Infectopeds

Curated by Fabrizio Motta & team. Pediatric ID pearls, papers & updates. Follow @infectopeds on X and IG.

[Brad Spellberg @BradSpellberg]

@ABsteward found 2 new oral vs. IV RCT in kids < 2 mos with possible serious bacterial infxn. More than 12,000 pts! Oral was non inferior in 1 and superior to IV-only in the other on mortality!
Time to stop Tx our own anxiety with IV abx while hurting pts! https://t.co/F9Whl4lYvM

[Infectopeds @Infectopeds]

From high-dose sulbactam to ceftazidime-avibactam + aztreonam, this article sets new pediatric dosing standards for tough gram-negative infections.
https://t.co/yNQhs4zgOR
#PediatricID #AMR #Stewardship #InfectiousDiseases #BetaLactams #InfectoPeds

[Infectopeds @Infectopeds]

Shorter is better, even in pediatric high-risk febrile neutropenia: reducing antibiotics was safe, with no increase in mortality, faster discharge, and >30% fewer antibiotic days.
@BradSpellberg @ABsteward
https://t.co/EwE413cLyv

[Brad Spellberg @BradSpellberg]

Question for MedTwitter. Putting together this new table for Oral Is the New IV, I got to wondering. Is anyone aware of any RCT for any disease in which IV-only abx were superior in efficacy to oral antibiotics? I am having a hard time finding one.

[Infectopeds @Infectopeds]

Static abd cidal👏👏

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🌟Excellent podcast
A debate on antibiotic choices and the controversy between bactericidal and bacteriostatic antibiotics
@BradSpellberg @SuperBugDoc #IDXposts
https://t.co/ov0yAskgrz

[Infectopeds @Infectopeds]

New generation of doctors vs. traditional bosses: who adapts and who gets left behind? A necessary reflection on how medicine is evolving! Check out the article! https://t.co/ejDjtB8cbe #Medicina #Liderança

[Infectopeds @Infectopeds]

Challenging Dogma in the Treatment of Childhood Infections Oral Antibiotics and Shorter Durations by @BradSpellberg
And colleagues

https://t.co/RFrTaG3Jao

[Infectopeds @Infectopeds]

@BradSpellberg Totally agree. Let’s keep pushing forward—change starts with each prescription.🙏💪👏

[Infectopeds @Infectopeds]

Over 75% of pediatricians still prescribe long courses for uncomplicated CAP and UTI.
Are we ignoring the evidence?
“Shorter is better,” as @BradSpellberg says.
📉 Time to change the standard. https://t.co/2EFAkSoJKY
#shorterisbetter #pediatrics #antibiotics #stewardship

[Infectopeds @Infectopeds]

Bronchoalveolar lavage in immunocompromised children: high diagnostic yield, low risk—yet still underused. Time to rethink hesitation? https://t.co/zyu5GaLCYz"

[Infectopeds @Infectopeds]

Is it time to ditch 'decolonization' and embrace 'microbial management' in NICUs? This review makes a strong case that wiping out bacteria may be more nonsense than sense. https://t.co/DAkwIOWMYH"
#stewardship @ABsteward @BradSpellberg

[Infectopeds @Infectopeds]

@BradSpellberg Count on me!

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Just published 🔥
IDSA 2025 Clinical Practice Guideline Update by on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults,Children & Pregnant People #IDXposts
https://t.co/xeCCGMGES1

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥🔥 NEW 🔥🔥
Year In Review: Top Infectious Diseases Articles From 2024
Our new post, a great collaboration with my friend
🌟 @IDstewardship
1️⃣6️⃣⚡️🆔 RCTs
@JAMA_current @TheLancet ✨
7️⃣Syst Reviews/Meta
3️⃣🌏Guidelines
@Wiki_Guidelines ✨️
#idxposts
https://t.co/8YWtXqoyrx

[Despoina Mavridou @bondSSbond]

You want to run antibiotic MICs according to best-practice clinical microbiology protocols, but you are not sure how? Our article will walk you through it all! Great to work with @nikikaderabkova @AyeshaMahmood2 and a pleasure to publish in @npjAMR. https://t.co/pvp6svqiRl #AMR

[Infectopeds @Infectopeds]

A trial published found that a 4-month regimen for nonsevere, drug-susceptible TB in children is as effective as the standard 6-month. @ABsteward @BradSpellberg #Pediatrics #InfectiousDiseases #TB #InfectoPeds *SHINE. N Engl J Med 2022;386:911-922* https://t.co/1hQSVgvaGm

[Infectopeds @Infectopeds]

@MalcolmMiller6 @ABsteward @BradSpellberg the article is free, but the link is in the post (adobe)

[Infectopeds @Infectopeds]

Our recent study, highlights the significant barriers to accessing novel reserve antibiotics in LMICs.
These antibiotics, critical in fighting MDR infections. The study also offers a six-step pathway to improve access.
@ABsteward @BradSpellberg
https://t.co/Mt6d2kSCSC

[Infectopeds @Infectopeds]

New our paper about Fusarium in braziliam children
#fusarium #pediatric #latam

https://t.co/XSzGmDbn8e

[Infectopeds @Infectopeds]

@surf4children @LaelYonker 👏👏