Irenaeus Chan

[Kelly Bolton MD PhD @KellyLBolton]

Chemotherapy and ionizing radiation are known to promote clonal hematopoiesis and its progression to leukemia. By inducing temporary quiescence of hematopoietic stem cells during external stress might we mitigate CH expansion? We address this through a collaboration with @AbdelWahablab @PuZhang09980432: https://t.co/DUExKVNRSg. Excited to share this and some thoughts from a recent meeting in Hiroshima which puts this work in a broader perspective.

[Abdel-Wahab Lab @AbdelWahablab]

We are now excited to move this forward in prospective trials. Thanks to Neil Hirsch Foundation,
@break_cancer, @ASH_hematology, @BloodCancerUtd, @nih_nhlbi, @theNCI, @TheVFoundation, & Edward P. Evans MDS Foundation.

[Abdel-Wahab Lab @AbdelWahablab]

Similarly, in a mouse model of TP53 mutant clonal hematopoiesis, we found that contemporaneous administration of a CDK4/6 inhibitor with platinum chemotherapy mitigated p53 mutant cell expansion with chemotherapy:

[Abdel-Wahab Lab @AbdelWahablab]

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432

https://t.co/PkB6FViUCk

[Nancy Gillis 🆖☮️ @nancykgillis]

Summary of our @NatureGenet article by the outstanding first author @S_Marzban. Take a 👀:

[DrawImpacts @DrawImpacts]

We had such a blast designing the slides for Irenaeus Chan’s plenary talk from @KellyLBolton’s lab at #ASH25 !
Big congratulations to both of them on this impactful work: "CDK4/6 Inhibition Mitigates Chemotherapy-induced Expansion of TP53-mutant Clonal Hematopoiesis.” #DrawImpacts

[calliecoombs @calliecoombsmd]

Wow this is beautiful work @KellyLBolton looking at CDK4/6 inhibitors as CHIP-protection in solid tumor pts getting chemo! #ASH25

[Vijay Sankaran @bloodgenes]

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @KellyLBolton lab! #ASH25

[Moffitt Cancer Center @MoffittNews]

Happening now at the #ASH25 Plenary: Irenaeus Chan from the @KellyLBolton lab shares new data showing that pharmacologically induced quiescence of hematopoietic stem cells may be a promising strategy to reduce therapy-related myeloid neoplasm risk.

Conclusions:

• Across multiple randomized placebo-controlled double-blind trials, trilaciclib reduced chemotherapy-induced DNA damage associated clonal hematopoiesis.

• In a murine model, CDK4/6 inhibitors prior to carboplatin suppressed chemotherapy-induced Trp53-mutant clonal expansion.

• CDK4/6 inhibition protects Trp53-WT hematopoietic stem cells while potentially promoting apoptosis in Trp53-mutant clones.

#MoffittASH25 @ASH_hematology @SitemanCenter @washumedicine

[Joshua Zeidner MD @LeukDocJZ]

Outstanding Plenary talk @ASH_hematology by Chan from @KellyLBolton lab showing mechanistically how CDK4/6 inhibition can abrogate chemo-induced expansion of TP53-m and DNA-damage associated clones. Such a cool & impactful story 👏👏👏

[Yazan Madanat, MD @madanatyazan]

Huge congratulations 🎉🎊 to @KellyLBolton and her lab @WashU for an outstanding #ASH25 Plenary presentation on reducing therapy-related myeloid neoplasms. TP53 + MN remain one of our greatest challenges, #prevention is key. #Awesome work! #ASH25 @AbdelWahablab @MSKCancerCenter

[Dr. Uma Borate: Associate Professor @beatalleukemia]

#ASHkudos to plenary from @KellyLBolton lab & collaborated @AbdelWahablab tackling THE most important clinical issue for our patients- potential prevention of t-MN by suppressing TP53 clonal expansion. A topic close to my heart. Onwards ! #ASH25

[Christopher Graham @ChrisGrahamMD]

Great plenary session from Irenaeus Chan of the Bolton lab who presented their findings of trilaciclib, a CDK4/6 inhibitor, and its impact on reducing TP53 mutated hematopoeisis following chemotherapy. #ASH25 @ASH_hematology @KellyLBolton

[Taha A, MD, MBA @Taha_CancerDoc]

Very intriguing results indeed, CDK4/6 inhibitors might be our path to prevent secondary myeloid neoplasms following cytotoxic drugs , congratulations to the research team on this amazing work @KellyLBolton #ASH25

[Dr. Uma Borate: Associate Professor @beatalleukemia]

#ASH25 bidding farewell to the amazing community & science that is @ASH_hematology . #ASHkudos to everyone who worked behind the scenes to make magic happen- see y’all at #ASH26 . Pic of 2 plenary duos-introducer & presenter

[Grant Challen @challenlab]

Irenaeus Chan representing the @WashUCancerBio program with style in the plenary session of #ASH25 !!