Mark Hedglin

Assistant Professor of Chemistry studying the regulation of DNA Damage Tolerance and its implication in human disease and chemoresistance.

[Mark Hedglin @Hedglin_Lab]

WE ARE…HIRING POSTDOCS

The Hedglin Lab @ PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Details of the position & how to apply are below. Please spread the word & DM with any ?’s

https://t.co/3Dee1dBH0g

[Mark Hedglin @Hedglin_Lab]

Also, an honest & sincere thank you to the handling editor & all reviewers for their constructive criticisms & feedback that helped in bringing the best version of this story to life.

[Mark Hedglin @Hedglin_Lab]

Excited to see this out @nar_open. 2nd of two 1st author publications on this topic by Dr. Rachel Dannenberg,
a recent PhD graduate @psu_chemistry @PSUScience. Rachel started this project in 2020 & took us all for a wild ride. She will be greatly missed.
https://t.co/vyt7UQdFpP

[Environmental Mutagenesis and Genomics Society @EMGSUS]

MEET THE SPEAKERS! Our invited speakers for Symposium 10 of #EMGS2025, "Environmental toxicants and Genome Integrity: The regulation and roles of DNA polymerases," will include Drs. Vanesa Gottifredi, Penny J. Beuning, and Robert L. Eoff.🧬

[Mark Hedglin @Hedglin_Lab]

Research mentors, “unofficial” mentors within the PSU & greater scientific communities, colleagues, former lab mates. Thank you all so much.

[Mark Hedglin @Hedglin_Lab]

https://t.co/GmdgmGARyD
It’s official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories within such an amazing community.

[Mark Hedglin @Hedglin_Lab]

This is a credit to all past & present lab members whose hard work, dedication, & scientific intrigue made this dream a reality. Also, a credit to SO many along the way (too many to mention by name) that provided unwavering support, motivation, & inspiration.

[Mark Hedglin @Hedglin_Lab]

@maria_spies @PietroPichierri Congrats Maria and all authors. So excited to see this finally out. It’s a game changer.

[Mark Hedglin @Hedglin_Lab]

Major implications for interplay between human DNA damage tolerance pathways. A culmination of the continuous efforts of lead author Jessica Norris, recent Chemistry PhD graduate @psu_chemistry & another great collaboration with the Edwin Antony lab.

[Mark Hedglin @Hedglin_Lab]

New pre-print from our lab @psu_chemistry @PSUScience. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments @ stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading.
https://t.co/WojYlRqydI

[Mark Hedglin @Hedglin_Lab]

Looking forward to 2027!!

[Mark Hedglin @Hedglin_Lab]

That’s a wrap to Mammalian DNA Repair @GordonConf. MUCH thanks & appreciation to @RogerRogergr & @hildaApickett for organizing an exceptional meeting. Thankful 4 the opportunity to give a talk on our research @psu_chemistry @PSUScience & 4 the insightful & constructive feedback.

[Mark Hedglin @Hedglin_Lab]

Excited & en route to attend Mammalian DNA Repair @GordonConf . Looking forward to catching up with old friends, making new connections, learning new science & presenting our recent advances from @psu_chemistry @PSUScience

[Mark Hedglin @Hedglin_Lab]

Had a phenomenal time visiting the Dept of Med Chem at the U of Kansas. Grateful for the opportunity to present some of our research @psu_chemistry @PSUScience. Many thanks to @LukeErber for the invite & the dept for sharing their exciting science & for the hospitality.

[Mark Hedglin @Hedglin_Lab]

@WApatrickmao Thanks Peng, appreciate it.

[Mark Hedglin @Hedglin_Lab]

Check out our latest pre-print, a follow-up to our 2022 NAR study. Now we have characterized encounters of human DNA polymerase delta holoenzymes with 10 biologically-significant & structurally diverse DNA lesions. Follow 🧵 for key findings & implications
https://t.co/CYdbGphPHN

[Mark Hedglin @Hedglin_Lab]

polymerase delta holoenzymes promotes their progression at certain lesions by providing multiple attempts at one or more dNTP incorporation steps involved in lesion bypass.

This work was led by 5th year @psu_chemistry PhD student Rachel Dannenberg @PSUScience

[Mark Hedglin @Hedglin_Lab]

by pol delta-independent & -dependent mechanisms.

5. Proofreading by human pol delta holoenzymes does not deter their progression at any of the 10 lesions analyzed. Rather it significantly promotes progression at 7 of the 10 lesions analyzed. This suggests proofreading by human