Alex Hall Hickman

A post-grad researcher investigating the regulatory effects of G-quadruplex RNA on chromatin - Regulatory Genomics Group - UCL Cancer Institute

[Alex Hall Hickman @HallHickman]

Seems like highlighting molecular biology artefacts is a real trend for publications in 2024. Pleased to share @RegGenomics and I's work on the role of RNA in PRC2 recruitment @CellReports.

https://t.co/kJTyc2HNl4

[Aleksander Szczurek @AleksSzczurek]

In our new paper aided by single molecule imaging of RNA and transcription machinery we demonstrate how Polycomb Repressive Complex (PRC) represses transcription in live cells 🧵 https://t.co/mwrQN0ddF8 1/9

[Jeannie Lee @XistHarvard]

Re-analysis of CLAP data affirms PRC2 as an RNA binding protein and XIST RNA as a target.

We (YongWoo Lee, Roy Blum, Michael Rosenberg) examined the datasets of Guo et al. (PMID 38387462 - which reported that PRC2 is not an RBP) ...

https://t.co/8uoRIul9eP

[Cell Reports @CellReports]

Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipitation upon RNA degradation https://t.co/uSvvYwgfoh

[Chen Davidovich @DavidovichLab]

1/ Is RNA essential for PRC2 chromatin occupancy? Here we refute evidence that was previously used to support this idea.

Work by @evan_healy4 and @QiZhang85 from the @DavidovichLab, @MonashBDI, @EMBLAustralia.
https://t.co/Bef93jh6CA

[cricket.com.au @cricketcomau]

Every angle, every call – how the broadcasters celebrated Shamar Joseph and the West Indies' historic Gabba win #AUSvWI

[Adrian Bracken @adrianbracken]

Really looking forward to our next @irelandchrom webinar on Friday Nov 3rd at 4pm GMT / 5pm CET.

Richard Jenner @RegGenomics from @UCL will speak on ‘Understanding the effects of RNA on PRC2 and other chromatin regulators’. Please register at: https://t.co/6Gz1lgRzXE

[Alex Hall Hickman @HallHickman]

@historyinmemes Fireworks?

[Alex Hall Hickman @HallHickman]

@stojic_lovorka @RegGenomics @QMULepigenetics @BiochemSoc Thank you Lovorka. It was a pleasure to meet you this week!

[Richard Jenner @RegGenomics]

Congratulations to @HallHickman for winning best poster @BiochemSoc Transcription and Chromatin for his work on PRC2 and RNA!

[Alex Hall Hickman @HallHickman]

What a wonderful couple days of science 🧬

Huge thanks to @doctorconnor, @PradeepMadapura and Sonia Rocha for organising such an enjoyable symposium!

@BiochemSoc #BiochemEvent

[Pradeepa Madapura @PradeepMadapura]

Congratulations to @andreannafw and @HallHickman for winning @QMULepigenetics sponsored poster prizes at @BiochemSoc #biochemEvent on chromatin & transcription

[Faraz K Mardakheh @FKHM]

@RegGenomics @HallHickman Congratulations Richard and team! Really important work!

[Chen Davidovich @DavidovichLab]

You were told that RNA is essential for PRC2 chromatin occupancy.

We examined key evidence that previously supported this idea: it's an artefact.🧵

https://t.co/SSUeC2J5UK

[Alex Hall Hickman @HallHickman]

Excellent descriptive from Richard (@RegGenomics) detailing our work highlighting the loss of PRC2 chromatin occupancy under rChIP conditions as a symptom of non-specific chromatin precipitation. Please also check out the parallel study from @DavidovichLab @evan_healy4 @QiZhang85

[Richard Jenner @RegGenomics]

1/8 Our new pre-print from @HallHickman is out
https://t.co/UXSW9J0hbC

We report that the apparent RNA bridging between PRC2 and chromatin observed by Long et al 2020 using rChIP is an artefact of non-specific chromatin precipitation

Please alert colleagues using this method!🧵

[Alex Hall Hickman @HallHickman]

@matthewcobb Could it actually be "refund"?

[Alex Hall Hickman @HallHickman]

Lab Life: When your PhD (almost) falls apart https://t.co/kyG10OQD6s

[Ben Nacev, MD PhD @BenNacev]

Really great mechanistic work to understand PRC2 dysregulation by a common fusion protein in endometrial stromal #sarcoma. Congrats @Manuel_TavaresC . We need more like this!

JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell... https://t.co/JIqeQdi4Km

[Richard Jenner @RegGenomics]

Just a reminder there is one more week to apply to the #postdoc position available in my lab to work on the effects of nascent RNA on chromatin at @uclcancer

Please see: https://t.co/Qj2xvaX5ZW