Curtis "Tug" Hughey

Assistant Professor at the University of Minnesota. Metabolism researcher. Opinions are my own.

[Curtis "Tug" Hughey @Hughey_Lab]

Thanks @APSPublications for sharing our latest work led by @ferrolrome with key contributions from Gregory Shobert, @VoigtWilliam, @dbstagg, @puchatek22ch, @Isotopomer, and @ketonemics

[APS Publications @APSPublications]

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute #exercise but enhances adaptations to exercise training in mice (@ferrolrome, @Hughey_Lab et al. @UMNNews) - new in @AJPEndoMetab

https://t.co/fASj2Cz9Ym

#gluconeogenesis #metabolism

[Vanderbilt MMPC @MouseCentral]

Please join us in Nashville on June 13th as we honor the life and contributions of Dr. David Wasserman. Registration for this event is open until May 2. Please follow the redcap link below to register.

[biorxiv_physio @biorxiv_physio]

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to ... https://t.co/uynDyYl2oR #biorxiv_physio

[Curtis "Tug" Hughey @Hughey_Lab]

Please check out the latest review from the Division of Molecular Medicine @UMN_DOMResearch

We (@puchatek22ch @ketonemics) hope it is a useful resource for those interested in mitochondrial oxidative metabolism in NAFLD.

https://t.co/iwdyXkzNNn

[Curtis "Tug" Hughey @Hughey_Lab]

@_alisanelson Are you referring to that conversation where you brilliantly defended your PhD thesis? On a side note, that review cites some of the great work by @gibalam and colleagues from whom I learned a lot about exercise physiology. I still have my lecture notes! It was a great class btw.

[Daniel J Drucker @DanielJDrucker]

From fasting to anesthesia to rates of glucose infusion, choice of isotopes and more-technical considerations for glucose clamps in mice @MouseCentral @vumcdiabetes @NatMetabolism https://t.co/ieypdf6cNH

[Molecular Metabolism @MolMetab]

This study investigates potential mechanisms by which loss of GNMT suppresses #oxidative #metabolism, particularly relating to #liver lipid accumulation.
@ferrolrome @Hughey_Lab @UMNews @UMN_DOMResearch

➡️https://t.co/SloWO5nyq7

[Luke Norton @SA_Diabetes]

We are looking for a postdoctoral fellow to work on NIH funded studies examining hepatocyte functional heterogeneity in metabolic diseases. Please feel free to contact me for more details.
#sciencejobs #NAFLD #NASH #metabolism #type2diabetes

https://t.co/yaMxruGaL6

[Alisa Nelson, PhD @_alisanelson]

Very happy to share our recent work, "Artifactual fatty acid dimers mimic FAHFA signals in untargeted metabolomics pipelines" published in @jlipidres

https://t.co/UaAgSDkYnM

[UMN DOM Research @UMN_DOMResearch]

Medicine Research Conference
2/14/22
Noon CST
"Gestational Diabetes: How changes in placental development contribute to lifelong metabolic disease risk"
Sarah Wernimont
Department of Obstetrics, Gynecology & Women's Health
Division of Molecular Medicine

https://t.co/f6BX5gUxrn

[Curtis "Tug" Hughey @Hughey_Lab]

@KCKlatt @MolMetab @ferrolrome The enigma that is one-carbon metabolism! In this mouse model, homocysteine remethylation still appears to be a critical node (even though betaine isn't limiting). Perhaps, more consideration given to NAFLD subpopulations or combo approaches (betaine/choline +) is warranted?

[Curtis "Tug" Hughey @Hughey_Lab]

Thrilled to share our work 'Disrupted Liver Oxidative Metabolism in Glycine N-Methyltransferase-Deficient Mice is Mitigated by Dietary Methionine Restriction' @MolMetab

This study was led by the very talented, @ferrolrome
https://t.co/M2ZViSQBpu

[Curtis "Tug" Hughey @Hughey_Lab]

@BrainMetabolism @ferrolrome Genotype and diet appear to impact liver creatine metabolism.

GNMT KO decreases the guanidinoacetate/creatine ratio.

Methionine restriction increases the phosphocreatine/creatine ratio.

Important considerations for the hepatic and extrahepatic phenotypes, and future studies!

[Curtis "Tug" Hughey @Hughey_Lab]

@SA_Diabetes @ferrolrome Thanks, Luke.
I'm not sure I was even needed on this one. Ferrol Rome (@ferrolrome) is an outstanding scientist.

[Curtis "Tug" Hughey @Hughey_Lab]

@JacobsLabUofA @MolMetab @ferrolrome Thanks Rene! I hope you enjoy it.

[Julio Ayala @TheBurro34]

Interested in neuroscience and metabolism? The Ayala Lab at Vanderbilt is looking for a post-doctoral fellow to join our diverse group. Projects focus on gut-brain axis and body weight regulation. Strong neuroscience background preferred. Collaborative environment! Please DM me.

[Curtis "Tug" Hughey @Hughey_Lab]

@CitizensTn I'm glad to hear you're safe and hope you haven't angered anyone by revealing my significant inheritance.

[Curtis "Tug" Hughey @Hughey_Lab]

Congrats @_alisanelson and @ferrolrome!

The Division of Molecular Medicine is extremely proud of you and the terrific work you shared at Research Day in the Department of Medicine.

[Peter Crawford @ketonemics]

Thrilled that @_alisanelson and Ferrol Rome from

https://t.co/l2FKCckTlB

were recognized with awards this year at Research Day in the Department of Medicine.

Congratulations to all awardees and all presenters for sharing your outstanding work.

[Curtis "Tug" Hughey @Hughey_Lab]

@CitizensTn @PaulTitchenell I'm not sure if using mouse fur trimmers to cut your own hair in the lab is appropriately described as very meticulous grooming habits.

[Mohsin Rahim @mohsin_rahim11]

Check out our latest work in @JCI_insight. I’m really proud of this one: