Chen Davidovich

Gene repression, RNA and all chromatin things. @MonashUni @EMBLAustralia

[Chen Davidovich @DavidovichLab]

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. https://t.co/JaFmo1EoNw

[Cell @CellCellPress]

In the latest issue! RNA modifications in gene regulation: Functions and pathways https://t.co/XzBzJxxhhn

[Teif Lab @TeifLab]

Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: https://t.co/Z1TgEYxBH8

A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy!
#nucleosomics #nucleosome #chromatin #cfDNA

[Molecular Cell @MolecularCell]

Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains https://t.co/do6RVK8jgg

[Chen Davidovich @DavidovichLab]

6/ A fantastic collaboration between the
@DavidovichLab and the @Eddy_McGlinn labs, led by a brilliant PhD student, @SamAgius0, who is now looking for a postdoc position!

[Chen Davidovich @DavidovichLab]

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. https://t.co/JaFmo1EoNw

[Chen Davidovich @DavidovichLab]

5/ We propose that H3K27me3 mimicry has repeatedly emerged during evolution as a mechanism to antagonise PRC2 and restrict the spread of Polycomb domains.

[Gantier Lab @GantierLab]

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > https://t.co/Kh8y8C8pMw

[Chen Davidovich @DavidovichLab]

H3K79me2/3 is sufficient to antagonise PRC1 https://t.co/junFSOvyjO

[Jun Cheng @s6juncheng]

AlphaGenome paper and models are out today! https://t.co/WHejipHfu7. We have seen great community engagement since we released the API. We hope to open more use cases with the model weights! https://t.co/TUfKPeOYyY

We updated the supplementary note with some very interesting case studies. I encourage everyone using AlphaGenome for non-coding variant interpretation to read it.

It was a huge team effort, I’m very proud of all of our co-authors @googledeepmind!

[Eduardo Eyras @EduEyras]

Excited to share our latest preprint: "SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications" https://t.co/KceYfGMCho
Led by @StefanProdic et al. #RNA #Epitranscriptomics #Nanopore
1/6

[Chen Davidovich @DavidovichLab]

2/ Done in collaboration with the lab of @adrianbracken, who wrote a great 🧵 explaining the work. https://t.co/b6U3TERtYd

[Adrian Bracken @adrianbracken]

1/ 🚀 AEBP2 isn’t what we thought.

You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.

Excited to share our new paper https://t.co/TkvcVM26xi

A thread 🧵

[Chen Davidovich @DavidovichLab]

1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite:
The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. https://t.co/WpJ8EETV1p

[Adrian Bracken @adrianbracken]

1/ 🚀 AEBP2 isn’t what we thought.

You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.

Excited to share our new paper https://t.co/TkvcVM26xi

A thread 🧵

[James Nolan @JMNolan89]

🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on https://t.co/XrvHsiwtZh. Here's a thread with our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma

[Mathias L. Nielsen @_MathiasLN]

Thrilled to see this out in @MolecularCell
Led by the fantastic @sulteavn 👏

Revealing how PRC2 accessory proteins polymerise and shape gene regulation 🧬🌱

https://t.co/zr6pwFKA9b

[Eric Joyce @ericjoycelab]

🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
https://t.co/KGTUAZqHyS

[Qi Zhang @QiZhang85]

🚨 We’re hiring!
Join @SAiGENCI in Adelaide as a Structural Biologist in my lab 🧬🔬
Use cryo-EM & biochemistry to unravel chromatin-associated complexes.
💰 $102k–$135k
📍 World-class facilities + Titan Krios access
https://t.co/7z6ImKcLQ4 #cryoEM #structuralbiology #chromatin