Christoph P. Beier

Professor of Neurology - Head of the Epilepsy Reseach Group at the Odense University Hospital

[John J. Millichap MD @JohnMillichapMD]

Early treatment prevents neuronal loss in experimental status epilepticus: A magnetic resonance spectroscopic imaging study https://t.co/QHXsOvGvRy #Neurology #Epilepsy

[Christoph P. Beier @epilepsiOUH]

The neuropathology of "dementia epileptica"

Read the full OA article on "Hyperphosphorylated tau pathology in patients with epilepsy and dementia"
on
https://t.co/WPWA8tjK0V

[Christoph P. Beier @epilepsiOUH]

@stephanamayer @WMCHealth @nymedcollege I couldn’t agree more. Nice work 👍

[IctalGroup @IctalGroup]

Can non-invasive neuromodulation play a role in Super Refractory #StatusEpilepticus #SRSE ?
In a prospective series of 20 adults, adjunctive cathodal #tDCS was feasible and well tolerated; 4/20 showed short-term clinical + EEG improvement.
@BioMedCentral

https://t.co/FwEBzoOBLv

[Legriel Stéphane @stlegriel]

We recently discussed the need for OH data before extending rescue-treatment findings to #statusepilepticus. Here they are — 402 episodes meeting the >5-min definition. Encouraging observational data, although the lack of a control group still prevents efficacy claims.

[John J. Millichap MD @JohnMillichapMD]

Hyperphosphorylated tau pathology in patients with epilepsy and dementia - Neuropathological insights from a historical autopsy cohort https://t.co/3kMA2LbwvT #Neurology #Epilepsy

[John J. Millichap MD @JohnMillichapMD]

Intranasal midazolam vs mouth-dissolving clobazam in terminating seizures: A randomized controlled trial https://t.co/RjY7mYFXkC #Neurology #Epilepsy

[Legriel Stéphane @stlegriel]

Health-Related quality of life after #statusepilepticus : A cross-sectional study from the ICTAL registry - Epilepsy & Behavior @JacqGwen @IctalGroup
@EpilepsyBehavi1 #HrQol
https://t.co/ZnelBQtw51

[Legriel Stéphane @stlegriel]

Major study on super-refractory #statusepilepticus. Even after >28 d of treatment, seizure cessation remained possible and mortality did not increase. Functional outcomes remain poor, but prolonged treatment should not automatically be considered futile. @JAMANeuro @epilepsiOUH

[Christoph P. Beier @epilepsiOUH]

Cost of waiting: association of EEG delay and poor functional outcome in adult status epilepticus

https://t.co/WjTEbU9rGw

[Neuropediatrics® @PedNeurol]

Cost of waiting: association of EEG delay and poor functional outcome in adult status epilepticus https://t.co/MiXLjSafMs

[Christoph P. Beier @epilepsiOUH]

The main findings in this reprint are:
· seizure localisation and epilepsy duration are associated with the presence of pTau deposits.
· the extent of these deposits does not explain the clinical symptoms of dementia observed in the patients.

[Christoph P. Beier @epilepsiOUH]

The neuropathology of “dementia epileptica”

An association between epilepsy and dementia is well established, but what is the link?
We here studied a historical cohort of patients that died between 1945-1982 with epilepsy and dementia
https://t.co/uWFt67ON1p

[Epilepsia @EpilepsiaJourn]

NfL and GFAP are significantly elevated in more than half of adults with drug-resistant epilepsy and intellectual disability compared to healthy controls.
https://t.co/63Vu8d4GYw

#epilepsy #ilae #epilepsiajourn #Alzheimersdisease #dementia #intellectualdisability #serumbiomarker

[Epilepsia @EpilepsiaJourn]

Patients with IIC and SE have similar rates of PMA, suggesting that IIC could actually be nonconvulsive SE.
https://t.co/UyKXJaWecQ

#epilepsy #ILAE #epilepsiajourn #diffusionrestrictedlesion #EEG #lateralizedperiodicdischarges #periictalMRIabnormalities

[Stephan A Mayer @stephanamayer]

We should be moving to ketamine faster for refractory status. In this meta-analysis

1. Response rate was 64%
2. Median maintenance dose 2.5 mg/kg/hr,
3. Dose was the same between responders and non-responders. But... responders were started on KET earlier (3.2 vs 4.3 days)
4. Avg duration of KET 5 days
5. Minimal complications (<1%)

#curingcoma

https://t.co/fW7UQlmTDg

[Epilepsia @EpilepsiaJourn]

Cohort study where we identified 6,295 patients with IGE and 62, 950 normal population controls in the Danish National Patient Register.
https://t.co/ItLc20rGvy

#epilepsy #ILAE #epilepsia #idiopathicgeneralizedepilepsy #mortality #socialoutcome #statusepilepticus #IGE

[Christoph P. Beier @epilepsiOUH]

@EpilepsiaJourn

[Christoph P. Beier @epilepsiOUH]

Status epilepticus = status epilepticus?
Are all status epilepticus equal? No!!!

In a population-based study in Denmark, all patients with, for example, juvenile myoclonic epilepsy or other idiopathic generalized epilepsy AND status epilepticus were examined.

[Christoph P. Beier @epilepsiOUH]

This indicate that status epilepticus in IGE patients is a distict disease entity.

Read the article in Epilepsia:

https://t.co/n03sCHFYQs

[Christoph P. Beier @epilepsiOUH]

All-cause mortality was nevertheless increased, albeit at a low level. The causes of death were all attributable to social disadvantage.
These results differ completely from other forms of status epilepticus, which have a mortality rate of over 50%!