IctalGroup

Neurocritical Care Research Network | Status Epilepticus · Critical Care EEG · Acute Brain Injury | Research · Education · Collaboration | #ICTALRegistry

[IctalGroup @IctalGroup]

🧠🌊 Welcome to IctalGroup.

We are a #NeurocriticalCare research network focused on #StatusEpilepticus, Critical Care #EEG and Acute Brain Injury.

🤝 Follow us for new studies, key publications, educational content and opportunities to collaborate. #ictalRegistry

[IctalGroup @IctalGroup]

Post-cardiac arrest meta-analysis: strict NCSE/ESE/PSE occurred in 22% of EEG-monitored comatose survivors (112/457; 95% CI 10–41%). Poor outcome and mortality were frequent, but estimates were highly heterogeneous.
https://t.co/DjApaAZ9Ah

[IctalGroup @IctalGroup]

How much does access to EEG matter in #statusepilepticus?
In 163 adults with EEG-confirmed NCSE, externally validated in 906 patients, longer delays to EEG were associated with worse functional outcomes and higher mortality.
https://t.co/wiVQFH2b2w

[IctalGroup @IctalGroup]

Does timing of treatment matter for neuronal injury in #statusepilepticus?
In an experimental rat model, early phenobarbital treatment prevented the reductions in N-acetylaspartate and neuronal loss observed after untreated SE.
https://t.co/5w2VOpVEWz

[IctalGroup @IctalGroup]

NCSE can mimic acute stroke — including with ictal paresis.
In this 6-patient series, perfusion imaging helped identify the ictal origin when EEG findings were less informative.
A rare but clinically important presentation.
https://t.co/zoutqGizsW⁠ @phi3417 @SeizureJournal

[IctalGroup @IctalGroup]

🔥 New from the #ICTALRegistry in @GreenJournal !
How much do etiologic investigations actually tell us after #statusepilepticus — and how often do they change management?
Congrats to Sébastien Repplinger & the entire @IctalGroup team! 🧠⚡
DOI: 10.1212/WNL.0000000000218544

[Richard Choi, DO, FNCS @rkchoi]

1/ Hello #medtwitter #medsky #neurotwitter #neurosky #neurocritcare #FOAMEd #MEdEd, today we will be breaking down another article from @neurocritcarej about 🧠 O2 after cardiac arrest!
https://t.co/nPvEi8b2Lf

[Christoph P. Beier @epilepsiOUH]

The neuropathology of "dementia epileptica"

Read the full OA article on "Hyperphosphorylated tau pathology in patients with epilepsy and dementia"
on
https://t.co/WPWA8tjK0V

[IctalGroup @IctalGroup]

Could seizure timing predict response to IV antiseizure medications?
In critically ill patients undergoing #cEEG, greater seizure periodicity was associated with a lower probability of post-treatment remission.
Small, hypothesis-generating study.
https://t.co/uJTpXatYy0⁠ #EEG

[Hector Meza Comparan, MD @HectorMezaMD]

Check out our newest paper here 👇🏻 https://t.co/F6ex4lH7VW

[IctalGroup @IctalGroup]

Can non-invasive neuromodulation play a role in Super Refractory #StatusEpilepticus #SRSE ?
In a prospective series of 20 adults, adjunctive cathodal #tDCS was feasible and well tolerated; 4/20 showed short-term clinical + EEG improvement.
@BioMedCentral

https://t.co/FwEBzoOBLv

[IctalGroup @IctalGroup]

Could enteral vigabatrin become an option for post-anoxic #statusepilepticus?
In 6 comatose patients with electrographic SE, loading doses achieved measurable absorption despite critical illness.
A first PK step — not evidence of efficacy.
https://t.co/RNQ1oOsXAy

[IctalGroup @IctalGroup]

Out-of-hospital diazepam nasal spray was evaluated in 402 tonic–clonic #StatusEpilepticus episodes (>5 min): 61.7% ended before 30 min, 49.8% within 20 min of dosing, and <5% recurred within 24 h.
Retrospective pooled analysis.
@EpilepsiaJourn
https://t.co/yelopw5got

[Stephan A Mayer @stephanamayer]

Out of hospital cardiac arrest with successful resuscitation in the field complicates 1% of hospitalized #SAH cases. The chance of discharge with a good neurological outcome is only 5%. Mortalitty rate is >90%, and the few remaining patients are Rankin 4 or 5.

The survivors have shorter arrests, getlkess EPI, are untrensively monitored and have long ICU stays.

At least recovery os possible, justifying a fight in the ICU if the family is up for it.

#curingcoma

https://t.co/UXkPxdBKvO

[IctalGroup @IctalGroup]

In 145 adults with #StatusEpilepticus, 55% developed RSE and 47% of RSE received therapeutic coma. Worse outcomes with coma were no longer significant after adjustment, highlighting strong treatment-selection effects. @EpilepsyBehavi1

https://t.co/zcUXwdrWvs

[IctalGroup @IctalGroup]

Therapeutic coma in NonConvulsive #statusepilepticus was associated with more pneumonia, sepsis, arrhythmias, acute kidney injury and in-hospital mortality (adjusted RR 1.86), without better seizure termination

https://t.co/AIfRWJoGEv

[IctalGroup @IctalGroup]

Why do some episodes of #statusepilepticus become refractory?

In 649 nonhypoxic SE episodes, acute primary CNS, progressive and unknown causes were associated with super-refractoriness. @EpilepsiaJourn

Etiologic granularity matters.
https://t.co/MDRPIiDVst

[IctalGroup @IctalGroup]

🧠🌊 Welcome to IctalGroup.

We are a #NeurocriticalCare research network focused on #StatusEpilepticus, Critical Care #EEG and Acute Brain Injury.

🤝 Follow us for new studies, key publications, educational content and opportunities to collaborate. #ictalRegistry

[Legriel Stéphane @stlegriel]

Only 19% of 273 prehospital #statusepilepticus episodes received guideline-consistent first-line treatment.
Longer delays to benzodiazepines were associated with worse hospital course
@SeizureJournal https://t.co/TpFXleV48j

.

[IctalGroup @IctalGroup]

Ambulatory EEG captured seizures in 12% of 382 patients with epilepsy and 80% were subclinical. Mild cognitive impairment strongly predicted seizure detection (OR 6.13). Objective monitoring may reveal a substantial hidden seizure burden. @EpilepsiaJourn
https://t.co/2T8SdJ9AHM

[IctalGroup @IctalGroup]

In non-anoxic NCSE, underdosing antiseizure medications was associated with treatment failure and in-hospital mortality.

🚨 Maybe in NCSE, adequate dosing matters as much as the treatment sequence.

Misirocchi et al. @Epilepsia https://t.co/CmV7tSpOBh

#StatusEpilepticus #EEG