IslaySmoke

I watch the UFC and say, "I could beat that guy" after every fight.

[IslaySmoke @IslaySmoke]

@dickmasterson “Why have cameras at the border? We can see the illegals with our eyes.” When it comes to using AI, surveillance, and state muscle to impose law & order, you have zero creativity. You can only imagine leftists doing it and imply the tools are inherently evil. Dead-end doomerism.

[IslaySmoke @IslaySmoke]

@dickmasterson So, surveillance has no effect on behavior? And all security footage isn’t evidence? Your black-pilling 2013 4chan mentality is stale. “The system will never allow prosecutions, bro.” And if the feds are sent in to clean up cities, it’s “useless” or “fascism.” Update your priors.

[IslaySmoke @IslaySmoke]

@FracSlap @dickmasterson And this is true across Texas cities, esp. Houston, Austin, SA, and Dallas. All have DAs offices that have essentially legalized vagrancy, public drug use, car break-ins, etc., so the encroachment into public spaces expands and the law-abiding are prey. Cameras are the last hope.

[IslaySmoke @IslaySmoke]

In previously safe suburban parks, junkies smoke fent in the bathroom and lounge around strung out, shouting at families. This happens in broad daylight. Soft-on-crime DA won’t prosecute and police are underfunded and defanged. In the absence of any enforcement, cameras would be welcome. The *status quo* is a de facto “police state” run by schizo bums.

[IslaySmoke @IslaySmoke]

@smcroasters If you have a baby trying to sleep and some drunken scumbag is firing off a shotgun, repeatedly, it’s a problem. That’s what fireworks sound like. But thanks for the redneck clickbait.

[IslaySmoke @IslaySmoke]

When you have babies, it becomes clear why fireworks should be a death-penalty eligible crime.

[IslaySmoke @IslaySmoke]

You lose every argument because you’re incoherent.

GLP-1s help people lose weight and show promise to fighting other addictions like alcohol and tobacco. If it’s a vast conspiracy to keep us sick, why would so many pharma companies be making them (and improving them)?

Wouldn’t they hide the inventions?

No, they sell them and make billions because drugs that work are popular.

Shallow opportunists who hustle people looking for magic cures can’t reconcile how Evil Big Pharma invented the best peptides, so instead they whine about the prices to keep their phony morality play afloat.

If these ROUs were so effective, wouldn’t they follow the GLP-1 playbook and profit massively?

You can’t pick a lane and then rage quit. The audience can see what you’re all about and what you’re selling with your yellow pages list.

[IslaySmoke @IslaySmoke]

You should ask your AI LLM to find the blockbuster peptides in the drug pipelines right now.

The vast majority are metabolic & obesity peptides, proving my point. The handful of others are also highly-engineered and, yes, made by biotech/pharma firms. Again, proving my point. None of the current en vogue ROUs, whether BPC or Epitalon, etc., are on that list.

You seem to think the lack of human trials means they *could* be effective, as if a lack of evidence isn't dispositive. You don't seem to grasp that if in vitro/rodent studies showed any potential, those human trials would happen. And in the case of BPC, they were a bust.

But no, no, it's a vast conspiracy to make everyone sick. Not a single biotech company, anywhere in the world, is exempted from this effort to keep us in chronic pain and hide these magic elixers. Even the *guaranteed profits* from these cures aren't enough because these monsters are just that evil!

[IslaySmoke @IslaySmoke]

Yes, and those original GLPs were all FDA-approved and heavily-engineered to last longer than a few minutes (unlike the peptide placebos that rubes like you are injecting).

Exenatide, liraglutide, and dulaglutide were all Big Pharma creations. They required sequence modification, lipidation, or fc-fusion to overcome the body's ability to nearly instantly metabolize them.

BPC-157 has none of these engineering necessities. You cannot explain BPC-157's mechanism of action, which receptors it interacts with, how it can have a systemic effect with a half-life that lasts minutes, or a single human trial that showed any efficacy or safety.

But yeah, bro, body-builders, bro, they nailed it again, bro, chef's kiss, bro.

Yeesh.

[IslaySmoke @IslaySmoke]

Lilly puts 20% of revenue back into R&D, and another 12% into CapEx (factories to make the medicine).

That’s how new blockbuster drugs are developed.

Are you saying that any American making less than $50K should get free GLPs from Lilly, as mandated by the federal government?

Even in the UK, NHS usually doesn’t cover Zepbound and people pay U.S. prices.

And again, Lilly’s margins (~80%) are still much lower than those gray market thieves (500-1,000%) who extol their own necessity/heroism in the name “access.”

If you truly believe in this so deeply, you can buy the powder from China and give it away at cost. Clearly, you have the connections, as shown by your website, and don’t believe you’d be violating any laws.

[IslaySmoke @IslaySmoke]

Nobody will die immediately from a lack of a GLP. They *will* die if they have cancer and can’t get Keytruda.

Keytruda costs $150,000+ per year without insurance, so at least 500x more than a $300 monthly Zepbound Rx.

Should Merck be forced to give Keytrudaaway for free because otherwise, people will die?

Is your argument that “If someone needs the med, pharma shouldn’t be able to charge a market price?” And therefore theft by China is permissible?

Or do you want full-blown Chavista socialism where any effective drug privately developed and financed by pharma becomes a public good?

