Frederique J. Hart de Ruyter, MD

PhD candidate Alzheimer Center Amsterdam | Studying the eye as a source for biomarkers in Alzheimer's disease

Author of article:

[NU.nl @NUnl]

Netvlies kan mogelijk helpen dementie in een vroeg stadium te signaleren
https://t.co/KCRCLFdXxh

[RTL Nieuws @RTLnieuws]

Dementie opsporen via oogscan is volgens onderzoekers stap dichterbij https://t.co/1arhYf5CgG

[Neurology Journal @GreenJournal]

This study found people with #Parkinson disease have reduced thickness of the INL & GCIPL of the retina. Involvement of these layers several years before clinical presentation highlight a potential role for retinal imaging for at-risk stratification of PD: https://t.co/TNXm2ILPx0

[Anke Dijkstra, PhD @DrAnkeDijkstra]

🚨TDP-43 pathology in the retina 👁; could this be a potential biomarker for FTD?
#neuroscience #retina #ftd #neuropath #neurodegeneration #biomarker
@JeroenHoozemans @HartRuyter
@JurredenHaan @AlzheimerAms @alzheimernl https://t.co/HngcULH1y6

[Michael Okun @MichaelOkun]

Do you know the story these '99' eyes told us about parkinsonism? Can you believe these scientists collected '99' post-mortem eyes which revealed something interesting with α-synuclein. We think about dopamine retinal amacrine cells and thinning of the retina however check out these results.
'Multiple retinal and optic nerve cross-sections were immunostained with anti-α-synuclein antibodies.' α-Synuclein seen as Lewy neurites in retina and oligodendroglial cytoplasmic inclusions in the optic nerve.
100% of multiple system atrophy cases, optic nerve had oligodendroglial cytoplasmic inclusions, and retinal Lewy neurites were absent in these cases. https://t.co/xPB30pxuzj

[VJDementia @VJDementia]

Eyes are windows to the soul... or at least to disease pathology in the CNS👀

We heard from Dr @HartRuyter about p-tau & microglia in the retina of patients with AD & the connection between retinal & brain pathology

#AAIC23 #NeuroTwitter #Dementia

[Baayla DC Boon @BaaylaB]

Moving from traditional #neuropath markers to Neuroinflammation in the retina presented by @HartRuyter 🤩, suggesting that the 👁️ can function as a window to the 🧠 for active disease 👏🏻 #AAIC23 @JeroenHoozemans

[Alzheimercentrum Amsterdam (inactief) @AlzheimerAms]

Frederique Hart de Ruyter, promovenda bij @AlzheimerAms, onderzoekt schadelijke eiwitten in het oog. Op lange termijn zou dit een eerste stap kunnen zijn naar het gebruiken van oogscans om #dementie aan te tonen. Lees haar interview met @alzheimernl 👇 https://t.co/PO1Ekv0nYA

[Frederique J. Hart de Ruyter, MD @HartRuyter]

Increased #pTau in the #retina corresponds with pTau in the brain. Our results support the development of in-vivo retinal imaging techniques for neurodegenerative diseases👁️🧠 https://t.co/vWsIdWEZFI

[Baayla DC Boon @BaaylaB]

Go check out this beautiful #neuropath study in which we expended the tau spectrum in the retina. Especially beautiful work from @HartRuyter , Tjado en @JeroenHoozemans 🎉

[Frederique J. Hart de Ruyter, MD @HartRuyter]

Read our latest #research "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies", published with @SpringerNature in Acta Neuropathologica. https://t.co/vWsIdWErQa

[RikOssenkoppele @RikOssenkoppele]

This is an important message to all of us working in the biomarker field.

[RikOssenkoppele @RikOssenkoppele]

Great plenary by Thomas Beach about neuropathology in the era of biomarkers. #AAIC22

(And I got lucky capturing the transitioning of slides)

[Baayla DC Boon @BaaylaB]

Goosebumps when these two wonderful people invited us to Amsterdam for next year’s AAIC (🤞🏻🤞🏻🤞🏻). Can’t wait for everyone to experience this most beautiful city!! 🧡 @PhilipAlz @AlzheimerAms #ENDALZ #AAIC2022

[Frederique J. Hart de Ruyter, MD @HartRuyter]

@AlzheimerAms represent at @alzassociation international conference #AAIC22 🧠💜  #amsterdamumc

[Frederique J. Hart de Ruyter, MD @HartRuyter]

Presenting our work from @amsterdamumc @AlzheimerAms Alzheimer Center Amsterdam on p-tau in the retina at @alzassociation international conference San Diego #ptau #retina #AAIC22 #AlzheimersDisease

[Jurre Den Haan @JurredenHaan]

Super proud of @HartRuyter presenting at the ADPD conference! Retinal tau is present in AD and other tauopathies and might be a potential biomarker! @adpdnet #ADPD2022

[Jurre Den Haan @JurredenHaan]

Off to Barcelona for @adpdnet! Finally an in person scientific meeting again :). Looking forward to two (!) oral presentations on post mortem retinas from our eye and brain team in AD/FTD cases by @HartRuyter and @DrAnkeDijkstra respectively.

@AlzheimerAms
@alzheimernl

[Frederique J. Hart de Ruyter, MD @HartRuyter]

Looking foward to @adpdnet 2022 in Barcelona where I will be presenting our work studying retinal tau pathology in a cohort of neurodegenerative diseases👁️🧠

[Dr. Glaucomflecken @DGlaucomflecken]

Conference Q&A

[Jurre Den Haan @JurredenHaan]

Our paper is out now @medrxivpreprint :
'No proof for retinal amyloid after oral curcumin in amyloid confirmed AD cases'
A result of 7 year team work, thanks to all involved!

https://t.co/bHmLb5QFgb

@HartRuyter @PhilipAlz @CharlotteTeuni1 @JeroenHoozemans
#EyeAsMarkerPIA