Sean Huth

Aspiring German/American Chemist. Was an undergrad in the Gellman group at UW-Madison (Class of 2020). Currently working in the MacMillan lab at Princeton

[Princeton Chemistry @PrincetonChem]

The @Stache_Lab has discovered that a black pigment present in many plastics drives depolymerization. Their latest two papers, in @ACSPublications and @J_A_C_S, showcase the potential.

Congrats Hanning, Sewon, Liat, Erik, Erin!

Enjoy our feature: https://t.co/igyzKOeGCT

[MacMillan Group @MacMillan_Lab]

Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain!

https://t.co/Pb14UXTdLf

[Steve Knutson @MrSteveKnutson]

🎄A new festive µMap photocatalyst and an RNA-seq workflow for profiling the proteomic & transcriptomic magic of nuclear condensates. 🎁🎁🧬🔬Big congrats to Roderick, Niels, Brandon, Philip, Iakovos and @MacMillan_Lab for this Christmas miracle! ✨✨✨ https://t.co/N9BSm6A8Vt

[MacMillan Group @MacMillan_Lab]

Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean @JacobGeri1 @JamesO760

[MacMillan Group @MacMillan_Lab]

Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean!

https://t.co/NR9eZuq2N7

[Princeton Chemistry @PrincetonChem]

Now out from the @MacMillan_Lab in @nchembio: “µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.”

Congratulations Roderick, Steve, Sean, and Dave on this fine work.

Paper here: https://t.co/8Oza8GJdxP

[MacMillan Group @MacMillan_Lab]

Interested in converting an aliphatic alcohol directly into its bioisostere? Check out our method for deoxydifluoromethylation of alcohols. Congrats to Edna, Nico @cnprietokullmer, and @HoltSakai! Read the full paper out now in @J_A_C_S.

https://t.co/AjzsoZMCCb

[James Oakley @JamesO760]

Excited to share our latest work on small molecule binding site ID. We demonstrate this application across 7 different protein-ligand pairs and in live cells. Really fun team effort with @HuthSean @CiaranSeath @Merck and the rest of the team
https://t.co/UX6YyWJRDk

[MacMillan Group @MacMillan_Lab]

Doubleheader in JACS!
An awesome collaboration with @Merck on leveraging μMap toward the mapping of protein binding sites. Congrats @HuthSean @HuthSean, James, @CiaranSeath, @JacobGeri1, Aaron, and the whole team at Merck!
https://t.co/sngiJTx1oa

[Alice Ting @aliceyting]

I was taken by surprise this morning when congratulatory emails started arriving in my inbox. I'm incredibly honored, grateful, and humbled to be included among such an esteemed group of scientists, many of whom I’ve admired for decades.

While this recognition is individual, science is fundamentally a collaborative and team effort. I wish to express my heartfelt gratitude to my extraordinary trainees whose talent, creativity, resourcefulness and persistence have built everything that our lab is known for and taken our research in directions I had never imagined; to my mentors who ignited my curiosity and led by example; to my collaborators who have introduced me to new fields and inspired me with the beauty of their science; to my colleagues who have so generously supported and advocated for me time and again; and to the community of cell biologists, molecular biologists, and neuroscientists who have trusted and incorporated our technologies into their research, given us invaluable feedback, and inspired us to continue building.

Being able to do science, to expand human understanding of the natural world, is an enormous privilege and joy. I can't wait to see what the future holds for molecular technologies that enable scientists to probe proteins, RNA, and living systems in new ways!

[MacMillan Group @MacMillan_Lab]

In @Nature, our µMap platform synergizes with the @MuirLab's split intein tech, where the power of photo-proximity labeling helps us tracks transient, disease-relevant chromatin interactions. Congrats to
@CiaranSeath, Antony, and the whole team!
https://t.co/815j57aByF

[MacMillan Group @MacMillan_Lab]

Out now in Nature! https://t.co/wQfblTmvfa

[Jiaxin Xie @Miyano1018]

Just found out the final piece of my PhD work has been published in @J_A_C_S I am so grateful to everyone involved in this project, especially my advisor Prof Guangbin Dong, without whom it would not have been possible for me to accomplish this work.

https://t.co/Azzc5snqsV

[MacMillan Group @MacMillan_Lab]

Check out our latest work on the late-stage C–H methylation of drug molecules in JACS! Congrats Edna! https://t.co/miH86sdekE

[Vega Shah @dr_alphalyrae]

Engineering bacteria as interactive cancer therapies | Science https://t.co/9NwgfuNVEd

[MacMillan Group @MacMillan_Lab]

Just out on ChemRxiv! We report a strategy to rapidly access diverse 2-substituted bicyclo[1.1.1]pentanes via new HAT and metallaphotoredox methods. Congrats to the Princeton and Merck Boston team! https://t.co/KuaZRFfQS3

[Kevan Shokat @kevansf]

Taking a BiTE out of KRAS G12C drug resistant tumors with cell surface drug presentation. 🙏 @CraikLab for collaborating on our first adventure in biologics. @bignerdzzy @PRoh_94 @UCSFCancer @HHMINEWS https://t.co/BlCu69WcGQ

[MacMillan Group @MacMillan_Lab]

Using our µMap proximity labeling platform, we report the discovery of novel SARS-CoV-2 entry receptors on the surface of human cells. Congrats @JacobGeri1, @MrSteveKnutson, and @PlossLab!
https://t.co/DB8aJbjL5n

[MacMillan Group @MacMillan_Lab]

Just out in PNAS! We report the application of µMap to identify protein targets of small molecule drugs. Both intra- and extracellular targets are demonstrated herein. Great work to the entire team!
https://t.co/t8aztJHmNx

[MacMillan Group @MacMillan_Lab]

In @J_A_C_S, we report a platform for red-light photoproximity labeling as we move toward in vivo applications. Congrats to @BenitoBuksh, @MrSteveKnutson, @JamesO760, @CiaranSeath, collaborators from the Scholes Lab and @PlossLab, & the whole team! https://t.co/9aF6C4QvTb