[IslaySmoke @IslaySmoke]

@PeptideProSrc @PeptideList Lilly spent between $1.0-2.5 billion developing Tirzepatide. Their operating margin on TrumpRX pricing for Tirz is ~50% which is orders of magnitude lower than the gray market resellers (thieves) charging 5-10x (500-1,000%) their wholesale cost for Chinese pirated powder.

[IslaySmoke @IslaySmoke]

Respectfully, you're not addressing any of my points.

Your view might be clouded by the fact that your website is essentially a "yellow pages" for the very shops I'm talking about: domestic resllers who import Chinese powder (stolen Lilly/Novo IP) and mark it up 5-10x for their own cut.

So, their rampant profiteering is OK, as long as the net price is lower than Lilly's? Allowing Chinese pirates to steal American inventions and export unregulated powders is permissible because people "can't" pay $200 a month?

Again, if you want reforms, Medicaid can expand coverage. And yes, even those below the poverty line typically have money for carnal vices (tobacco, drugs, booze, gambling, etc.). $200 per month isn't insurmountable.

The next Keytruda requires pharma to earn a profit to fund the research and trials. It's easy to bash "m'uh Big Pharma" (who, while imperfect, actually save lives) while venerating the fly-by-night thieves who steal their inventions.

But ultimately, you're arguing, "We need socialized medicine and all pharma drugs should basically be nearly free, otherwise we can steal them."

And then when the drug pipeline goes bare, then who's to blame?

[IslaySmoke @IslaySmoke]

@alexaaronlab You post affiliate links for a peptide vendor reselling Chinese powder (stolen Lilly IP) at a 5-10x markup. $100 for 10mg of reta? Likely imported for $1-2 per mg from the Chinese labs. If it’s all about “civilian protection” & “access,” why charge so much?

Spare us your piety.

[IslaySmoke @IslaySmoke]

But you highlight a paradox of the gray market pimps:

(1) "It's just a handful of people buying Chinese powder, Lilly isn't losing much revenue, this isn't a big deal, calm down, bro."

(2) "But also, millions can't afford GLP-1s (even with a discount or insurance), and so they have a right to steal Lilly's IP via gray market imports from Chinese thieves."

Which is it?

Is there any limit to scale of gray market where it becomes problemic? Is the ultimate argument a that Lilly must drop prices by 90%, or else large-scale theft by China is permissible?

So, Lilly has no right to recoup the billions they invested in R&D and clinical trials and then profit from their novel invention so they can invest in future blockbuster drugs?

The federal government and states, via price negotiation and coverage decisions, can increase access via Medicaid for those below the poverty line.

Unpopular to say, but many of those claiming they can't afford $200/month for "life-saving" GLPs probably have a budget for weed, alcohol, gambling, porn, and other wasteful vices.

Additionally, GLP-1s aren't "life-saving" in the acute way that Keytruda is. Obesity is a co-morbidity, but it's not pancreatic cancer. Keytruda can cost >$150,000 per year without insurance. Should it be free?

Again, if the domestic resellers cared so much about "access," they wouldn't be charging 5-10x markups for the powder they import. This isn't a moral mission for them. They're no different than guys selling fake Rolex watches and Gucci bags on Canal Street in NYC.

The resellers are cashing as quickly as possible before the doors shuts. They're the endpoint dealers for Chinese bandits. They don't care about anybody but themselves.

[IslaySmoke @IslaySmoke]

But the resellers (e.g., “Apex Alpha Peptide Bro, Inc.”) are simply relabeling Chinese lyophilized powder, not obtaining it from domestic compounding pharmacies.

There’s no “life-saving” need for retatrutide versus Zepbound or Ozempic. If states or the feds want to negotiate discounts (like via TrumpRX), they can, or offer more robust coverage via Medicare and Medicaid.

Resellers hide behind a bogus “Robin Hood” ethics of excusing or celebrating their theft by saying, “It increases access.”

If that’s the case, why are they all taking their cut? Many of them mark up the price 5-10x per vial after importing it. They’re not running a charity.

The sins of Pharma don’t excuse the craven piracy of the gray market, or the reckless “longevity/wellness” doctors encouraging naive patients to inject peptides with scant/no human clinical trial data for efficacy or safety.

[IslaySmoke @IslaySmoke]

Yes!

Peptide resellers think "research only" is a magical shield against their participation in industrial-scale theft by China, flagrantly violating state and federal laws. But it's meaningless, esp. when they're instructing buyers on how to reconstitute and inject the imported, stolen IP they're hawking.

It'd be like running a streaming site with pirated movies from Russian torrents and saying, "I'm immune because I said it was for 'educational purposes only!"

When the crackdown happens, do they think FDA, FTC, DOJ, or state's Attorney General will care about their irrelevant disclaimers? Or the medical licensing boards won't sanction doctors pushing patients to inject Category 2 peptides that can't even be legally compounded in the U.S?

When Lilly, Novo, and other IP holders sue them civilly, do they think the courts will rules that it's OK to steal their inventions because the vials said ROU? Totally delusional.

Similarly, the "not medical advise" disclaimer is meaningless. It's *always* followed by medical advice, like clockwork. The clickbait doctors (mostly chiropractors, not real MDs) who engage in that practice have immense liability.

It's a swamp and the arrogance and false piety of the ringleaders is exhausting.