【The 5 Ds of outpatient antibiotic stewardship for UTI】
Let's review 5Ds model of stewardship for UTI
・Diagnosis
・Drug
・Dose
・Duration
・De-escalation
Level: Basic
#IDMedEd#IDFellow#MedEd#IMResident
📢 Penicillin allergy ≠ no cefazolin.
More evidence to support cefazolin for most patients with reported β-lactam allergies undergoing surgery.
💉 Let’s move beyond outdated allergy labels and improve patient care! 🦠
https://t.co/WcikQ0N5mQ
#IDTwitter
Great news!
F2G and Shionogi Announce Positive Topline Results from Global Phase 3 OASIS Study Evaluating Oral Olorofim Versus AmBisome® Followed by Standard of Care in Patients with Invasive Aspergillosis whose infection was either refractory to or unsuitable for azole therapy
The study achieved the primary endpoint of non-inferiority, with a rate of all-cause mortality (ACM) at Day 42 for olorofim of 23.8% and for AmBisome® followed by standard of care of 24.3%
https://t.co/FWXklSN2Ma
C. auris is a frequently multidrug-resistant emerging fungal pathogen able to persist and spread within healthcare environments.
In @CIDJournal, authors describe their institutional experience with C. auris detection via universal screening. https://t.co/81IRz5YswY
This 19-year-old shared her story of going blind after showering with contact lenses in the Dominican Republic.
Contaminated tap water containing parasites infected her contact lenses and cornea, causing severe keratitis.
She was initially misdiagnosed and given steroid drops that worsened the infection, leading to complete blindness in both eyes within a week.
Further testing led to a diagnosis of Acanthamoeba infection, a form of amoeba. After intensive anti-parasitic eye drops every 30-60 minutes for 6-12 months, vision has been partially restored in her left eye only.
Acanthamoeba is common in tap water, showers, pools, and lakes worldwide. Avoid washing or exposing contact lenses to tap water as this can potentially lead to blindness.
Geospatial targeting of TB screening in Uganda reduced screening volume by 92%, increased TB yield by 10%, and cut costs by >90%. Surveillance data can help find more TB with fewer resources
https://t.co/x9xvE0scHJ
Excellent review!👍📰
Learn about
1⃣Carbapenemase classification and characteristics
2⃣Evidence-based treatment recommendations
3⃣ Where are the carbapenemases
4⃣ Changes in global landscape 🌏
🔗https://t.co/X9EAfbSV8R
🆕💥🟢Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin (cephalexin and cefadroxil) Dosing for Skin and Soft Tissue Infections in the 21st Century
🔺The authors summarize clinical and PK/PD data that compare dosing strategies for SSTIs.
🔺Conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus aureus and Group A Streptococcus
🔺Given potential risks of underdosing due to obesity, non-adherence with frequently dosed regimens, and inadequate PTA in higher MIC organisms (e.g., MSSA), the authors favor using higher-dosed regimens such as cephalexin 1000 mg three times daily or cefadroxil 1000 mg two times daily for moderate–severe SSTIs #idxposts
https://t.co/PjjkA5kTX1
Hot off the press!♨️ Excellent review article📜 on Staphylococcus aureus bacteremia.🦠🩸
"Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management"
Available at 🔗https://t.co/WfZ8lJEtFm
#IDXposts
Have you ever heard of the Eagle effect?
When more kills less.
One of microbiology's most intriguing paradoxes: sometimes higher antibiotic concentrations result in less bacterial killing.
This phenomenon has even been proposed as a potential rationale for combination therapy.
#CongresoSEIMC2026 | ❗🏆 Ya conocemos los ganadores de los premios #SEIMC "Amadeo Foz" y "Moreno López"
Estos #galardones reconocen, respectivamente, la labor de un #microbiólogo y un #infectólogo que hayan realizando una contribución significativa al desarrollo de estas especialidades
➡️ El Dr. Luis Martínez, jefe del Servicio de #Microbiología de @HUReinaSofia, recibe el Premio "Amadeo Foz"
➡️ El Dr. Jesús Rodríguez-Baño (@jesusrbano), jefe del Servicio de Enfermedades Infecciosas del @HUVMacarena, galardonado con el premio "Moreno López"
👏 ¡Enhorabuena a ambos!
📣 Don't forget, the call to submit proposals for ESCMID guidelines projects is open!
The ESCMID Guidelines Subcommittee invites interested parties to propose and undertake the development of full clinical practice guidelines on behalf of ESCMID.
💡Info: https://t.co/UDhC9kLk80