MDMA plus high-dose psilocybin was the hardest psychological work Andrew Huberman has ever done.
He is explicit: no one should try this without clinical support, and many people should not take these compounds at all. He has only done the combination twice.
MDMA first created the empathogen effect that made difficult material approachable. Psilocybin alone at four to five grams of dried mushrooms had been terrifying and physically harsh.
Together, the MDMA allowed him to stay with the hardest childhood material instead of pushing it away. He also reported no typical post-MDMA drop.
Both compounds increase neuroplasticity in different ways, MDMA primarily through elevated serotonin and oxytocin systems, psilocybin through 5-HT2A receptor activation, which may explain why the sequence felt uniquely intense and why the usual comedown was absent.
Huberman has a rare ability to describe extreme personal experiences with precision, honesty, and strong caveats. That combination is what makes his accounts trustworthy.
Some features:
• Triggers (crons, webhooks), memory, shared files
• Connectors for a company brain
• Agent browser support
• Shareable web app artifacts
• Multi-player projects
Like many things we do at YC, it’s an experiment. It’s early and has bugs. But it’s been surprisingly useful for us so far, and we’re excited to share it and get feedback from the community.
If you want to host it yourself, try telling your coding agent of choice to “deploy https://t.co/yKmDDWRIcX”
מי כעמך ישראל!
Hundreds of dollars were donated by complete strangers to a family in need based on 1 tweet.
Others offered to help in various ways.
The family was moved to tears. I am too.
Thank you
This is a cry for help
The wife of my childhood friend sent me this message, which destroys my heart to have to post. If you are able to help this family, or know someone who can please DM me.
Ps they live out of town. I contacted tomchei shabbos who said they cannot help
Thank you to everyone who gave. Additional funds will be used to help them pay for the yomim tovim.
If you are in a position to help further or k ow someone who is pls contact me privately
The same reason gedolim biographies are all copy paste - the community is trained that only certain compliments/accomplishments are allowed/meaningful. Anything outside of that is a threat.
The problem becomes it renders those things generic and thus meaningless
Why are ultra-Orthodox eulogies so bad?
It’s something I think about almost every time I’m at a funeral. The dearth of native English speakers definitely doesn’t help.