Hansen Lab

Mechanisms of Mechanosensation, Anesthesia, and Inflammation/Dementia | Spatial Biophysics

[Eric Topol @EricTopol]

The suppressed report that concluded there is no protective or safe level of alcohol consumption, now published. It was commissioned by US Congress
Report https://t.co/XmmsSo9q3q
Editorial https://t.co/8NuqBwkugM
"Despite the study’s adherence to its mandate, its findings were sidelined.”

[Hansen Lab @HansenLab2]

@FCademartiri What if the chronic inflammation in all the tissue is the problem? Then all tissues are involved.

[Hansen Lab @HansenLab2]

@JasonSynaptic @Canxuki @grok how does the NIH budget compare this year to last year?

[Hansen Lab @HansenLab2]

The CIMR summer program is for undergraduates and masters students thinking about med school or a PHD?

[Hansen Lab @HansenLab2]

The Chinese Institutes for Medical Research (CIMR) is hosting an international summer program in biomedical research June 15th to July 31 2026. Beijing China.

Pick your track either clinical or basic research.

Participants receive travel (up to $2000 USD), food, and housing.

Work with top researchers from around the world, all in English.

For more information:
https://t.co/9bIWzwNuHv

[Hansen Lab @HansenLab2]

@MushtaqBilalPhD This is what happens when congress can't agree on a budget. They need 60 votes and they only have 55. US scientists need to encourage their
Congressman to vote yes on a budget.

[Hansen Lab @HansenLab2]

I never vilified cholesterol. I study cholesterol, I think its one of the most important molecules in the body. It drives neuronal excitability, a proper heart beat, good emotions, bad emotions, and yes inflammation. Cholesterol is central to an inflammatory response. And inflammation is good until it becomes chronic. So again I'm not vilifying it. But people need to understand that cholesterol is a central regulator of inflammation. And too little or too much in the diet can be bad. I'm happy to go through the data, its very clear.

[Hansen Lab @HansenLab2]

@EricTopol Intersting

[Eric Topol @EricTopol]

A simple ingestible pill innovation for monitoring inflammation of the gut
https://t.co/bEIKuoyBcq

[Hansen Lab @HansenLab2]

@ValerieAnne1970 A focus on blood cholesterol has been a hindrance to the science. The blood is simply a transport system. Overtime it says little about what the actual levels of cholesterol are in the plasma membrane of cells, where it actually matters.

[Hansen Lab @HansenLab2]

I respectfully disagree. At a molecule level an inflammatory response is not possible without cholesterol and saturated lipids. The cholesterol activates the hydrolysis and release of inflammatory cytokines by clustering them with their hydrolytic enzymes. This review explains the process. https://t.co/lAof2UWmaR

[Hansen Lab @HansenLab2]

@EstebanDL Depende cuando empieza la inflamcion cronica. La function de colesterol es protejer la membrana. Pero si siga hasta que no hay moleculas disruptivas, alli empieza las problemas.

[Hansen Lab @HansenLab2]

Mechanisms of General Anesthesia | Annual Reviews - https://t.co/qUhBaKGVy1. Newly incorporated membrane mediated anesthesia...

[Hansen Lab @HansenLab2]

I think positional activation is more powerful than allosteric activation alone. A change in position allows for the integration of many signals only after activation.

For example, if the signal for delay is in one compartment and the enhanced activation is in the other compartment, then when the neurotransmitter causes a shift it can get both outcomes. Delaying activation and enhancing activation with a single allosteric activator is more difficult to evolve. Its easy if the channel changes position.

[Hansen Lab @HansenLab2]

Our most recent study shows how brain cholesterol from astrocytes causes hyper-excitability in Alzheimer's neurons this is a new paradigm in excitability. Congrats Zixuan its great work. https://t.co/cfvIvu4VTB

[Hansen Lab @HansenLab2]

Los niveles de colesterol en el tejido son lo que importa, no lo que se transporta. Si los órganos del cuerpo están llenos de colesterol y los niveles en sangre disminuyen, no indica que la persona esté sana. Y el colesterol es un lípido señalizador. Y el colesterol puede estar alto en la sangre y bajo en el tejido. Por ejemplo, las personas sanas a veces tienen la capacidad de cargar y descargar grandes cantidades de colesterol de sus tejidos cuando están descargando el colesterol, los niveles en la sangre suben. Esto no se debe a que no estén sanos, es lo contrario, la capacidad de mover grandes cantidades de colesterol puede indicar que alguien está muy sano. Es absurdo pensar que podemos medir el colesterol en las proteínas séricas y creer que sabemos lo que está sucediendo en el corazón o las arterias. El colesterol puede acumularse durante décadas y no tener nada que ver con el colesterol en el suero.

[Hansen Lab @HansenLab2]

@EstebanDL Podemos comenzar midiendo el colesterol en el tejido, no en la sangre.