Hollopeter lab

We use C. elegans to study cellular machines | @Cornell & @Cornellvet | Tweets by lab members

[Hollopeter lab @HollopeterLab]

We want to give a huge thank you to @LaurenCahoon for helping make our #research accessible. Check out her terrific synopsis of our @NatureSMB paper in @CornellVet news! https://t.co/Chnjim7mFp

[Hollopeter lab @HollopeterLab]

Check out our latest #research on #endocytosis published in @NatureSMB! In this collaboration with @therickybaker and @kevcannon520, we use #cryoEM and #biochemistry to discover a new checkpoint in AP2 cargo selection. https://t.co/1IcjZnHuQj

[Hollopeter lab @HollopeterLab]

Working on this has been a blast & we look forward to feedback!! 🤩🪱 4/4

[Hollopeter lab @HollopeterLab]

We’re excited to share our new preprint! We used a wacky C. elegans phenotype to study the homolog of a family of phosphatase regulators. This was a collab between Hollopeter lab members and @guntherwho & proteomics experts @ScienceStowers @LaurenceFlorens and Ying Zhang. 1/4

[bioRxiv @biorxivpreprint]

The C. elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator https://t.co/iArs3KM8Vg #bioRxiv

[Hollopeter lab @HollopeterLab]

Like the ASPPs, APE-1 localizes to cell junctions & binds PP1. Using jowls as a functional readout of the APE-1–PP1 complex we then discovered that localization to cell junctions is conferred by APE-1's N-terminal half, while its C-terminal ankyrin repeats regulate PP1 output.3/4