Hannah Augustijn

PhD candidate at @LeidenBiology and @WUR | Computational biologist interested in bacterial regulation and natural products 🦠

[Hannah Augustijn @HannahAugustijn]

Of course many thanks go out to my supervisors, @marnixmedema & @GillesvanWezel, as well as @ZachReitzPhD, Greg @Challis_Group, and all others involved in this project 🙌

[Hannah Augustijn @HannahAugustijn]

To test our method, we focused on DmdR1, which regulates iron-starvation response and has a strong relationship with siderophore BGCs. When we used TFBSs and co-expression patterns to find the DmdR1 regulon, we discovered an unknown locus seemingly linked to desferrioxamines

[Hannah Augustijn @HannahAugustijn]

This shows that even in a well-studied model organism like Streptomyces coelicolor and a well-known pathway like desferrioxamines, we could still discover something new by considering regulation‼️

[Hannah Augustijn @HannahAugustijn]

To infer BGC function using regulation, we focused on experimentally validated transcription factor binding sites (TFBSs) of S. coelicolor. You can explore this collection of TFBSs in our LogoMotif database 🚂 https://t.co/P9Nc4Dg9LF

[Hannah Augustijn @HannahAugustijn]

I’m so proud to present a key story of my PhD project! 🦠🧫Together with @ZachReitzPhD, we developed a regulation-based strategy to predict gene cluster function and used it to discover a new BGC in Streptomyces coelicolor.
Check out our preprint here: https://t.co/avxGEeOnsX

[Gilles van Wezel 💙💛 @GillesvanWezel]

geweldig verhaal van onze @HannahAugustijn bij @WUR Dies Natalis over de potentie van bacteriën als bron van nieuwe medicijnen. @marnixmedema.
@ERC_Research
@WURplant @LeidenBiology

[Marnix Medema @marnixmedema]

At the @WUR Dies Natalis, @HannahAugustijn just gave a fantastic short research talk about how to unlock the chemical potential of the microbiome by understanding the way their biosynthetic gene clusters are regulated. @WURplant @LeidenBiology @GillesvanWezel

[Hannah Augustijn @HannahAugustijn]

Missing your favourite regulator in our collection? Reach out! We're more than happy to expand our database with your input 🤝

[Hannah Augustijn @HannahAugustijn]

Excited to share our new preprint on LogoMotif! 🚂 We've created a database dedicated to transcription factor binding sites of Actinobacteria for regulatory network exploration 🧬🔍 Thanks to @marnixmedema @GillesvanWezel and all others! Read more at: https://t.co/TbHncFGiW6

[Hannah Augustijn @HannahAugustijn]

Using antiSMASH to look at BGCs? LogoMotif serves as foundation for regulatory predictions in antiSMASH v7 via the TFBS Finder module.

[Gilles van Wezel 💙💛 @GillesvanWezel]

our paper on siberian Mammoth Actinomycetes and their natural products is out! Great work by @BergeijkDoris @HannahAugustijn @marnixmedema @driesbudding @SpainkHerman
and colleagues
https://t.co/0UuMbDlj5B

[Fabrizio Alberti @AlbertiFabrizio]

And that’s a wrap! Thank you to everyone who attended the #CBNP16 at @uniofwarwick, @UKRI_News and @RSC_CBBG for funding, @pnleao and @ZachReitzPhD for fantastic closing lectures, and all other speakers and poster presenters for their wonderful contribution!

[Zach Reitz @ZachReitzPhD]

@MunroPassmore @Jenner_Lab @Challis_Group @HannahAugustijn @GillesvanWezel @marnixmedema Check out the LogoMotif regulator database as well! @HannahAugustijn #CBNP16

[Wendy Tigani @WendyTigani]

I am a speaker at @PGPRworkshop 2023! Beautiful, sunny Toulouse and really nice crowd of plant-microbes interactions enthusiast experts... what else? 😊

[Hannah Augustijn @HannahAugustijn]

I feel honored to receive the first place poster prize at #NWOlife for a poster about my PhD project on bacterial regulation 🦠🧬 Huge thanks to everyone involved in the different projects and of course my supervisors @marnixmedema and @GillesvanWezel

[Wendy Tigani @WendyTigani]

Thanks to #NWOlife for the chance to share my work!

[Kai Blin @kaiblin]

We've released version 7.0.0 of antiSMASH.
This version adds 10 BGC types, RiPP precursor comparisons, transcription factor binding site preds, and new viz. It also updates A domain substrate predictions and cluster comparison DBs. See https://t.co/3hDHkAni3m for more details