Helena Schnell

Scientist | PhD @Uni_Ulm studying how cells recycle their (protein) waste @Harvardmed @BrighamWomens | Former president @INetNYC

[Helena Schnell @HelenaMSchnell]

Everyone has a story.
#INetNYC #InternationalScientistsofNY #instagram #submit #follow
https://t.co/lcATm1dMjW

[INetNYC @INetNYC]

#International scientists of #NewYork - wanna tell your story to the world? INet NYC #Instagram is accepting your stories! Submit to
https://t.co/fSdsjtxmRa

[Helena Schnell @HelenaMSchnell]

Check out our newest output @NatureSMB on filling gaps in proteasome biogenesis: Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis.

https://t.co/mm9SXtzZAl

@SpringerNature @HC2EM @harvardmed @BrighamResearch @BrighamWomens

[Trends in Biochemical Sciences @TrendsBiochem]

Read the Spotlight from @HelenaMSchnell and John Hanna titled "DUB-le vision: snapshots of the #proteasome during substrate processing".

#ubiquitin #DUBs #Usp14 #Ubp6 #Rpn11

https://t.co/WQEfvC6wwW

[Helena Schnell @HelenaMSchnell]

Check out our #spotlight on the recent work by Zhang and Zou et al. on how the deubiquitinating enzyme (DUB) Usp14, regulates, and is regulated by, the proteasome. @TrendsBiochem

https://t.co/26aQu6lCVM

[Helena Schnell @HelenaMSchnell]

Read our latest #research on how Yeast PI31 inhibits the proteasome by a direct multisite mechanism @SpringerNature @natureSMB

https://t.co/PfoyxNxrlv

@HC2EM @harvardmed @BrighamWomens

[Ribbon Diagrams @RibbonDiagrams]

7LS6: Cryo-EM structure of Pre-15S proteasome core particle assembly intermediate purified from Pre3-1 proteasome... https://t.co/aDYtJPXjfQ

[J Cell Science @J_Cell_Sci]

Hanna &co @HelenaMSchnell @BrighamWomens @harvardmed discuss recent developments and structural insights regarding chaperone-mediated assembly of the proteasome core particle: https://t.co/K7broYLfcI

[Helena Schnell @HelenaMSchnell]

Check out our new review on proteasome assembly:

Chaperone-mediated assembly of the proteasome core particle – recent developments and structural insights https://t.co/c0aqVEnJ3u

[INetNYC @INetNYC]

🗣Would you like to know more about your #transferable skills and strengths as a #PhD?
Join us and @postacademia from @germanscholars.
Date:
📅November 16th
⏰12PM (EDT)
https://t.co/6fJGKPD0aY
#postdocs #skills #Webinar

[The FEBS Journal @FEBSJournal]

Reg1 and Snf1 regulate stress-induced relocalization of protein phosphatase-1 to cytoplasmic granules

🖊️By John Hanna and colleagues @harvardmed @LSUHS

🔗https://t.co/raorlvRfXa

#stressgranules #Glc7 #Reg1 #Snf1 #proteinphosphatase1

[Helena Schnell @HelenaMSchnell]

Enlightening article about the significance of GMO fruits & vegetables via @NYTimes https://t.co/aGfX6Vrfe7

[NatureStructMolBiol @NatureSMB]

How to build a proteasome... NVs by Edward Morris & Paula da Fonseca highlighting a recent study by John Hanna & co reporting two CP assembly intermediates
https://t.co/1vQOvbRno5

[3D Protein Imaging @proteinimaging]

One of the latest releases at @EMDB_EMPIAR & @PDBeurope: snapshots of proteasome core particle assembly by John Hanna’s lab @harvardmed @BrighamWomens. Our rendering project - https://t.co/a5V0Ihd8dn

[Brigham and Women’s Research @BrighamResearch]

In @NatureSMB: Using a technique called cryo-electron microscopy, researchers from @BrighamWomens and @HarvardMed visualized two unique proteasome intermediate structures. https://t.co/rXOtvL0HQK

[SBGrid: Structural Biology Software @SBGrid]

Helena Schnell et al report #cryoEM snapshots of proteasome core particle assembly, resolve mostly helical Ump1, infer sequence of core particle maturation events. From John Hanna’s lab @harvardmed @BrighamWomens. SBGrid’s Shaun Rawson contributed. https://t.co/koaF7luIzh

[Helena Schnell @HelenaMSchnell]

Interested in studying structural and functional aspects of proteasome biogenesis?

Our lab is recruiting:
https://t.co/2oYA19fkRc

Shown below is a cryo-EM structure of the 13S proteasome core particle assembly intermediate (3.6 A).

[EMDB - EMPIAR @EBI @EMDB_EMPIAR]

Amongst todays releases at @EMDB_EMPIAR & @PDBeurope is this entry of a Pre3-1 20S proteasome core particle resolved to 2.74 Å by #singleparticle #cryoem.

Map: https://t.co/8pYqb981Hy
Model: https://t.co/j4oJaN8mMd
Paper: https://t.co/KzZ1XQqcI0
EMDB: https://t.co/d9w7tTiL3G

[NatureStructMolBiol @NatureSMB]

Assembling a destruction machine: #cryoEM structures of assembly intermediates of the proteasome 20S core particle reveal early steps in proteasome biogenesis
https://t.co/oVRCG3XOV2

[Helena Schnell @HelenaMSchnell]

Excited to share our recent structural discovery showing the interplay of chaperones with 20S proteasome precursors shedding light on proteasome assembly.

Spoiler: We describe the structure of Ump1!

⁦⁦@NatureSMB⁩ https://t.co/TJRInhOYsu

[INetNYC @INetNYC]

Featured in today's issue of #WomenHistoryMonth is #CUNY and @RockefellerUniv alum, Dr. Linda Molla. She currently is a Senior Project Associate at @Regeneron.
#WomenInSTEM

[Helena Schnell @HelenaMSchnell]

@FEBSJournal

[Helena Schnell @HelenaMSchnell]

My 1st first author paper is published @FEBSJournal:

We show how Reg1 & Snf1 regulate the stress-induced relocalization of protein phosphatase-1 to cytoplasmic granules which is mediated by Cdc48 & PP1 regulatory subunit Ypi1.

Thanks to all co-authors!

https://t.co/6m3tT3s9pu