Association between low folate status and mitochondrial #DNA (mtDNA) instability, and cerebral folate deficiency is relatively frequent in #mitochondrialdisorders.
Reference: Ormazabal A et al. Drug Discov Today. 2015 Nov;20(11):1349-54
Association between low folate status and mitochondrial #DNA (mtDNA) instability, and cerebral folate deficiency is relatively frequent in #mitochondrialdisorders.
Reference: Ormazabal A et al. Drug Discov Today. 2015 Nov;20(11):1349-54
Loss of the catalytic activity of the #mitochondrialfolate enzyme serine hydroxymethyltransferase 2 (SHMT2), but not of other #folate enzymes, leads to defective oxidative phosphorylation in human cells due to impaired mitochondrial translation.
A Potential Mechanistic Role for Neuroinflammation in Reward Processing Impairments in Autism Spectrum Disorder. - PubMed - NCBI https://t.co/u4mORlADvU