Haopeng Wang

Associate Professor at ShanghaiTech University & Adjunct Faculty Member at Institute for Immunology Tsinghua. Expertise in designing CAR-T, TCR-T, and CAR-Treg.

[Haopeng Wang @HaopengWang_Lab]

Thrilled to share our latest #Cell paper revealing how the immune checkpoint LAG3 switches "OFF→ON"! Huge thanks to our incredible team @ShanghaiTechUni , @ChenqiXuSH , @Vignali_Lab , @BeOneMedicines
#Cancer #Immunology #CancerTreatment
https://t.co/XkWzFI9KIy

[Cancer Cell @Cancer_Cell]

Online Now: T cell extracellular vesicles go nuclear to turn cold tumors hot https://t.co/lpHj0GZIpx

[Haopeng Wang @HaopengWang_Lab]

Excited to share my Preview of David Lyden's elegant work in @Cancer_Cell:
EVs deliver T cell genomic DNA into DCs & tumor cells. Combined with PD-1 blockade, cold tumors turn hot: A cell-free immunotherapy blueprint🔥
#CancerImmunotherapy #Immunology
https://t.co/RNkqFQszE5

[Cell @CellCellPress]

In the latest issue! Cell death in cancer https://t.co/T7Xt5vECwK

[Yoshihisa Okazaki @XX62]

『Coordinated IL-2 and TGF-β Signaling via a Novel Fusion Protein Selectively Expands and Activates Regulatory T Cells』
bioRxiv　March 11, 2026.
CUE-401はIL-2とTGF-β3を組み合わせた二機能性バイオ医薬で、Tregを選択的誘導・増殖・安定化させ自己免疫反応を抑え動物モデルで免疫寛容達成

[Haopeng Wang @HaopengWang_Lab]

Our preview on the FIRST AAV-based in vivo CAR-T：

No leukapheresis. No ex vivo manufacturing. Just inject.

AI-engineered AAV selectively targets CD62L⁺ naive T cells → reverses SLE in humanized models

📖 https://t.co/t58tzU5dqT

#InVivoCART #AAV #GeneTherapy #SLE

[Cell @CellCellPress]

Now online! Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation https://t.co/S1EomHf58q

[Haopeng Wang @HaopengWang_Lab]

❌ CAR-T exhausted before seeing the tumor — a Tonic Signaling Issue

✅ Charge optimization → Tscm preserved, durable tumor control in HNSCC.

The lesson: CAR biophysics = T cell fate

Proud of Dr. Chen, now independent PI
@FudanUniversity
https://t.co/Pqz0mEBZRL

[Haopeng Wang @HaopengWang_Lab]

𝗥𝗲𝘁𝗵𝗶𝗻𝗸𝗶𝗻𝗴 𝗖𝗔𝗥-𝗧 𝗳𝗼𝗿 𝗔𝘂𝘁𝗼𝗶𝗺𝗺𝘂𝗻𝗲 𝗗𝗶𝘀𝗲𝗮𝘀𝗲: Our new study challenges the "transient depletion" paradigm: Genetic lupus needs persistent, not transient, CAR-T therapy. @JMCellBiol https://t.co/dCZcKh2WHb

[SunneyXie @XieSunney]

Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell.
https://t.co/o2s0bdQ12F

[Haopeng Wang @HaopengWang_Lab]

@XieSunney Big Congrats, Sunny! What a Incredible work! 🧬

[Haopeng Wang @HaopengWang_Lab]

What a beautiful study from Dr. Bernard Malissen! A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo https://t.co/3f2LipLb6u

[Cell @CellCellPress]

In the latest issue! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs https://t.co/pk5Sz3nBPN

[SunneyXie @XieSunney]

Congrats to Xinyao and Xie Chen! In eukaryotes, multiple transcription factors bind cooperatively to a regulatory region on genomic DNA to control gene expression. In this paper (https://t.co/e68YFhc0UT), we present an experimental metric for quantifying such cooperativity.

[Haopeng Wang @HaopengWang_Lab]

Understanding LAG3 immune checkpoint function https://t.co/fipkMZpjEl

[Haopeng Wang @HaopengWang_Lab]

Just out in @CellCellPress!
Prof. Kai W. Wucherpfennig previews our study: “Unlocking LAG3: Ubiquitin’s Unexpected Role.”
LAG3's non-degradative poly-Ub by Cbl ligases flips this checkpoint ON and marks TILs that respond to PD-1/LAG3 combo therapy.

https://t.co/uQZ48yfE8E

[BioCentury @BioCentury]

Science Spotlight: New insight into LAG3's checkpoint function, a blood-based T cell assay for Type I diabetes, a degrader using a new E3 ligase, and paper from newcos. BioCentury's roundup of translational innovations https://t.co/oUqPJeeA7Y

[Lasker Foundation @LaskerFDN]

Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function. @HaopengWang_Lab found ubiquitination of LAG3 promotes its inhibitory function rather than its degradation, and is required for suppression of antitumor immunity in vivo. https://t.co/ukgZOWvGz9

[Haopeng Wang @HaopengWang_Lab]

Just published a review on CAR-T tonic signaling and introduced the "Peak Theory"—finding the optimal signaling level to overcome T-cell exhaustion and enhance efficacy in cancer, autoimmune diseases, and more.

https://t.co/hVLkHFvS1b

#Immunotherapy #CART

[Haopeng Wang @HaopengWang_Lab]

D-STAR: The Gemini Guardians redefining dual-targeting of immune cell ... https://t.co/2ljwuzmPrX

[Cell @CellCellPress]

Now online! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs https://t.co/QKPBxSjoAc