The Cesare Lab

We study the mechanisms that maintain genome integrity in human cells.

This account is no longer used.

Find us on Blue Sky: @thecesarelab.bsky.social

[The Cesare Lab @TheCesareLab]

Hello friends - we are now on Blue Sky:

@thecesarelab.bsky.social

We will continue to post here for the immediate future but expect a complete migration to Blue Sky in coming months.

Please do reach out and connect with us there.

[The Cesare Lab @TheCesareLab]

26/Finally, the data are consistent with t-loops suppressing ATM activation by the chromosome end.

We show for the first time that t-loops are opened in a shelterin-dependent manner to signal cellular stress, suggestive of a broader role for these structures in cell biology.

[The Cesare Lab @TheCesareLab]

1/Today in @NatureComms

“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.

Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.

https://t.co/VypPsLBJCR.

[The Cesare Lab @TheCesareLab]

25/We predict this represents non-canonical telomere-dependent tumour suppression activity outside the canonical ageing-dependent proliferative barriers imposed by telomere erosion.

Also, we now know the protective functions of the TRF2 basic domain are mitosis specific.