Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. @Dev_journal
https://t.co/Mo0iGIrZIZ
How do cells decode #TF oscillations and how does this impact development? We find #NGN3 protein oscillates in #pancreatic endocrine cells, #oscillations are likely decoded via fold-change and impact on the timing of differentiation, but not fate choice: https://t.co/OYZSa3ryyU
What happens when you give Notch a kick?
Notch is a powerful signalling pathway for generating spatial patterns but often leads to stationarity. Here we describe how to make it dynamic and match tissue data by introducing perturbations to the signalling.
https://t.co/Pd8eFamZLk
@PapalopuluLab Presented a talk with @BigaVeronica today at the @TLM_Cambridge seminar series. Here’s an interactive version of the model that you can play around with!
Cells in tissue are using ‘group chats’ to make decisions!
Multiscale synthesis of fine-grained protein expression of HES5 reveals locally co-ordinated clusters and stripes that control rate of progenitor differentiation.
bioRxiv: https://t.co/n5eLH6bHTq
1/5
"If mathematical modeling is such a nifty tool, why has it taken so long for molecular biologists to incorporate it into their armamentarium?" Excellent, thought-provoking, under-appreciated article from 2015 by Tyson and Novák https://t.co/d2YI7rVM3m