Josh Hawley

Biophysics PhD student in the Papalopulu lab at the University of Manchester.

[Papalopulu Lab @PapalopuluLab]

Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. @Dev_journal
https://t.co/Mo0iGIrZIZ

[Papalopulu Lab @PapalopuluLab]

How do cells decode #TF oscillations and how does this impact development? We find #NGN3 protein oscillates in #pancreatic endocrine cells, #oscillations are likely decoded via fold-change and impact on the timing of differentiation, but not fate choice: https://t.co/OYZSa3ryyU

[Josh Hawley @ItsJoshSurely]

What happens when you give Notch a kick?

Notch is a powerful signalling pathway for generating spatial patterns but often leads to stationarity. Here we describe how to make it dynamic and match tissue data by introducing perturbations to the signalling.

https://t.co/Pd8eFamZLk

[Josh Hawley @ItsJoshSurely]

@PapalopuluLab Presented a talk with @BigaVeronica today at the @TLM_Cambridge seminar series. Here’s an interactive version of the model that you can play around with!

[Papalopulu Lab @PapalopuluLab]

Are you interested in lateral inhibition patterns emerging in #motilecells with #dynamic #protrusions ? Check out this #interactive multicellular neural tissue simulation tool made by @ItsJoshSurely https://t.co/GK6h5r8lCW

[Papalopulu Lab @PapalopuluLab]

Cells in tissue are using ‘group chats’ to make decisions!

Multiscale synthesis of fine-grained protein expression of HES5 reveals locally co-ordinated clusters and stripes that control rate of progenitor differentiation.

bioRxiv: https://t.co/n5eLH6bHTq

1/5

[Josh Hawley @ItsJoshSurely]

@padabecky @RecoverChloe @mattyfox350 @Luke__McDonnell @ItsRachForShort I recall lasting about 4 days and then going home.

[Steven Strogatz @stevenstrogatz]

"If mathematical modeling is such a nifty tool, why has it taken so long for molecular biologists to incorporate it into their armamentarium?" Excellent, thought-provoking, under-appreciated article from 2015 by Tyson and Novák https://t.co/d2YI7rVM3m

[Josh Hawley @ItsJoshSurely]

@Andyrowntree Wooh!

[Veronica Biga @BigaVeronica]

Well done to Josh @SulphuricCheese @PapalopuluLab for winning the #plm14 poster prize! Big thank you to the organisers @TLM_Cambridge

[Josh Hawley @ItsJoshSurely]

@perkins_connor I have indeed, are we gonna have to go?

[Josh Hawley @ItsJoshSurely]

@perkins_connor I have indeedy :P watching the last episode of series 1 tonight D: :O :D *head explodes in excitement*

[Josh Hawley @ItsJoshSurely]

@perkins_connor finally watching it :D

[Andy @andybrinners]

Passenger is pure brilliance

[Josh Hawley @ItsJoshSurely]

@ColouringItIn please, you don't have the guts to eat my sandwich 2 days in a row...

[Josh Hawley @ItsJoshSurely]

@ColouringItIn not true.