Trinity Cookis

PhD Candidate in the Nogales & Tjian/Darzacq groups @berkeleyMCB

[Trinity Cookis @trincookis]

Streptavidin grids have saved my PhD! Hope others find our protocol useful for their own samples!

[The Nogales Lab @NogalesLab]

We have received a lot of requests for help with making streptavidin affinity grids. We are happy to finally share our protocol for robust in-house fabrication of streptavidin affinity grids. Stay tuned for the accompanying video that is coming soon!
https://t.co/6IA1u7RRqg

[Armand @armandcognetta]

🚀🚀🚀

[Armand @armandcognetta]

Announcing General Proximity's $12M, 2x over-subscribed, pre-Series A round.

Medicine is in the dark ages. Our understanding of biology far exceeds our ability to perturb it therapeutically.

[Armand @armandcognetta]

There’s an enormous gap in the longevity field that almost no one is talking about.

No existing therapeutic modalities are capable of both systemic distribution and complex transformations.

Until we solve this, we won’t solve aging. 🧵

[The Nogales Lab @NogalesLab]

And our work on the activation of automethylated PRC2 by dimerization on chromatin has just been published in @MolecularCell. Congratulations @paulvictorsauer, Egor, @poepsel_lab and everyone else who contributed to this work! https://t.co/lhLFcJMNTI

[Trinity Cookis @trincookis]

@HoorayForZinder Also would recommend pepsin treatment O/N at 37 C - helped me unclog columns in the past

[Meagan Esbin @EsbinMeagan]

New study on #transcription regulation in human #placenta development - we find that the transcription factor #TFEB is required for the differentiation of a fusing cell type in the placenta (syncytiotrophoblasts) by controlling cell-cell fusion! https://t.co/Mj2tg2Dnkn 🧵

[Trinity Cookis @trincookis]

@zhadyra_yerkesh Thank you 😊

[Trinity Cookis @trincookis]

@ludicroce @NogalesLab Thank you Luciano!!

[Trinity Cookis @trincookis]

Happy to share the preprint of my first research paper from grad school on how the epigenetic silencer PRC2 is inhibited by histone modifications found at actively transcribed genes - check out the thread for more details!

[The Nogales Lab @NogalesLab]

Check out our latest work on PRC2 and its inhibition by active transcription histone posttranslational modifications led by @trincookis and work from twitterless undergraduate Alexandria Lydecker, @paulvictorsauer, and @vignesh_k757

https://t.co/9eSvsuJZda

[Trinity Cookis @trincookis]

What a privilege to work with you 🥰💪🏻🏅

[The Shaw Prize @ShawPrize]

“While science can be a challenge… All that pales in comparison to the thrill of the questions to be asked, of seeing them answered one day.”
Prof. Eva Nogales’ acceptance speech at 2023 #ShawPrize Award Presentation Ceremony.
https://t.co/4dHX3KNbX2
@NogalesLab @UCBerkeley

[Trinity Cookis @trincookis]

Happy to see our work on @biorxivpreprint on the activation of PRC2 through automethylation and dimerization! Great collaboration between @poepsel_lab, @paulvictorsauer, Egor Pavlenko, @NogalesLab, @KarissaScience, @EpiStrucStab

[The Nogales Lab @NogalesLab]

Check out this thread on our story on activation of PRC2 through automethylation and dimerization! Awesome team effort from @paulvictorsauer, Egor Pavlenko, @poepsel_lab, @trincookis @KarissaScience and the rest of our twitterless collaborators!

[Trinity Cookis @trincookis]

@AutophaZeke @biorxivpreprint @MinghaoChen10 Congrats Zeke! Awesome work!!

[Trinity Cookis @trincookis]

@danteshepherd I love this 😍

[Trinity Cookis @trincookis]

@LugerLab Congratulations!!!

[Trinity Cookis @trincookis]

I had a fantastic time attending my first #cshlmoet meeting - thanks to the organizers for putting together such a great program. Hope to see many of you again in 2025 for more fruitful discussions

[Trinity Cookis @trincookis]

@BioS_ME_Alsace @paulvictorsauer @BJ_Greber @IsraelF96135088 Thanks for sharing this! We will have to try that!

[Trinity Cookis @trincookis]

@IsraelF96135088 @TheBlanchardLab @cate_lab We have developed an optimized protocol in @NogalesLab together with Bob Glaeser to help users of streptavidin grids troubleshoot these types of issues. Happy to share the current version with anyone and we hope it will be out soon!

[Trinity Cookis @trincookis]

@DaireGannon @adrianbracken @GerardLBrien @tcddublin @tcdgenmicro Congratulation!!