Ivelin Georgiev, Ph.D.

Georgiev Lab at Vanderbilt, focusing on computational immunology and vaccine research.

[Ivelin Georgiev, Ph.D. @IG_lab]

https://t.co/sut5L09vFa

[Ivelin Georgiev, Ph.D. @IG_lab]

RSV & hMPV remain unmet needs. In @CellRepMed, we report #LIBRAseq-discovered cross-reactive #antibodies that neutralize both #viruses. mAb 5-1 shows strong potency, in vivo protection, broader reactivity than current leads, and features supporting translational development.

[Kelsey Voss @DoctorKvoss]

Check out this exciting collaboration with @IG_lab now available as a preprint-
Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies https://t.co/l5zNrFlqeX
So fun to take this risk and watch it succeed. 🍾

[vaccine_clint @ClintVaccine]

@IG_lab @AlexisJanke @IanSetliff @KelseyPilewski @LaurenW_Science The paper has finally been published open access in Patterns! Read it here: https://t.co/JTxLgqiTg1

[Cell @CellCellPress]

Now online! Generation of antigen-specific paired-chain antibodies using large language models https://t.co/Qdaj0UQtd5

[Andy Kilianski @AndyKilianski]

Great work by @IG_lab and @VUMCDiscoveries on open-source AI tools for de novo biologics design and development. MAGE paves the way for target-agnostic mAb tools for all disease. Excited to be a part of it @ARPA_H - AI biodesign tools for everyone!

https://t.co/v5S9AcELXy

[César de la Fuente @delafuentelab]

Fantastic panel discussion with the great @y_bromberg, @IG_lab, and Theresa Koehler on the latest advances in #AI for antibiotic discovery and microbiology at @ASMicrobiology #ASMicrobe. Exciting times for science!

[Ivelin Georgiev, Ph.D. @IG_lab]

SynAbLib: an expandable synthetic library of human paired #antibody sequences.

https://t.co/KcYOMuQR3g

[Vanderbilt University Medical Center @VUMCDiscoveries]

An ambitious project led by @VUMChealth investigators aims to use #AI technologies to generate antibody therapies against any antigen target of interest.

@IG_lab will serve as the project principal investigator.
https://t.co/KztblB4iee

[vaccine_clint @ClintVaccine]

This work wouldn't have been possible without my PI @IG_lab ; our amazing experimentalist @AlexisJanke ; and the LIBRA-seq data producers Andrea Shiakolas, @IanSetliff, @KelseyPilewski, and @LaurenW_Science

Hopefully you'll find our methods and models useful! Models drop soon

[vaccine_clint @ClintVaccine]

🧬My new paper is up on bioRxiv!
Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery

📄 https://t.co/sgdEH5gyzY
@IG_lab
#Immunology #MachineLearning #LIBRAseq 🧵1/5

[Ivelin Georgiev, Ph.D. @IG_lab]

Using #antibody sequence alone, can we predict whether two antibodies target overlapping epitopes? A new suite of algorithms developed by @ClintVaccine:

Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery https://t.co/xblFi3ntT7

[vaccine_clint @ClintVaccine]

Happy to be part of a disruptive project out of my lab. Essentially #ChatGPTForAntibodies — feed in an antigen sequence and it returns an antibody sequence that has a high probability of binding.

[Ivelin Georgiev, Ph.D. @IG_lab]

A few highlights of MAGE (Monoclonal Antibody GEnerator):
1. Input is only #antigen (target) sequence, no structures or models needed.
2. Output is fully human paired heavy-light chain #antibodies.
3. MAGE was validated to work for known or related targets, with high hit rates.

[Ivelin Georgiev, Ph.D. @IG_lab]

Monoclonal antibodies are crucial in medicine and research, but their discovery is slow, costly, and complex. What if #AI could change this - creating fully human #antibodies, on demand, for a target of interest? The magic is in #MAGE:

https://t.co/GBRj3RL6IC

[Biology+AI Daily @BiologyAIDaily]

Generation of antigen-specific paired heavy-light chain antibody sequences using large language models

1. The study introduces MAGE, a groundbreaking protein large language model (LLM) designed to generate antigen-specific paired heavy and light chain antibody sequences, showcasing the potential of AI in revolutionizing antibody discovery.

2. MAGE uniquely eliminates the need for pre-existing antibody templates or structural information, relying solely on antigen sequences to produce functional and novel antibody designs with experimental validation.

3. Validation experiments highlight MAGE's ability to create diverse antibodies against critical targets like SARS-CoV-2, H5N1 avian influenza, and RSV-A, demonstrating its versatility and broad applicability.

4. A standout achievement includes zero-shot learning capabilities, where MAGE generated effective antibodies for the unseen H5N1 variant, proving its value in addressing emerging health threats rapidly.

5. Structural analyses reveal that MAGE-designed antibodies bind to distinct epitopes, showcasing novel binding modes and demonstrating their potential for therapeutic application.

6. The study underlines MAGE's ability to design antibodies with potent neutralization capabilities, such as against SARS-CoV-2 variants, including Omicron, indicating its relevance in vaccine and therapeutic development.

7. By leveraging a curated dataset and advanced machine learning techniques, MAGE achieves high novelty and diversity in its antibody sequences, expanding the possibilities for antibody engineering.

8. The research emphasizes that MAGE can significantly accelerate antibody discovery processes, overcoming traditional bottlenecks like inefficiency, high costs, and long timelines.

9. Future applications of MAGE promise to extend beyond virology, potentially transforming fields like oncology and autoimmune disease treatment with AI-driven antibody generation.

@IG_lab @McLellan_Lab @DannySheward @HelenChuMD
📜Paper: https://t.co/fO6JcgjX2w

#AI #AntibodyDiscovery #Bioinformatics #ProteinDesign #MachineLearning

[Ivelin Georgiev, Ph.D. @IG_lab]

This manuscript is now published in Bioinformatics Advances: Optimizing #LIBRAseq #antibody-#antigen specificity assignments

Negative Binomial Mixture Model for Identification of Noise in Antibody-Antigen Specificity Predictions from Single-Cell Data https://t.co/7PbSz8dCDE

[Ivelin Georgiev, Ph.D. @IG_lab]

A potently #neutralizing and protective human #antibody with a unique antigenic footprint on #RSV and #hMPV fusion glycoproteins. Collaborative work with @McLellan_Lab @jjmousa @BonamiRachel @croweje @RHCarnahan, and others.

https://t.co/T3IcpUfqmH

[Ivelin Georgiev, Ph.D. @IG_lab]

This paper is now published in Structure: An exceptionally broad #coronavirus #antibody.

[Ivelin Georgiev, Ph.D. @IG_lab]

A protective pan-betacoronavirus #antibody that also recognizes zoonotic alpha- and delta- #coronaviruses. Multi-year effort led by Nicole Johnson, Steven Wall, Kevin Kramer, @ClintVaccine, in collab with @McLellan_Lab, Giuseppe Sautto, and many others.
https://t.co/8ZlUmgxNSh

[Priyamvada Acharya @PriyamvadaA_Lab]

Check out this paper on broadly reactive IgG3 antibodies led by Matt Vukovich @IG_lab. Backstory here is that our collaboration was accelerated by Matt's visit to our lab @DukeU under the Duke Center for HIV Structural Biology Trainee Exchange program @DukeHIVStrucBio