John Frase

[Camus @newstart_2024]

Chris Williamson reading Mark Manson’s “10 years of therapy in 1 minute” is gold.

Here’s the condensed wisdom:

1. No one is coming to save you. You’re responsible for your life — even the parts that aren’t your fault.

2. Strong boundaries beat weak ones every time.

3. Most problems don’t get “fixed.” You just learn to live well with them.

4. Your mind lies constantly. Tell it to shut the fuck up.

5. Stop trying to convince people to like you. The right ones won’t need convincing.

6. Sometimes the best move is letting a dream die.

7. Only a few people will truly matter long-term. Keep them close.

Mark’s reaction? “Why isn’t this taught in schools?”

Which of these hits you the hardest right now?

[SuperiorUSMNT @EinSchwarzwelt]

So many good takeaways and points from this Poch quote on American soccer development.

[Hunter Biden @HunterBiden]

To everyone so eager to cancel someone for a tattoo they got at age 22, a drunk text, a selfie they took in the middle of a mental health crisis:

Show us your laptop.
Show us your iCloud.
Open your entire digital life to your worst enemy. No context. No filter. No explanation.

You won’t.

You won’t because you know what I know. Any one of us, frozen at our worst moment, photographed in our lowest hour, looks like a monster. Looks like a stranger. Looks like someone who deserves to be cast out.

That is not who we are.

My mom and baby sister were killed in a car accident when I was just a kid. Cancer took my brother Beau, my best friend and my rock. I battled alcoholism. I battled addiction. I chose the coward’s way out more times than I can count.

For years I believed the defining chapters of my life were written by tragedy, loss, and shame.

I no longer believe that.

Pain can shape us. Loss can humble us. Failures can leave scars that never fully fade. But none of them have the authority to define us.

And it sure as hell ain’t the critic that counts.

That authority belongs to us alone-the person in the arena.

Every setback presents a choice. Play the victim, or cut the bullshit and take ownership for who we become next.

Life does not determine our character. It reveals it.

Again and again we are asked the same question. When shit happens, what next?

We are not defined by what happened to us. We are not defined by the worst photo, the worst text, the worst tattoo, the worst night. We are defined by the person we choose to become. And by the courage to choose that person, every single day.

So before you reach for the gavel - show us your laptop.

You won’t.

The whole world saw mine. And I am still here. Still becoming. Still choosing. Still standing.

That is the only definition that matters.

[Massimo @Rainmaker1973]

This is incredible

[📹 Thomas Deininger / tdeininger]

[John Frase @Hawgellujah]

@andruyeung I'm 50 and legit more fit than 99% of these people (six pack abs and so forth) and I drink a strong old fashioned every night

[John Frase @Hawgellujah]

@ramez As an early and avid reader of the Song of Ice and Fire books, I've long resigned myself to the inevitability that the books will never be completed. Maaaaaybe Winds of Winter but that's it. I refuse to watch the shows past the books

[prinz @deredleritt3r]

Demis Hassabis:

"Ten years from now, I think we will realize that we were standing in the foothills of the singularity now... I believe that we're only a few years away from [AGI], maybe 2030 plus or minus a year...

I think [AGI] will be an enormous transformative technology, it's going to effectively be a new human era...

We can feel this year, I would say, even though I've been working towards this for 30 years, I think this year with the way the agents are working and tool use, it started to become really useful, still early days of it, but genuinely useful in people's workflows...

And it's not any one thing, it's several different technologies, several use cases, several things that I thought were maybe a bit further out, turned out to be now, that are coming together that make me feel that in aggregate.

I think society needs to hear that because we don't have long to prepare for what that means."

[O’Shea Jackson Jr @OsheaJacksonJr]

I saw it. Now you have to see it. His name is Samuel. And he…is a king.

[College Baseball News @CollegeBSBNews]

On April 3rd, Milwaukee was 5-22 and one of the worst teams in the country.

Some of their losses:

Run-ruled 21-7 by LSU
Run-ruled 20-3 by Duke
Run-ruled 14-4 by Minnesota
Run-ruled 12-2 by SEMO
Run-ruled 17-1 by Purdue
Run-ruled 14-1 by NKU
Run-ruled 13-2 by Wright State
Run-ruled 16-2 by Notre Dame
Run-ruled 14-4 by UNLV

They finished the regular season 22-31, but won the Horizon League tournament and earned an autobid to the NCAA tournament.

Milwaukee beat #4 Auburn 13-8, beat UCF 13-6, and is now in a regional final, one win away from going to supers.

College Baseball.

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[John Frase @Hawgellujah]

@SarahLongwell25 It's because he's such an effective communicator. In electoral politics, that's the single biggest key. He's the best comminicator since Obama. Talarico is super talented in that area as well but he needs some time in the oven before the big stage. Similar to Pete's trajectory

[John Frase @Hawgellujah]

@TorresOnTheHogs Looks like a team with a lot of great players but is not a great team

[Pope Leo XIV @Pontifex]

Artificial intelligences do not undergo experiences, do not possess a body, do not feel joy or pain, do not mature through relationships, and do not know from within what love, work, friendship or responsibility mean. Nor do they have a moral conscience, since they do not judge good and evil, grasp the ultimate meaning of situations, or bear responsibility for consequences. They may imitate or even simulate, but they do not understand what they produce, for they lack the affective, relational, and spiritual perspective through which human beings grow in wisdom. #MagnificaHumanitas

[Avi Roy @agingroy]

Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months.

Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions.

BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible.

Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.

[Eric Levitz @EricLevitz]

Trump could have presided over a very strong economy. All he had to do was...nothing: Inflation was trending downward, the AI boom was raising growth.

Instead, he engineered a global trade war and energy shock, while shrinking America's labor force. https://t.co/JvvlsQ83R8

[John Frase @Hawgellujah]

@Aella_Girl Same. Wanted to invest in Amazon and Google in 2008 but was convinced the "smart" investors find undervalued stocks. I was thinking long term. They were not. Oh well

[Crazy Moments @Crazymoments01]

She waited 9 months for this moment

[Hollywood Horror Museum @horrormuseum]

So stupid but it made us laugh

[Rebecca Aguilar (on Blue Sky & LinkedIn) @RebeccaAguilar]

Everyone COPY this video, share it far and wide. Paramount Skydance billionaire baby David Ellison can’t handle that Stephen Colbert is getting millions of views . @Youtube we will cancel our subscription as we did when we dumped @paramountplus.

[𝗧𝗶𝗺𝗲𝗹𝗲𝘀𝘀 𝗠𝘂𝘀𝗶𝗰 ✨🎵 @Hoang_HQ]

One of the most beautiful versions of Hotel California I have ever heard. It's magical.😱
🎶The Eagles - Hotel California - | Moyun