Alushin_Lab

Interested in cryoEM, cytoskeleton, and mechanosensation at the molecular level.

[Pilar Cossio @PilarCossio2]

1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion.
At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria?
New preprint: yes, straight from the raw particle images👇

[Pilar Cossio @PilarCossio2]

*Job alert*: Postdoc position at the Flatiron Institute to work on biophysical inference and cryo-EM. ❄️ 🔬Applications are welcome! https://t.co/oXkczVqSAm

[Lammerding Lab @LammerdingLab]

Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery?
Join our amazing faculty at the @weillinstitute at @Cornell University in Ithaca, New York.
https://t.co/UNkZ7kJdzL
Apply by Nov. 15!
Please share!

[D. Allan Drummond @dallandrummond]

We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Please share!
https://t.co/fdIE4cqSEX

[UC Berkeley MCB @berkeleyMCB]

MCB is hiring Assistant Professors across 3 divisions!:

🧪 BBS: https://t.co/HQiESqfMKh
🧬GGED: https://t.co/oqtRgs1d76
🦠IMM: https://t.co/NrgDHQpLFH

🗓️ Application Deadline: October 19, 2026

🔗 Click the links or scan the QR codes to learn more and apply

[Sue Biggins @SueBiggins]

Faculty opening in Basic Sciences @fredhutch! Egalitarian and supportive environment:

[Polly Fordyce @fordycelab]

Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)

[Martin Pacesa @MartinPacesa]

Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!

https://t.co/iqofxDnPGP

[Rockefeller University @RockefellerUniv]

How do cells convert mechanical information into a molecular process? The @Alushin_Lab has captured the first snapshot of a mechanical signaling complex in action, findings in @Nature that have implications for disorders related to myosin dysfunction.

🔗: https://t.co/sElRWanbAV

[Alushin_Lab @Alushin_Lab]

We thank the reviewers for their insightful comments which clarified many additional aspects of the paper beyond this key point. Congrats to co-first authors Ayala Carl, Matt Reynolds @mattabolic_rate , and Xiaoyu Sun @XiaoyuSun_LIM !

[Alushin_Lab @Alushin_Lab]

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature

https://t.co/gzEziWL8aB

[Alushin_Lab @Alushin_Lab]

After additional work, we believe that it is exclusively axial compression which produces supercoils. Compression can occur on a subset of filament segments even under conditions which globally produce tension, due to the stochastic mechanochemical cycles of uncoupled motors.

[Alushin_Lab @Alushin_Lab]

Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.

https://t.co/7GoQA85Nhz

[Alushin_Lab @Alushin_Lab]

Cytoskeleton enthusiasts: join us for the Cytoskeletal Motors GRC, July 12-17, 2026, in Portland Maine. Abstracts submitted by April 5 will be considered for short talks. Please apply!
https://t.co/yYaiLVpslC

[Rockefeller University @RockefellerUniv]

Scientists in the @Alushin_Lab figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview

🔗: https://t.co/aWncRDoKwv

[Nature Nanotechnology @NatureNano]

DNA nanodevice for analysis of force-activated protein extension and interactions.

A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins.

https://t.co/5jmdFDhENZ

[Klebanoff_Lab @KlebanoffLab]

🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici https://t.co/HJng8WvjOp

[Sarah C.P. Williams @sarahcpwilliams]

How do cells move, divide, and sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer and birth defects follow. @Alushin_Lab at @RockefellerUniv has developed new tools to probe this tiny, dynamic cell scaffolding.
https://t.co/NlBcWZQxN0

[Shih-Chieh (Jeff) Ti @JeffTiLab]

https://t.co/bTd7QeyQlG

The latest research article from the Ti Lab is finally out today in Nature Physics.