Ian Seiple

Associate Professor at UCSF. Opinions are my own. He/him.

[Andrew Ecker @EckerChem]

Is 2026 the year of arginine?
Covalent discovery and chemical proteomics have largely focused on cysteine and lysine, leaving other functionally critical residues underexplored.
In our new preprint, our joint Seiple and Zaro Lab team asked: Can arginine be targeted covalently? 🧵

[Neha Prasad @nehakprasad9]

Get ready for a 6-part series on #antibacterial development news highlights, editorialized by yours truly! In Part 1, I've contextualized live biotherapeutic products in the C. difficile therapy landscape.
Give it a read & a comment so we can all learn.
https://t.co/4pFaktIa1o

[Ian Seiple @IanSeiple]

Here's the mold to pour the large plates.

[Ian Seiple @IanSeiple]

Weight set / power rack I built during lockdown. The only things that didn't come from the hardware store were the bar, the bench, and the clips. Fun project, and still using it 3 years later!

#ChemistsWhoLift

[Ian Seiple @IanSeiple]

Back on twitter with a ✨shimmer✨ Follow @theseiplelabucsf on “tick tock” #TikTok #chemtwitter #realtimechem https://t.co/JoJMvtGab3

[Ziyang Zhang @bignerdzzy]

Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: https://t.co/GWj1Wzcugq Interested in more? The Zhang lab (https://t.co/Fm4hoDMWpP) at @UCBerkeley is recruiting:)

[John H. Rex, MD @JohnRex_NewAbx]

The recent @ASMicrobiology paper entitled "Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020" is a must read.

Check it out now!

@nehakprasad9 @IanSeiple
#FireExtinguishersOfMedicine
#AMRSOS #StopSuperbugs
https://t.co/dQg5z6LJQy

[Fujimori Lab UCSF @FujimoriLabUCSF]

Our latest: https://t.co/SFUVajqEXN @eLife

[J. Am. Chem. Soc. @J_A_C_S]

✨ One of our most read articles in the last 12 months! ✨
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 by Cotton, Nguyen, Gramespacher, @IanSeiple & @realJimWells 
🔓 #OpenAccess https://t.co/k3gtcsSWUV

[Medicinal & Bioorganic Chemistry Conference @MedicinalBioor1]

Welcome to the speakers for Monday 31st January at #MBCF2022 - you can view the full line up of 40 speakers for the 15th Winter 'Medicinal & Bioorganic Chemistry' Conference at Steamboat Springs, Colorado on the MBCF website at https://t.co/Ue2Ma9EQzp

[Ian Seiple @IanSeiple]

@Amgen @TheNelsonLab @HysterLab @XiaochenBai @pdhsu Thrilled to be a part of this group. Thank you, @Amgen !

[Ian Seiple @IanSeiple]

Attention all professors also.

[Tehshik Yoon @TehshikYoon]

Hello NSF fellowship applicants! This is my annual reminder that you almost certainly mean "precedent" and not "precedence".

[Ian Seiple @IanSeiple]

Back when @hanzyduzit was pressuring me to finish palau’amine…

[Ian Seiple @IanSeiple]

@DMart_82 It’s not weird, just expect a rejection!

[Ian Seiple @IanSeiple]

@abbybuch We use Amazon echo and it connected to network with no issue. Great for music and timers

[Ian Seiple @IanSeiple]

@S_Grella I had to trade an Unlimited Mox Jet for my position :(

[Ziyang Zhang @bignerdzzy]

Super honored to be part of this! Just happy to be in the field with all the cheerful and bright scientists! Big thank you to my collegues and mentors who helped and supported me and my science especially @HarvardCCB @UCSF @UCB_Chemistry

[Ian Seiple @IanSeiple]

This amazing work by @adamcotton92 in collaboration with @realJimWells is now published in ACS @ChemicalBiology !

See the updated story here: https://t.co/zPNJn4KVwZ

Now includes a direct comparison of BioReACT-labeled antibodies to Halo/SNAP/CLIP fusions. Must see!

[Ian Seiple @IanSeiple]

1/7 Check out our new method to selectively label biotin-containing biomolecules, BioReACT! This work all by the talented @adamcotton1992 in collaboration with @realjimwells. https://t.co/iWoyy1TrfR.