Alushin_Lab

Interested in cryoEM, cytoskeleton, and mechanosensation at the molecular level.

[Polly Fordyce @fordycelab]

Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)

[Martin Pacesa @MartinPacesa]

Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!

https://t.co/iqofxDnPGP

[Rockefeller University @RockefellerUniv]

How do cells convert mechanical information into a molecular process? The @Alushin_Lab has captured the first snapshot of a mechanical signaling complex in action, findings in @Nature that have implications for disorders related to myosin dysfunction.

🔗: https://t.co/sElRWanbAV

[Alushin_Lab @Alushin_Lab]

We thank the reviewers for their insightful comments which clarified many additional aspects of the paper beyond this key point. Congrats to co-first authors Ayala Carl, Matt Reynolds @mattabolic_rate , and Xiaoyu Sun @XiaoyuSun_LIM !

[Alushin_Lab @Alushin_Lab]

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature

https://t.co/gzEziWL8aB

[Alushin_Lab @Alushin_Lab]

After additional work, we believe that it is exclusively axial compression which produces supercoils. Compression can occur on a subset of filament segments even under conditions which globally produce tension, due to the stochastic mechanochemical cycles of uncoupled motors.

[Alushin_Lab @Alushin_Lab]

Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.

https://t.co/7GoQA85Nhz

[Alushin_Lab @Alushin_Lab]

Cytoskeleton enthusiasts: join us for the Cytoskeletal Motors GRC, July 12-17, 2026, in Portland Maine. Abstracts submitted by April 5 will be considered for short talks. Please apply!
https://t.co/yYaiLVpslC

[Rockefeller University @RockefellerUniv]

Scientists in the @Alushin_Lab figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview

🔗: https://t.co/aWncRDoKwv

[Nature Nanotechnology @NatureNano]

DNA nanodevice for analysis of force-activated protein extension and interactions.

A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins.

https://t.co/5jmdFDhENZ

[Klebanoff_Lab @KlebanoffLab]

🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici https://t.co/HJng8WvjOp

[Sarah C.P. Williams @sarahcpwilliams]

How do cells move, divide, and sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer and birth defects follow. @Alushin_Lab at @RockefellerUniv has developed new tools to probe this tiny, dynamic cell scaffolding.
https://t.co/NlBcWZQxN0

[Shih-Chieh (Jeff) Ti @JeffTiLab]

https://t.co/bTd7QeyQlG

The latest research article from the Ti Lab is finally out today in Nature Physics.

[Rockefeller University @RockefellerUniv]

Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.

Learn more below:
https://t.co/EVtKiEgNBf

[Jason Shepherd @JasonSynaptic]

Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab

https://t.co/tJSaWl7Ddk Trump Administration Puts New Chokehold on Billions in Health-Research

[Rockefeller University @RockefellerUniv]

Congratulations to Rockefeller’s #classof2025!!! #PhDone 🔬🎉🧬

[Edward T Eng @edward_eng]

Keith Hamilton from the @Alushin_Lab at Rockefeller University gave a deep dive into the first step of any structural biological workflow: sample preparation. Through test cases he showed the balance of what is easily doable versus preserving biology.

https://t.co/oVFTltoBYd

[Rockefeller University @RockefellerUniv]

New study in @ScienceAdvances: the Alushin lab shows how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex. Dysregulated afadin expression has been associated with carcinogenesis and cancer metastasis.https://t.co/GipzsP7JRr

[G.W. Gant Luxton, PhD 🏳️‍🌈🔬 @gwgl1979]

https://t.co/BBiG2N9Tkr Just published! We uncovered a molecular machine that connects the cell's two major structural networks revealing how cells accomplish precise internal reorganization - a process disrupted in diseases ranging from cancer to multiple sclerosis.