Russ

[Russ @JJDomDad]

I wrote a book about BAT and other hormonal therapies for PCa. It's on amazon. Free if you have kindle unlimited, otherwise amazon made me charge $2.
https://t.co/qZIbD2vhfw

[Russ @JJDomDad]

@bryceolson @SarahE_Richards Olaparib and BRCA2 synergize. Ola inhibits NHEJ repair and BRCA2 reduces the effectiveness of HR repair (DNA DSBs are almost exclusively repaired through NHEJ or HR).

Interesting results for BAT/olaparib. Seems to work regardless of HR mutations. But it was a small trial.

[Russ @JJDomDad]

@SarahE_Richards @bryceolson Olaparib + BAT? Good results in a recent clinical trial.

[Russ @JJDomDad]

@laurasenamd @CR_AACR @Hopkins_HemOnc Would a FAS inhibitor such as orlistat be potentially therapeutic?

[Russ @JJDomDad]

@BatPitt That's too bad that your MO has never heard of BAT. I wonder if they spend much time researching. It is one of the hottest topics in the PCa front. I think pcf said it was #1.

[Russ @JJDomDad]

I wrote a book about BAT and other hormonal therapies for PCa. It's on amazon. Free if you have kindle unlimited, otherwise amazon made me charge $2.
https://t.co/qZIbD2vhfw

[Russ @JJDomDad]

@BatPitt I also had the Dukoral. I don't know if the observational evidence is correlation or causation. But I was in Seattle so a trip across the border was easy. And I figured not much to lose and lots to gain.

[Russ @JJDomDad]

@BatPitt Nice stuff going on.
NCT03554317
NCT04558866
NCT04704505
NCT03522064
NCT05011383
NCT04363164
NCT05081193
NCT02090114
NCT03516812
NCT02286921
NCT01750398
NCT04424654
NCT00586898

[Russ @JJDomDad]

@BatPitt Yup. Propionate is much better IMO.

[Russ @JJDomDad]

@BatPitt Does your MO support it? It is experimental. I took the plunge and so far it seems to have worked well. 15 months and PSA is dropping and PSMA-PET scan is clear.

[Russ @JJDomDad]

@Martin_AngelMD @JimAllisonPhD Hi, is this for PCa? If so, what study is this from and can I see some of the slides?
Thanks, Russ

[Russ @JJDomDad]

@laurasenamd @JRPCFer @HopkinsMedicine @PCF_Science Was it recorded? If so, is there a way for me to view it?

[Russ @JJDomDad]

@laurasenamd Thanks. The BAT/Xtandi trial is one that I am watching closely. I'm using propionate. My MO and I are doing to start Xtandi/BAT/X/B... if I fail BAT.

[Russ @JJDomDad]

@laurasenamd I'm GG5 diagnosed in 2018. Still HSPC.

[Russ @JJDomDad]

@laurasenamd Hi, is this from an RCT? What study or data can I view? Thanks

[Russ @JJDomDad]

@laurasenamd Do you think that ARSIs or nandrolone inhibit MYC?

[Russ @JJDomDad]

@laurasenamd I use propionate instead of cypionate so that I can get down to a true castrate level.

[Russ @JJDomDad]

@laurasenamd Nice graphs! I'm Gleason grade 5, T3c, N1M0 and have been doing BAT for 14 months. My bone density per DEXA has increased 5.20% absolute. My TMB has dropped. My PSA has gone from 0.17 to 0.02. I had a Pylarify PSMA-PET scan a month ago and no signs of cancer were found.