Ivan Ahel Lab

[Ivan Ahel Lab @IvanAhelLab]

The first chemical synthesis of ADP-ribosylated oligonucleotides provides powerful tools to study ADP-ribosylation of nucleic acids
https://t.co/7A3ohO6AXf

[Ivan Ahel Lab @IvanAhelLab]

Learn more about the interplay between ADP-ribosylation and ubiquitination: PARG regulates proteasomal degradation of the ADP-ribosyl hydrolase TARG1 by preventing PAR-dependent ubiquitination mediated by the E3 ligases HUWE1 and TRIP12
https://t.co/uG18YrbpSM

[Ivan Ahel Lab @IvanAhelLab]

The interplay between ADP-ribosylation and ubiquitination, mediated by PARP7 and DTX2 proteins, can serve as a rapid AHR transcription “off-switch” through proteasomal degradation.
https://t.co/zQvgD2rAT2

[Ivan Ahel Lab @IvanAhelLab]

Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells.
https://t.co/6tle1I0XeG

[Ivan Ahel Lab @IvanAhelLab]

Here you can read our full review paper on the interplay between ADP-ribosylation and ubiquitination, with special focus on dual, hybrid modification ADPr-Ub:
https://t.co/NwBX6caZvX

[Ivan Ahel Lab @IvanAhelLab]

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
https://t.co/YyYXYDHRyr

[Ivan Ahel Lab @IvanAhelLab]

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
https://t.co/gZ1DgWp31d

[Ivan Ahel Lab @IvanAhelLab]

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
https://t.co/zNqo4KsI4Z

[YuGeng Zhang @YugengZ]

Really thrilled to see our paper out now in @NAR_Open: a new transcriptional repressor, RptR, that regulates type I restriction-modification systems! 🎉

Big thanks to @TangLabOxford, @_MarionSchuller, @IvanAhelLab, and @BlowerLab!

https://t.co/KArzPouXSf

[Ivan Ahel Lab @IvanAhelLab]

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.

https://t.co/Mnxh1NutMw

[Ivan Ahel Lab @IvanAhelLab]

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort)
https://t.co/iWjymR9A7i

[Ivan Ahel Lab @IvanAhelLab]

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
https://t.co/2LTFVQTqIb

[Rahul Samant @SamantLab]

Call me a #ubiquitin geek, but this is genuinely one of the most exciting findings in recent years. Only came across Ub—ADPr a few years back with some pioneering @IvanAhelLab papers. New field emerging here, folks!

[Ivan Ahel Lab @IvanAhelLab]

Our discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence protein module against toxic attack

https://t.co/NpdMx1RP4H

[Ivan Ahel Lab @IvanAhelLab]

Potential PhD students interested to work in our laboratory are welcome to apply through the ILESLA programme

[OxfordEnvRes @OxfordEnvRes]

Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to their website https://t.co/m5ojMz7tek where you can see open day videos and guidance

[ConstantinouLab @ConstantinouL]

We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK

[Ivan Ahel Lab @IvanAhelLab]

Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.

[Ivan Ahel Lab @IvanAhelLab]

Our new paper in collaboration with Luca Palazzo laboratory:
https://t.co/BnCS7OKpA7

[Luca Palazzo @PalazzoLuca]

Our findings indicate that this synthetic lethal interaction is notably strengthened when paired with alkylating genotoxins. (3)

[Antonio Ariza @DrAntonioAriza]

We're in the news. 😊
@JgmRack @IvanAhelLab @LeidenADPr @physorg_com
https://t.co/8TDB7JKVPC
https://t.co/WvrFj2ChjX

[Marcin J. Suskiewicz @MSuskiewicz]

Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: https://t.co/CM3poCelab