin. Please see the following user-friendly version of the workflow.
https://t.co/xlcB52FdkX

[Rui Zhang @RuiZhangWUSTL]

I want to take the opportunity to mention that I've written a slightly more user-friendly tutorial for the original microtubule seam-search protocol, together with other useful MT processing tricks.
https://t.co/Uzh7SuD4zR

[Cell Biology J-Club @cell_club]

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
https://t.co/JeqXv47iVB

[Shih-Chieh (Jeff) Ti @JeffTiLab]

@apatgir Thank you, Anupam😁

[Shih-Chieh (Jeff) Ti @JeffTiLab]

https://t.co/ntPpfOdxie
The latest research article from Ti Lab. We employed cryo-EM structural analysis, single-particle fluorescence microscopy, and recombinant tubulin to reveal how tubulin acetyltransferases modify the K40 residue inside the microtubule lumen. (1/N)