Ignatova Lab

A lab of #RNA lovers, obsessed with tRNA, translational control in protein biogenesis and disease. #translation #ribosome #mRNA #tRNA #SNP 🇺🇦

[Ignatova Lab @IgnatovaLab]

@rubenlgonzalez @Nature Congrats Ruben! Terrific stuff!

[Suzuki Lab. @SuzukiRNALab]

The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation:
https://t.co/eE11ZOb3xl

#tRNA2024

[Eran Meshorer @meshorer1]

That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.

[Ignatova Lab @IgnatovaLab]

Highly recommended! PhD students apply

[Suparna Sanyal @sanyal_suparna]

We are looking for a highly motivated PhD student to explore molecular mechanisms of protein synthesis using fast kinetics and cryo-EM. Pls share the link or apply! https://t.co/mt49j4OODI

[Tevard Biosciences @TevardB]

At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: https://t.co/UKijOZrAac #WDAD24

[Babak Javid @javid_lab]

Preprint alert in collaboration with @fraser_lab !

We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation!

Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA https://t.co/3nFkwBfTNV

[Tevard Biosciences @TevardB]

We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: https://t.co/hBoaOHpeQs #RNALeaders

[Slavov Laboratory @slavovLab]

We report many proteins not predicted by the genetic code.

They are stable & abundant O( 10³ ) copies / cell.

Generative mechanisms include codon-anticodon mismatches & RNA modifications.

Their abundance depends on codon frequency & protein stability.

https://t.co/lAxvulC4zx

[Slavov Laboratory @slavovLab]

Single-cell proteomics helped answer a fundamental question in development:

The molecule mechanisms of symmetry breaking in early mammalian development.

A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.

[Ignatova Lab @IgnatovaLab]

@DjuranovicLab What fo they tell us, besides being more :)

[Jinwei Zhang Lab @jinweizhang]

How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in
@PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. https://t.co/1IjEEPuGJ6

[Ignatova Lab @IgnatovaLab]

@JanUlrikDahl1 @IllinoisStateU @ISUResearch Awesome Jan! It not only rains on your street, it poors - hsppy for you! Looking forward to seeing you soon in HH and catching up :)

[Davide Ruggero @RuggeroDavide]

I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer.

https://t.co/Jd2hXw2Dn6

[Ignatova Lab @IgnatovaLab]

@MiriKrupkin @D_Rothschild_ @mbarnalab @jkpritch @xsui98 @WangXiaoLab @spence_jeffrey_ Congrats Daphna!

[nature @Nature]

Nature research paper: The ribosome lowers the entropic penalty of protein folding https://t.co/dE7OGKEPjz

[Ignatova Lab @IgnatovaLab]

@chofski @BristolUni @BristolBioSci @BrisBioDesign @JGIBristol @turinginst @royalsociety Congratulation, Tom! Fully deserved!

[Ignatova Lab @IgnatovaLab]

Happy (t)RNA day! #RNADay
Thank you to our first author baker Vale @Vblancoca - our terrific guest from @jptosar lab - who orchestrated the baking process.

[Valentina Blanco @Vblancoca]

Happy #RNADay! 🎉

Celebrating in Germany with the incredible scientists/bakers at @IgnatovaLab

Check out our entry for the @RNASociety cake competition! 🍰🔬

We hope sharing our creation here is as welcomed as uploading a paper on @biorxivpreprint🤞

@jrRNAscientists

[Ignatova Lab @IgnatovaLab]

@OdedRechavi Cool stuff! Can you deliver other macromolecules? Small RNAs?

[Martin Picard @MitoPsychoBio]

The time to think and inquire are precious.

Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery.

https://t.co/vWgTsld4uJ