Isabel Mayayo-Peralta

PhD student in the Zwart lab | NKI | 👩‍🔬🧬🔬 Studying hormone-dependent cancers

[Isabel Mayayo-Peralta @IsabelMayayo]

🧬1/ How do SHRs regulate transcriptional activity, and which components of the SHR-coregulator complex are essential for transcription? Our study, published in @NAR_Open, used a FACS-based CRISPR screen to dissect the GR complex. https://t.co/vR3wOXfh76 🧵

[bioRxiv @biorxivpreprint]

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator https://t.co/GYNJ8qoAA0 #bioRxiv

[Isabel Mayayo-Peralta @IsabelMayayo]

@ipaniaguac @NAR_Open Thank you @ipaniaguac !! ☺️☺️☺️

[Isabel Mayayo-Peralta @IsabelMayayo]

🧬1/ How do SHRs regulate transcriptional activity, and which components of the SHR-coregulator complex are essential for transcription? Our study, published in @NAR_Open, used a FACS-based CRISPR screen to dissect the GR complex. https://t.co/vR3wOXfh76 🧵

[Isabel Mayayo-Peralta @IsabelMayayo]

@damirvareslija @Stefan_Prekovic @NAR_Open Thank you @damirvareslija !! ☺️☺️

[Isabel Mayayo-Peralta @IsabelMayayo]

@RSiersbaek @zwartlab @NAR_Open @biorxivpreprint @NKI_nl @oncodeinstitute Thank you @RSiersbaek !! 😊😊

[Isabel Mayayo-Peralta @IsabelMayayo]

8/ A huge thank to my amazing promoter @zwartlab and co-promoter @Stefan_Prekovic for their invaluable guidance! Gratitude also goes to our fantastic collaborators @AHoutsmuller, @AltelaarM, and @NKI_nl and @oncodeinstitute, for their support in this research! #PAXIP1 #STAG2

[Isabel Mayayo-Peralta @IsabelMayayo]

7/GR & PAXIP1 bind the genome, inducing enhancer-promoter interactions. PAXIP1KO reduces cohesin binding to GR-sites, impairing transcription. PAXIP1KO may disrupt insulator loops & thereby increase gene expression. A fascinating interplay between PAXIP1, STAG2 & GR!

[Isabel Mayayo-Peralta @IsabelMayayo]

@AmitK_Dash @zwartlab Thanks! In a parallel study, van Schie JMM et al. looked at the role of PAXIP1 in mitosis, showing also to be important for cohesin function throughout the cell cycle. here the pre-print: https://t.co/5ynBgD68zu

[Isabel Mayayo-Peralta @IsabelMayayo]

@MichalLaurent11 @Stefan_Prekovic Thanks @MichalLaurent11 !!

[Stefan Prekovic @Stefan_Prekovic]

Check out our new preprint - https://t.co/12dDJEpOFo. Anyone interested in co-regulators of transcription factors should definitely take a look. This work was led by our fantastic PhD student @IsabelMayayo

[Isabel Mayayo-Peralta @IsabelMayayo]

@z_pogacar @Stefan_Prekovic @zwartlab Thanks @z_pogacar !

[Isabel Mayayo-Peralta @IsabelMayayo]

@anthonymuler Thanks @anthonymuler !!

[Isabel Mayayo-Peralta @IsabelMayayo]

@AnnaGManjon @HFSP @TheCesareLab Congrats Anna!! 👏🏼👏🏼👏🏼

[Isabel Mayayo-Peralta @IsabelMayayo]

@AnnaGManjon @zwartlab @Stefan_Prekovic Thank you Anna ☺️☺️☺️

[Isabel Mayayo-Peralta @IsabelMayayo]

Really happy to share our latest work! @zwartlab @Stefan_Prekovic Check this out if you would like to know more about CDK4/6 inhibition in breast cancer! Thanks to all the collaborators for their fantastic contribution to this work ! https://t.co/1QdSzEQOxl

[Isabel Mayayo-Peralta @IsabelMayayo]

@Suz_Stelloo @LabVermeulen @NWO_Science Amazing news!! Congratulations @Suz_Stelloo !! 🎉🎉🎉