Ivan Lee

Physician-scientist in Allergy/Immunology | Pediatrician. Views are my own.

[Sizun Jiang @SizunJ]

So great to see this out online today @ImmunityCP

Such an honor to work with a fantastic team of brilliant minds and generous mentors in developing methods and ideas to understand host-viral interactions in their native context. Looking forward to more!
https://t.co/IngKSjJBdE

[Sizun Jiang @SizunJ]

Single-cell matching using BOTH shared and distinct features now possible with MARIO, an incredible effort by Bokai Zhu and @ShuxiaoC, together with Zongming Ma and @GarryPNolan. Align single cells across modalities (eg CyTOF, CODEX, CITE-seq) or species https://t.co/W4kl0NRtU2

[The Triological Society @Triological]

Check out this #RCT examining effects of povidone‐iodine (PVP-I) nasal sprays on #COVID19 nasopharyngeal viral load! Authors found PVP-I did not demonstrate virucidal activity in COVID19 positive outpatients @StanfordOHNS @CincyENT @UCRhinology https://t.co/vm0dfUCoL9

[Ivan Lee @IvanLeeMDPhD]

A nicely written summary by @kristac of our recent work highlighting SARS-CoV-2 tropism for the human nasal cavity and an association between smoking and susceptibility to #SARSCoV2

[Stanford Medicine @StanfordMed]

When they compared the levels of virus in the respiratory tissues in nonsmokers to those of smokers, the researchers found something interesting. https://t.co/V4nkoNPjgt
#Smoking #COVID19

[Eric Topol @EricTopol]

The nose and the trachea are the sites where #SARSCoV2 preferentially replicates, have the highest expression of the 2 key entry factors (ACE2 and TMPRSS2), as determined by extensive single-cell RNA-sequencing
https://t.co/WzKRfnRYYA

[Jeff Gilchrist @jeffgilchrist]

COVID-19: Where the virus replicates most and impact from smoking

A study analyzed various human mucosal tissues of the head and neck and compared the amount of COVID-19 entry factors such as ACE2 and TMPRSS2 in each ( https://t.co/XA9SzPSLNV ). 🧵1/

[Ivan Lee @IvanLeeMDPhD]

@jeffgilchrist Thank you for highlighting our work!

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan @ACDbio We also show a rare image of #SARSCoV2 infection in human olfactory tissue. This was made possible through the hands of the talented rhinologist @DrYanENT (extremely difficult to sample intact human olfactory tissue). #anosmia is a common & often lasting symptom of COVID-19

[Ivan Lee @IvanLeeMDPhD]

Happy to share our latest human translational #COVID19 work. This work was co-led by @HisaNakayama, @SizunJ, @DrYanENT, Drs. Matter, Overdevest, @WCT_Cilia, Goltsev, and me. It's another original from @GarryPNolan, Drs. Jayakar Nayak & Alex Tzankov. https://t.co/h19P7pV4kr

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan @ACDbio To show the causative effects of smoking on IFNB1 expression, @WCT_Cilia from the Jackson lab and Drs. Lidsky & Xiao from the Andino lab exposed CS to cultured human nasal epithelial cells b4 infection w/ SARS-CoV-2.. 🚬 exposure ⬆️⬆️⬆️ the number of infected cells!!

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan @ACDbio What’s going on? We first looked at the level of SARS-CoV-2 entry factors in airway tissues of smokers; higher levels of entry factors may facilitate SARS-CoV-2 infection. We found no differences in ACE2 and TMPRSS2 in smokers vs non-smokers.

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan Using in situ hybridization @ACDbio combined with immunofluorescent IHC staining, we discover that SARS-CoV-2 has a strong preference to replicate in the nasal cavity & trachea. In layperson terms, #MaskUp over the nose when indoors =)

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan This led us to hypothesize that SARS-CoV-2 preferentially infects the nasal cavity & trachea. To test this hypothesis, we evaluated SARS-CoV-2-infected human proximal airway (nasal cavity, tongue, pharynx, larynx & trachea) tissues collected postmortem from individuals with COVID

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @HisaNakayama @DrYanENT @WCT_Cilia @GarryPNolan This knowledge is fundamental to our defense against SARS-CoV-2. #MaskUp properly over the nose & mouth continues to be a highly effective public health measure. Individuals with severe complications from COVID-19 often have the highest SARS-CoV-2 viral load in the airway

[Sizun Jiang @SizunJ]

Hi friends, the Jiang Lab @BIDMChealth is in business with a great view👀🏙️! 🍀 to be supported @harvardmed➕@DanaFarber➕@VirologyHarvard. Job Postings just dropped for 1) RA and 2) Biostats. DMs open for other positions too.
https://t.co/iIRtcoBN5t
https://t.co/obxji1yRKk

[Ivan Lee @IvanLeeMDPhD]

@DrYanENT @HisaNakayama @zarapatel_md @AdamDeCondeMD Honored to have co-authored this work with you, Carol! 🥂

[Sizun Jiang @SizunJ]

Thank you @EricTopol for highlighting this productive collab to better understand COVID & diabetes. Fearless leadership by Chien-Ting from @PeterKJackson lab, with brilliant colleagues Peter & Yinghong (Andino), Ran (Jackson), @IvanLeeMDPhD & Hisa (Nayak/Nolan) #GetVaccinated

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @bidmc @DanaFarber @harvardmed

[Ivan Lee @IvanLeeMDPhD]

@SizunJ @StanfordMed @GarryPNolan @PeterKJackson 🤣🤣🤣

[Ivan Lee @IvanLeeMDPhD]

Thank you @StanfordMed for the nice lay summary of our collaborative work!
@GarryPNolan @PeterKJackson @SizunJ

[Stanford Medicine @StanfordMed]

SARS-CoV-2, the virus that causes COVID-19, likely enters the body via nasal passages and upper airways, study finds. The study also found that common blood pressure medications are unlikely to increase the risk of contracting COVID-19. https://t.co/aquupchxiL