Isabel Wassing

DPhil in Molecular Cell Biology in Health and Disease (University of Oxford), Postdoc at the Rockefeller University

[Hironori Funabiki @HironoriFunabi1]

Here is the link to a news letter article covering our finding.
https://t.co/zX16tN2cii

[Hironori Funabiki @HironoriFunabi1]

Excited to share the revised version with a new title "CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes"
now published @ScienceAdvances!

Congrats @IsabelWassing, @QingyuanJia, @NishiyamaAtsuya, @KyoheiArita!

https://t.co/UQ8b0SWzwT

[Yasuhiro Arimura @ArmrYshr]

Please repost!
Arimura Lab is hiring! We are seeking the next generation of MagICians (technicians and a postdoc) to elucidate the structural basis of events on chromosomes🧙‍♀️
No prior structural biology experience is required!!

Link
https://t.co/QVLcmBzefx

[Yasuhiro Arimura @ArmrYshr]

Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events!

BioRxiv: https://t.co/Onqt0vj3J0

[Isabel Wassing @IsabelWassing]

We’re excited to investigate the ways in which the recognition of hemi-methylated CpG by CDCA7 may differ from its recognition by UHRF1. Currently having fun thinking about the potential roles of a hemi-methylation sensor… better get back to the bench! @HironoriFunabi1 7/7

[Isabel Wassing @IsabelWassing]

Very excited to announce our pre-print! Together with the labs of @NishiyamaAtsuya and @KyoheiArita, we’ve discovered that the protein CDCA7 (a long-time favourite in the Funabiki lab) exhibits a striking ability to sense hemi-methylated DNA. 1/7
https://t.co/Eu0EBCOibH

[Isabel Wassing @IsabelWassing]

…saw the specific accumulation of CDCA7 on hemi-methylated DNA, which also recruits HELLS. Suddenly, the unique role of the CDCA7-HELLS nucleosome remodeler in DNA methylation starts to make more sense. As always, several intriguing questions remain. 6/7